Current, clinically significant, active infection that in the opinion of the Investigator would make them an unfit participant in the trial Clinically significant active infection, in the judgment of the investigator Clinically significant active infection or uncontrolled medical condition Has a clinically significant active infection requiring systemic therapy. clinically significant active infection Has any clinically significant infection Any significant systemic infection within 4 weeks prior to dosing Active, clinically significant serious infection requiring treatment with antibiotics, anti-virals or anti-fungals. Active clinically significant infection requiring antibiotics Must not have known active or clinically significant hepatitis A, B or C infection. Active, clinically significant serious infection requiring treatment with antibiotics, anti-virals or anti-fungals. Active clinically significant uncontrolled infection Evidence of active tuberculosis or recent clinically-significant infection requiring systemic therapy. Active clinically significant infection Active clinically significant infection within 7-days of study treatment. No evidence of clinically significant active infection and no serious infection within the past month Active, clinically significant serious infection requiring treatment with antibiotics, anti-virals or anti-fungals Any clinically significant active infection that requires systemic treatment at the time of enrollment Evidence of active tuberculosis or recent (<1 week prior to first scheduled dosing) clinically significant infection requiring systemic therapy. Clinically significant active infection (e.g. tuberculosis, viral hepatitis, HIV) Active clinically significant infection requiring antibiotics Active and clinically significant systemic or localized infection. Other significant active infection. Active, clinically significant serious infection requiring treatment with antibiotics, anti-virals or anti-fungals. The Medical Monitor should be contacted for any uncertainties. Active, clinically significant serious infection requiring treatment with antibiotics, anti-virals, or anti-fungals. Other significant active infection. No evidence of a clinically significant active infection Active clinically significant uncontrolled infection Active clinically significant uncontrolled infection Active clinically significant infection Clinically significant active infection