Daily smoker using 10 or more cigarettes per day Active smoker NSCLC cohort only: current smoker Is a current smoker Non-smoker Daily smoker for ?6 months Self-reported current smoker Patient is a current or ex-smoker with a smoking history of >= 10 pack years AIM 2: Must be a current or recent former smoker (defined as smoked within past 6 months) AIM 2: Former smoker greater than 6 months Families of all children who have at least one custodial parent smoker Subject is a current smoker, or has smoked within 3 months prior to enrollment, or plans to resume smoking within 3 months post-enrollment As per self-report, is a regular smoker (daily use) Current daily smoker Smoker Current smoker of >= 10 cigarettes per day, on average The subject is a current smoker (has smoked within 4 weeks prior to surgery) INHALATION: Are a smoker Current or ex-smoker with at least 10 pack-year history Currently a smoker, defined as self-reported cigarette smoking (some days, every day) within the past 30 days Current smoker (i.e., at least 10 cigarettes/day) Current smoker (defined as any smoking in the past 30 days – this is the criteria our lung cancer screening programs will use to trigger tobacco treatment interventions) Daily smoker for ? 6 months, smoking approximately ? 5 cigarettes per day on average in the past month or must meet the criteria for nicotine dependence Be either a current smoker or a never smoker; to define a smoker, we will utilize the Centers for Disease Control definitions; any individual who is currently smoking and has smoked more than 100 cigarettes in their lifetime will be identified as a current smoker; smoking status will be assessed by a questionnaire; smoking status will be conferred using a urine cotinine test at the randomization visit (week-2); the number of cigarettes smoked per day and years of smoking will be used to calculate pack-years, which will be used as a measure of tobacco exposure; a never smoker is defined as a person who has never smoked, or has smoked less than 100 cigarettes in their lifetime, and who has not had a cigarette in over ten years Smoker or uses smokeless tobacco products Is a current smoker – self defined Current smoker Current smoker Non-smoker A current or ex-smoker with a >= 10 pack-year history of smoking; (an ex-smoker is defined as no tobacco use in the prior 6 months) Current or ex-smoker with at least a 10-year pack history Current smoker (> 5 cigarettes per day for the past 3 months) Self identified as a smoker Must be a former or current smoker current smoker Non-smoker Current or former smoker by self-report Current smoker of >= 5 cigarettes daily, determined by self-report Current smoker, or former smoker who has less than a 16-year quit history Daily smoker; current smoker of at least 5 cigarettes per day for at least 1 year daily (25+ days within past 30) cigarette smoker of >5 cigs/day