Significant history of medical conditions as listed in the protocol. Conditions that could interfere with treatment or protocol-related procedures Serious psychiatric or medical conditions that could interfere with treatment Patients who have any severe and/or uncontrolled medical conditions or other conditions that could affect their participation in the study such as: Presence of any severe and/or uncontrolled medical conditions or other conditions that could affect their participation in the study Patients must have no serious or uncontrolled medical conditions Medical or psychiatric conditions that preclude informed decision-making or compliance with the protocol treatment or follow-up Have serious preexisting medical conditions. Patients with a significant other medical conditions that would make them unsuitable for transplant Other serious uncontrolled medical conditions that the investigator feels might compromise study participation Have serious preexisting medical conditions Other concurrent severe and/or uncontrolled medical conditions Co-existing medical conditions with life expectancy < 5 years Serious psychiatric or medical conditions that could interfere with treatment Serious psychiatric or medical conditions that could interfere with treatment Participants who have any severe and/or uncontrolled medical conditions or other conditions that could affect their participation in the study Serious psychiatric or medical conditions that could interfere with treatment or protocol-related procedures. Other significant medical conditions must be well-controlled and stable in the opinion of the investigator for at least 30 days prior to Randomization Serious psychiatric or medical conditions that could interfere with treatment Patients with concurrent uncontrolled medical conditions that may interfere with their participation in the study or potentially affect the interpretation of the study data Patients with concurrent uncontrolled medical conditions that may interfere with their participation in the study or potentially affect the interpretation of the study data Other concurrent severe and/or uncontrolled medical conditions Patients with concurrent uncontrolled medical conditions that may interfere with their participation in the study or potentially affect the interpretation of the study data Serious psychiatric or medical conditions that could interfere with treatment Patients with other medical conditions or concomitant medications that in the opinion of the principal investigator may interfere with the therapeutic treatment. Patients with co-existing medical conditions with life expectancy < 2 years Patients who have any severe and/or uncontrolled medical conditions Serious psychiatric or medical conditions that could interfere with treatment Clinically relevant serious co-morbid medical conditions. Other serious illness or medical conditions Any severe and/or uncontrolled medical conditions or other conditions that, in the treating physician's opinion, could adversely impact their ability to participate in the study Subjects with certain medical conditions Patients must not have any severe and/or uncontrolled medical condition or other\n conditions that could affect their participation in the study, including, but not\n restricted to: Patients who have any severe and/or uncontrolled medical conditions or other conditions that could affect their participation in the study a known history of human immunodeficiency virus (HIV) seropositivity Unstable or severe intercurrent medical or psychiatric conditions as determined by the Investigator Medical Conditions Unstable or serious concurrent medical conditions in the previous 6 months. Evidence of any other medical conditions (such as psychiatric illness, infectious diseases, neurological conditions, physical examination or laboratory findings) that may interfere with the planned treatment, affect patient compliance or place the patient at high risk from treatment related complications Has certain serious illnesses or medical conditions Any severe and/or uncontrolled medical conditions or other conditions that could affect their participation in the study. Severe or uncontrolled medical conditions Evidence of any other medical conditions (such as psychiatric illness, peptic ulcer, etc.), physical examination or laboratory findings that may interfere with the planned treatment, affect patient compliance or place the patient at high risk from treatment-related complications Have other significant medical conditions well-controlled and stable in the opinion of the investigator for at least 30 days prior to Day 1 Certain serious illnesses or medical conditions Other concurrent serious diseases that may interfere with planned treatment including severe pulmonary conditions/illness Conditions that could interfere with treatment or protocol-related procedures Serious psychiatric or medical conditions that could interfere with treatment Serious psychiatric or medical conditions that could interfere with treatment Serious psychiatric illness (e.g., depression, psychosis) or medical conditions that could interfere with treatment Serious psychiatric or medical conditions that could interfere with treatment Other acute or chronic medical or psychiatric conditions. Patients with a significant other medical conditions that would make them unsuitable for transplant Other serious medical conditions that may be expected to limit life expectancy to less than 2 years (e.g., active liver cirrhosis) or a serious illness in medical opinion of the clinical investigator. Other serious uncontrolled medical conditions that the investigator feels might compromise study participation Patients who have any severe and/or uncontrolled medical conditions or other conditions that could affect their participation in the study Excluded medical conditions: Evidence of any other medical conditions (such as psychiatric illness, peptic ulcer, etc.), physical examination or laboratory findings that may interfere with the planned treatment, affect patient compliance or place the patient at high risk from treatment-related complications Other serious uncontrolled medical conditions that the investigator feels might compromise study participation Medical conditions that require hospitalization. Other serious uncontrolled medical conditions that the investigator feels might compromise study participation Patients with unstable or severe intercurrent medical conditions or laboratory abnormalities that would impart, in the judgment of the Medical Monitor, excess risk associated with study participation or study agent administration Patients must not suffer from medical or psychiatric conditions that would interfere with protocol compliance, the ability to provide informed consent, or assessment of response or anticipated toxicities Other concurrent severe and/or uncontrolled medical conditions. Any other serious uncontrolled medical disorders or psychological conditions that may interfere with study conduct Patients with serious psychiatric or medical conditions that could interfere with treatment Any other serious uncontrolled medical disorders or psychological conditions that may interfere with study conduct including but not limited to: clinically significant active infection Other serious medical conditions that may be expected to limit life expectancy to less than 2 years (e.g., active liver cirrhosis) or a serious illness in medical opinion of the clinical investigator. Serious psychiatric or medical conditions that could interfere with treatment Serious cardiac illness or medical conditions Any significant or severe medical conditions or psychiatric or social conditions that would preclude adherence to the protocol or compliance with study treatments Have serious preexisting medical conditions (left to the discretion of the investigator). Exclusionary concurrent medical conditions: Other serious uncontrolled medical conditions that the investigator feels might compromise study participation Conditions that could interfere with treatment and procedures Participants who have any severe and/or uncontrolled medical conditions or other conditions that could affect their participation in the study Serious psychiatric or medical conditions that could interfere with treatment Must not have a serious preexisting medical conditions or concomitant disorders. Patients with concurrent uncontrolled medical conditions that may interfere with their participation in the study Other conditions that could interfere with treatment Severe and/or uncontrolled medical conditions or other conditions that could affect their participation in the study such as: Serious psychiatric or medical conditions that could interfere with treatment Participants with severe and/or uncontrolled medical conditions or other conditions that could affect their participation in the study Patients must have no serious or uncontrolled medical conditions Uncontrolled or unstable medical conditions Serious psychiatric or medical conditions that could interfere with treatment Patients with any serious active or co-morbid medical conditions, laboratory abnormality, psychiatric illness, active or uncontrolled infections, or serious illnesses or medical conditions that would prevent the patient from participating or to be managed according to the protocol (according to investigator’s decision) Patients who have any severe and/or uncontrolled medical conditions Serious preexisting medical conditions Have serious preexisting medical conditions Any other serious uncontrolled medical disorders or psychological conditions Serious psychiatric or medical conditions that could interfere with treatment No co-existing medical conditions with life expectancy < 5 years Subjects who have used massage as a therapeutic modality (medical or psychological) at any point in their lives for the treatment of medical conditions Uncontrolled concurrent medical conditions that would limit compliance with study requirements There must be no uncontrolled active infections or medical conditions that the investigator feels will compromise the safety of the treatment and/or the assessment of the efficacy of therapy Patients with concurrent uncontrolled medical conditions that may interfere with their participation in the study or potentially affect the interpretation of the study data Subjects who have used massage as a therapeutic modality (medical or psychological) at any point in their lives for the treatment of medical conditions Able to list all current medications and medical conditions Conditions that could interfere with treatment or protocol-related procedures Patients who have any severe and/or uncontrolled medical conditions such as: Uncontrolled or unstable medical conditions Have serious preexisting medical conditions (left to the discretion of the investigator). Other Medical Conditions as noted in the protocol. Patients with other major uncontrolled medical conditions, e.g., recent myocardial infarction, stroke, diabetes, active hepatitis