Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure (New York Heart Association [NYHA] class II), unstable angina pectoris or myocardial infarction within 6 months of enrolment, serious or life threatening cardiac arrhythmia, subjects with a high probability of long QT syndrome or QTcF prolongation of >= 501 mcsec (grade 2) on at least two separate electrocardiography (ECG) following correction of any electrolyte imbalance or psychiatric illness/social situations that would limit compliance with study requirements
Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, diabetes mellitus requiring therapy (insulin or oral hypoglycemic agents), congenital prolonged QT syndrome, requirement for a drug known to prolong the QT interval, a history of QT prolongation, a screening QTc >= 450 msec, hypertriglyceridemia requiring therapy, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, congenital prolonged QT syndrome, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, congenital prolonged QT syndrome, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
Patients must not have a serious intercurrent illness including, but not limited to:\r\n* Ongoing or active infection requiring parental antibiotics on day 1\r\n* History of congenital long QT syndrome or mean corrected QTc interval > 450 msec at baseline\r\n* Clinically significant cardiovascular disease:\r\n** Myocardial infarction within 6 months\r\n** Unstable angina\r\n** New York Heart Association grade II or greater congestive heart failure\r\n** Serious cardiac arrhythmia requiring medication\r\n* Serious, non-healing wound, active ulcer, or untreated bone fracture\r\n* Psychiatric illness/social situations that would limit compliance with study requirements