Ongoing sensory or motor neuropathy Grade ?2. No grade >= 2 peripheral motor or sensory neuropathy Neuropathy (sensory and motor) =< CTCAE v 3.0 grade 1 Neuropathy (sensory and motor) less than or equal to CTCAE grade 1 Patients must have < grade 2 neuropathy (sensory/motor) within 7 days prior to registration Subject has preexisting sensory or motor neuropathy Grade ? 2 at baseline Participants with grade >= 3 peripheral motor or sensory neuropathy Neuropathy (sensory and motor) NCI CTCAE grade =< 2 Neuropathy (sensory and motor) less than or equal to CTCAE v4.0, grade 1 Patients who have pre-existing motor or sensory neuropathy of a severity ? grade 1 by CTCAE v4.0 criteria Nervous system disorder (paresthesias, peripheral motor neuropathy, or peripheral sensory neuropathy) ? Grade 2, per the CTCAE v4.0. Grade ? 3 sensory or motor neuropathy. Has not recovered from adverse reactions to prior myeloma treatment or procedures (chemotherapy, immunotherapy, radiation therapy) to NCI CTCAE less than or equal to (<=) Grade 1 or baseline, except for sensory or motor neuropathy which should have recovered to <=Grade 2 or baseline. Sensory or motor neuropathy ? grade 2 Preexisting motor neuropathy Grade ? 2 Neuropathy (sensory and motor) less than or equal to CTCAE v4.03 grade 1 Sensory or motor neuropathy >= grade 2 Ongoing sensory or motor neuropathy Grade 2 or higher. Sensory or motor neuropathy >= Grade 2. Neuropathy (sensory and motor) =< to CTCAE grade 1 Patients with symptomatic peripheral motor or sensory neuropathy >= grade 2 at baseline will receive radiation therapy alone Neuropathy (sensory and motor) less than or equal to grade 1 per Common Toxicity Criteria (CTC) version 4 Grade 3 sensory neuropathy or motor neuropathy with pain Sensory/motor neuropathy >= grade 2 Sensory/motor neuropathy >= grade 2 Patients with any of the following adverse events at the time of enrollment are not eligible:\r\n* Grade ? 2 motor, sensory or peripheral neuropathy\r\n* Grade ? 3 hyponatremia (serum sodium [Na] ? 130 mmol/L) Participant must have either no neuropathy (sensory and motor) or neuropathy less than or equal to grade 1 Patients with persistent grade 2 or higher peripheral sensory or motor neuropathy of any cause Sensory or motor peripheral neuropathy >= grade 2 Sensory or motor neuropathy >= grade 2 Subject has preexisting sensory or motor neuropathy Grade ? 2 at baseline Pre-existing >= grade 2 sensory or motor peripheral neurotoxicity Motor peripheral neuropathy = grade 0 (per CTCAE v. 4.0) Patients must not have a pre-existing > grade 1 motor or sensory neuropathy PHASE II: Patients must not have a pre-existing > grade 1 motor or sensory neuropathy Neuropathy (sensory and motor) =< grade 1 Neuropathy (sensory and motor) less than or equal to CTEP CTCAE version 4.0, grade 1 Pre-existing peripheral motor or sensory neuropathy >= grade 2 Neuropathy (sensory and motor) less than or equal to Grade 1. Preexisting sensory neuropathy Grade ? 2 or motor neuropathy Grade ? 2 Motor neuropathy considered of autoimmune origin Sensory or motor peripheral neuropathy Neuropathy (sensory and motor) less than or equal to grade 1 Neuropathy (sensory and motor) less than or equal to grade 1 Preexisting sensory and/or motor neuropathy Grade ? 2 History of severe motor or sensory neuropathy, or any other autoimmune disorder which is deemed to be significant CTC Grade 1 or greater neuropathy (motor or sensory) from comorbidity other than prior taxane exposure, such as diabetes. Neuropathy (sensory and motor) less than or equal to CTCAE grade 1 Neuropathy(Both motor and sensory) ? Grade1 (CTCAE Version 4.0) Neuropathy (sensory and motor) =< grade 1 according to Common Toxicity Criteria for Adverse Events version 3 (CTCAE) Neuropathy (sensory and motor) less than or equal to grade 1 Neuropathy (sensory and motor) less than or equal to CTCAE v 4.0 grade 1 Patients with pre-existing Grade 2 (or greater) peripheral motor or sensory neurotoxicity per the CTCAE 3.0 as determined by the treating physician or a neurologist. Evidence of baseline sensory or motor neuropathy Neuropathy (sensory and motor) =< CTCAE v4.03 grade 1 Significant peripheral sensory or motor neuropathy at the start of the study. Has sensory or motor neuropathy limiting daily activities. Neurologic function: neuropathy (sensory and motor) ? CTCAE Grade 1 Current/ongoing Neuropathy (sensory or motor) Grade > 1 or any history of Grade ? 3 neuropathy with prior Vincristine or chemotherapy exposure (documentation by history is adequate to exclude) Greater than grade 2 motor neuropathy or greater than grade 3 sensory neuropathy at screening Neuropathy (sensory and motor) less than or equal to CTCAE grade 1 Grade 2 or greater motor or sensory neuropathy Patient does not have a clinically significant neurologic deficit or objective peripheral neuropathy (greater than or equal to grade 2); peripheral (sensory or motor) neuropathy related to limb sparing procedure or amputation is allowed Patients with >= grade 2 sensory or motor neuropathy are not eligible Neuropathy (sensory or motor) less than or equal to grade 1 Able to perform motor/sensory tests Sensory/motor neuropathy ? Grade 2 Current or prior history of grade ? 2 peripheral sensory and/or motor neuropathy.