Neurologic status\r\n* Patients with neurological deficits should have deficits that are stable for a minimum of 1 week prior to enrollment\r\n* Patients with seizure disorders may be enrolled if seizures are well controlled on an anti-epileptic drug that is not a strong inducer or inhibitor of CYP3A4/5 are eligible Patients with neurological deficits should have deficits that are stable for a minimum of 1 week prior to registration Patients with neurological deficits should have deficits that are stable for a minimum of 1 week prior to registration Patients with neurological deficits should have deficits that are completely stable for a minimum of 1 week (7 days) prior to enrollment INCLUSION CRITERIA FOR STRATUM C: Patients with neurological deficits should have deficits that are completely stable for a minimum of 1 week (7 days) prior to enrollment Patients with neurological deficits that are stable for a minimum of one week prior to registration Any neurologic deficits must be stable for >= 1 week Patients with neurological deficits should have deficits that are stable for a minimum of 1 week prior to registration Patients with neurological deficits should have deficits that are stable for a minimum of 2 weeks prior to registration Cerebrovascular accident (CVA) with persistent neurologic deficits occurring within 6 months prior to enrollment; persisting neurologic deficits from a CVA occurring over 6 months prior to enrollment are not necessarily grounds for exclusion Stable neurologic deficits on a stable dose of corticosteroids (if applicable) for at least 1 week before study enrollment At the time of study enrollment patients must have a life expectancy of greater than or equal to 2 months; neurologic deficits in patients with CNS tumors must have been relatively stable for a minimum of 1 week prior to study enrollment Neurologic deficits must have been relatively stable for a minimum of 1 week prior to study enrollment Patients with neurological deficits should be stable for a minimum of 1 week prior to enrollment Patients with neurological deficits should have deficits that are stable or improving for a minimum of 1 week prior to registration Neurologic status\r\n* Patients with neurological deficits should have deficits that are stable for a minimum of 1 week prior to enrollment\r\n* Patients with seizure disorders may be enrolled if seizures are well controlled Any active neurologic and/or psychiatric disease, history of significant head trauma followed by persistent neurologic deficits, or known structural brain abnormalities Patient with multiple, serious major neurologic deficits including encephalopathy. Any neurologic deficits must be stable for >= 1 week Neurologic deficits that are rapidly progressing: all neurologic signs and symptoms must have been stable for a week prior to first dose Neurological deficits must be stable on a fixed or decreasing dose of dexamethasone for >= 7 days before study enrollment Any neurologic deficits must be stable for >= 1 week Neurologic deficits that are rapidly progressing; all neurologic signs and symptoms must have been stable for a week prior to first dose DONOR: Severe neurologic deficits Patients with neurological deficits should have deficits that are stable for a minimum of 1 week prior to registration; this is to be documented at baseline Neurologic deficits: Patients with central nervous system (CNS) tumors must have stable neurological deficits for a minimum of 1 week prior to study entry For patients with CNS tumors (primary or metastatic), any baseline neurologic deficits (including seizure) must be stable for at least one week prior to study enrollment No orthopedic restrictions or neurologic deficits that would limit ability to complete the Power Protocol (based on the opinion of the investigator)