Shortening fraction of >= 27% or Cardiac ejection fraction < 35% (or, if unable to obtain ejection fraction, shortening fraction of < 26%); ejection fraction is required if the patient is > 50 years of age, or history of cardiac disease or anthracycline exposure; patients with a shortening fraction < 26% may be enrolled if approved by a cardiologist Left ventricular ejection fraction >= 35%, or shortening fraction > 25% (for pediatric patients, a normal ejection fraction is required) Left ventricular ejection fraction > 45% (in children, shortening fraction > 26%) Left ventricular ejection fraction >= 40% or shortening fraction >= 25% Participants with clinically significant arrhythmias, complex congenital heart disease, or left ventricular ejection fraction (LVEF) <50 percent (%) or shortening fraction (SF) <=28% Left ventricular ejection fraction >= 45% or fractional shortening >= 28% Cardiac: Shortening fraction >= 28% Patients with impaired cardiac function as evidenced by ejection fraction < 35% (or, if unable to obtain ejection fraction, shortening fraction of < 26%) or cardiac insufficiency requiring treatment or symptomatic coronary artery disease; patients with a shortening fraction < 26% may be enrolled if approved by a cardiologist Left ventricular ejection fraction > 45% or shortening fraction > 26% TREATMENT WITH SJCAR19: Left ventricular ejection fraction > 40%, or shortening fraction >= 25% Adequate cardiac function defined as shortening fraction of ? 27% or ejection fraction ? 45% Left ventricular ejection fraction ? 45% or fractional shortening ? 28%, and no clinically significant electrocardiogram (ECG) findings Baseline left ventricular ejection fraction value <50% or shortening fraction of <27% Participants with known congestive heart failure, symptomatic or Left ventricular (LV) ejection fraction <50% or shortening fraction <27% and participants with congenital long QT syndrome, bradyarrhythmias, or QT interval (QTc)>480 milliseconds on at least 2 separate electrocardiograms (ECG). Left ventricular ejection fraction > 40%, or shortening fraction >= 25% PART 2 GROUP 1 INCLUSION CRITERIA: Shortening Fraction > 27% PART 2 GROUP 2A INCLUSION CRITERIA: Shortening Fraction > 27% PART 2 GROUP 3 INCLUSION CRITERIA: Shortening Fraction > 27% Shortening fraction >= 28% or ejection fraction (LVEF) >= 55%, as well as Shortening fraction >= 27% or ejection fraction >= 50%, no clinical congestive heart failure Adequate cardiac function defined as an ejection fraction > 50% or shortening fraction >= 27%. ECHO shortening fraction ? 27% Shortening fraction of >= 28% or an ejection fraction >= 50% Shortening fraction >= 27% or left ventricular ejection fraction >= 50% by echocardiogram within the past 1 year prior to registration PART 2: Shortening fraction > 26% Left ventricular ejection fraction > 40%, or shortening fraction >= 25% Left ventricular ejection fraction at rest must be >= 35%, or shortening fraction > 25% Left ventricular ejection fraction >= 35%, or shortening fraction > 25%, unless cleared by a cardiologist Left ventricular shortening fraction (LVSF) less than 25% Symptomatic coronary artery disease or ejection fraction < 40% or other cardiac failure requiring therapy (or, if unable to obtain ejection fraction, shortening fraction of < 26%); ejection fraction is required if the patient has a history of anthracyclines or history of cardiac disease; patients with a shortening fraction < 26% may be enrolled if approved by a cardiologist Has cardiac pathology: Participants with known congestive heart failure, symptomatic or left ventricular (LV) ejection fraction <50% or shortening fraction <27% and participants with congenital long QT syndrome, bradyarrhythmias, or QTc >480 msec on at least 2 separate electrocardiograms (ECGs). Shortening fraction > 26% Patients with known congestive heart failure, symptomatic or left ventricular (LV) ejection fraction < 50% or shortening fraction < 27% are not eligible Left ventricular ejection fraction >= 40% or fractional shortening >= 28% With impaired cardiac function as evidenced by ejection fraction < 35% (or, if unable to obtain ejection fraction, shortening fraction of < 26%) or cardiac insufficiency requiring treatment or symptomatic coronary artery disease; patients with a shortening fraction < 26% may be enrolled if approved by a cardiologist Left ventricular ejection fraction < 35% (or, if unable to obtain ejection fraction, shortening fraction of < 26%); ejection fraction is required if age > 50 years or there is a history of anthracycline exposure or history of cardiac disease; patients with a shortening fraction < 26% may be enrolled if approved by a cardiologist Left ventricular ejection fraction >= 40% or shortening fraction >= 25% Left ventricular ejection fraction >= 35% or shortening fraction > 25% Left ventricular fractional shortening < 30% Shortening fraction >= 28% Left ventricular ejection fraction < 40% or equivalent shortening fraction < 20% in pediatric patients Adequate cardiac function as defined as shortening fraction of > 27% OR ejection fraction of > 50% Shortening fraction > 26% Shortening fraction greater than or equal to 25% Prior left chest wall irradiation or a cumulative anthracycline dose of greater or equal to 300 mg/m^2, unless the ejection fraction or fraction shortening is within normal institutional limits, in which case the patient can be enrolled Cardiac ejection fraction < 35% (or, if unable to obtain ejection fraction, shortening fraction of < 26%); ejection fraction is required if age > 50 years or there is a history of anthracycline exposure or history of cardiac disease; patients with a shortening fraction < 26% may be enrolled if approved by a cardiologist Pediatric patients: normal left ventricular function with ejection fraction > 55% or shortening fraction >= 27% Adequate cardiac function defined as shortening fraction of >= 27% or ejection fraction >= 45% Patient must have a shortening fraction ? 27% by Echo or an ejection fraction ? 50% by MUGA. Reproductive Function Cardiac: Left ventricular ejection fraction at rest must be > 40%, or shortening fraction > 26%. Left ventricular ejection fraction >= 45% or fractional shortening >= 28% Left ventricular ejection fraction >= 40% or shortening fraction >= 25% Shortening fraction greater than or equal to 25% Adequate cardiac function defined as shortening fraction of >= 27% or ejection fraction >= 45% Cardiac Function a. Patient must have a shortening fraction ? 29% or an ejection fraction ? 40% by ECHO/MUGA. Left ventricular ejection fraction > 40%, or shortening fraction >= 25% Cardiac function: left ventricular ejection fraction (LVEF) >= 40% or shortening fraction (SF) >= 25% Left ventricular ejection fraction greater than 40%, or shortening fraction greater than or equal to 25% Left ventricular ejection fraction >= 35% or shortening fraction > 25%, unless cleared by a cardiologist Cardiac: left ventricular ejection fraction at rest must be greater than 40% or shortening fraction greater than 20% Left ventricular ejection fraction >= 35% or shortening fraction > 25% Resting ejection fraction < 50% or fractional shortening < 25% Subjects should have a normal ejection fraction (per institutional limits), no evidence of cardiac arrhythmias requiring therapy, and a fractional shortening of > 28% Left ventricular ejection fraction at rest must be >= 40%, or shortening fraction > 25% Left ventricular ejection fraction < 45% and in children-shortening fraction < 26% Left ventricular ejection fraction ? 40% or fractional shortening ? 28%