COHORT B, GROUP 2: PANCREATIC CANCER: Patients must have failed a minimum of one previous line of therapy for advanced disease Previous systemic chemotherapy or radiation for pancreatic cancer is not allowed No previous therapy for pancreatic cancer Previous treatment for pancreatic cancer A history of previous chemotherapy for pancreatic cancer or abdominal radiation therapy Patients must have no history of previous chemotherapy for pancreatic cancer or any abdominal radiation therapy No previous therapy for pancreatic cancer Patient must have received no previous radiotherapy, surgical resection, chemotherapy or investigational drug therapy for pancreatic adenocarcinoma Patients who have had previous radiotherapy, surgical resection, chemotherapy or investigational drug therapy for pancreatic adenocarcinoma