The subject has had evidence within 2 years of the start of study treatment of another malignancy which required systemic treatment (with the exception of nonmelanoma skin cancers or carcinoma in situ of the bladder) The subject has had evidence within 2 years of the start of study treatment of another malignancy which required systemic treatment The subject has had evidence within 2 years of the start of study treatment of another malignancy which required systemic treatment; Note: Subjects with a history of early stage or locally advanced non-metastatic prostate cancer within 2 years of the start of study treatment may be included in the study No malignancy (other than the one treated in this study) which required radiotherapy or systemic treatment within the past 5 years Subject has another malignancy for which treatment is required. Concurrent diagnosis of another malignancy if either systemic treatment or surgery is expected to be required within 2 years from study entry Evidence within the last 2 years of another malignancy which required systemic treatment Evidence within 2 years of the start of study treatment of another malignancy which required systemic treatment Subject has a history of a malignancy (other than the disease under treatment in the study) within 5 years before first study treatment administration The subject has had within 2 years before the start of study treatment evidence of another malignancy which required systemic treatment Presence of malignancy (other than the one treated in this study) which required systemic treatment within the past 3 years The subject has had evidence within 2 years of the start of study treatment of another malignancy which required systemic treatment No malignancy (other than for which patient underwent transplant) which required radiotherapy or systemic treatment within the past 5 years The participant has had evidence within 2 years of the start of study treatment of another malignancy which required systemic treatment For disease specific studies: the subject has had evidence within 2 years of the start of study treatment of another malignancy which required systemic treatment For disease specific studies: the subject has had evidence within 2 years of the start of study treatment of another malignancy which required systemic treatment The subject has had evidence within 2 years of the start of study treatment of another malignancy which required systemic treatment