Any other medical or psychological condition that would preclude participation in the study or compromise ability to give informed consent Logistical or psychological hindrance to participation in clinical research Logistical or psychological hindrance to participation in clinical research Chronic or acute renal or hepatic disorder or any other condition, medical or psychological that, in the opinion of the investigator, could jeopardize the subject’s safe participation Physical or psychological condition which would impair study participation; or Any other medical, psychological, or social condition that may interfere with study participation or compliance, or compromise patient safety in the opinion of the investigator Any condition (e.g., known or suspected poor compliance, psychological instability, geographical location, etc) that, in the judgment of the investigator, may affect the patient’s ability to sign the informed consent and comply with study procedures Any other medical, psychological, or social condition that may interfere with study participation or compliance, or compromise patient safety in the opinion of the investigator Any other co-existing medical or psychological condition(s) that will preclude participation in the study or compromise ability to give informed consent and/or comply with study procedures. Patients with psychological or geographic conditions that prevent adequate follow-up or compliance with the study protocol. Any medical or psychological condition that, in the opinion of the investigator, might interfere with the subject’s participation in the trial, poses any additional risk for the subject, or confounds the assessment of the subject Patients with a medical or psychological impediment to probable compliance with the protocol should be excluded DONOR: No psychological traits or psychological or medical conditions which make them unlikely to tolerate the procedure Any other medical, psychological, or social condition that may interfere with study participation or compliance, or compromise patient safety in the opinion of the investigator Any medical or psychological condition or situation deemed by the principal investigator (PI) to put the patient at increased risk of complications or noncompliance Patients with any serious/poorly controlled medical or psychological conditions that would be exacerbated by treatment, would complicate protocol compliance History of alcoholism, drug addiction, or any psychiatric or psychological condition which, in the opinion of the investigator, would impair study compliance Patients with a medical or psychological impediment to probable compliance with the protocol should be excluded DONOR: Serious medical or psychological illness Psychological condition that renders the patient unable to understand the informed consent Psychological or social reasons that would hinder or prevent compliance with the requirements of the protocol or compromise the informed consent process. Psychological or social reasons that would hinder or prevent compliance with the requirements of the protocol or compromise the informed consent process. Patients with psychological or geographic conditions that prevent adequate follow- up or compliance with the study protocol. Any medical or psychological condition that in the opinion of the principal investigator would interfere with safe completion of the trial Any other medical, psychological, or social condition that may interfere with study participation or compliance, or compromise patient safety in the opinion of the investigator or medical monitor Any condition (psychological, physical or use/abuse of substances) which, in the opinion of the principal investigator (PI) or a sub-investigator (sub-I), would possibly endanger the subject during their participation in the study, or allow for non-compliance with the investigational drug and treatment under study Must not have concomitant medical, psychological or social circumstances which would interfere with compliance with the protocol treatment and follow-up Patients with concurrent medical, psychological or social conditions of such severity that the investigator deems it unwise to enter the patient on protocol Unrelated Donor: Serious medical or psychological illness DONOR: Serious medical or psychological illness Any other medical, psychological, or social condition that may interfere with study participation or compliance, or compromise patient safety in the opinion of the investigator The participant has any condition (for example, psychological, geographical, or medical) that does not permit compliance with the study and follow-up procedures or suggests that the participant is, in the investigator's opinion, not an appropriate candidate for the study. Medical, social, or psychological factors that would prevent the patient from receiving or cooperating with the full course of therapy Any other medical, psychological, or social condition that may interfere with study participation or compliance, or compromise patient safety in the opinion of the investigator or medical monitor Social or psychological conditions that the investigator judges may compromise study compliance Medical or psychological impediment to probable compliance with the protocol DONOR: Donors must not have psychological traits or psychological or medical conditions which make them unlikely to tolerate the procedure Uncontrolled concurrent significant medical or psychological co-morbidity Medical, psychological, or social condition that, in the opinion of the investigator, may increase the patient’s risk, interfere with the patient’s participation in the study, or hinder evaluation of study results Patients must not have active uncontrolled infections, other medical or psychological/social conditions that might increase the likelihood of patient adverse effects or poor outcomes Medical, psychological or surgical condition which the investigator feels might compromise study participation Physical or psychological condition which would impair study participation; or Any condition (e.g., known or suspected poor compliance, psychological instability, geographical location, etc) that, in the judgment of the investigator, may affect the patient's ability to sign the informed consent and undergo study procedures. Has medical, social, or psychological factors that, in the opinion of the Investigator, could impact safety or compliance with study procedures Subjects with a medical or psychological impediment to probable compliance with the protocol Any significant psychological, medical, or surgical condition thought to compromise the participant, the study, or prevent informed consent Medical, psychological or surgical condition which the investigator feels might compromise study participation No medical, psychological or surgical condition which the investigator feels might compromise study participation Patients with severe psychological or medical illness History of alcoholism, drug addiction, or any psychiatric or psychological condition which, in the opinion of the Investigator, would impair study compliance Any other medical, psychological, or social condition that may interfere with study participation or compliance, or compromise patient safety in the opinion of the investigator Unstable or severe uncontrolled medical, psychological, or social condition Other medical or psychological conditions that would make participation unsafe or inhibit our ability to test our primary hypothesis, e.g. Parkinson’s disease, severe dementia Major psychological condition that would preclude completion of the intervention Known history of a neurological and/or psychological disorder that in the physician’s opinion may interfere with the patient’s ability to cooperate with study procedures Presence of psychiatric or psychological symptoms which in the judgment of the principal or associate investigators would compromise the donor’s ability to engage in the intervention or is likely to interfere with the study procedures or results History of a neurological or psychological disorder that may interfere with the patient’s ability to cooperate with study procedures Mental incapacitation or significant emotional or psychological disorder that, in the opinion of the investigators, precludes study entry Has a condition or psychological difficulties that affects day-to-day activities Medical or psychological conditions which, in the opinion of the investigator, might create undue risk to the subject or interfere with the subject’s ability to comply with the protocol requirements Any concurrent condition, including psychological and social situations, which, in the opinion of the investigator, would adversely impact the subject or the interpretation of the study data.