Additional criteria may apply. MELANOMA (pembrolizumab only) Additional criteria may apply Other Inclusion Criteria May Apply. Further inclusion criteria apply Other inclusion criteria may apply Additional cohort-specific criteria may apply. Further inclusion criteria apply Subject must be able to provide an evaluable core or excisional biopsy prior to the start of treatment. Other Inclusion Criteria May Apply Other inclusion criteria may apply Other inclusion criteria apply. Other inclusion criteria may apply Further Inclusion criteria apply Further inclusion criteria apply. Further inclusion criteria apply. Additional criteria may apply. Additional criteria may apply. Other exclusions apply Additional criteria apply, please contact the investigator for more information Additional criteria apply, please contact the investigator for more information Additional criteria may apply Additional criteria may apply Other inclusion criteria may apply Other criteria apply. Other criteria apply. Other inclusion criteria may apply Patients unable to apply Estring Other Inclusion Criteria May Apply Criteria 10, Other Inclusion Criteria May Apply. Other Inclusion Criteria May Apply Other criteria may apply, please contact the investigator for additional information Other criteria may apply, please contact the investigator for additional information