Ipsilateral diagnostic mammogram within 12 months of enrollment Ipsilateral breast had a previous cancer and/or prior in-field radiation Unilateral DCIS: contralateral normal mammogram ? 6 months of registration and ipsilateral breast imaging ? 90 days of registration (must include ipsilateral mammogram; can also include ultrasound or breast MRI) Any previous history of ipsilateral invasive breast cancer or ipsilateral DCIS; (patients with synchronous or previous ipsilateral LCIS are eligible) Any prior history, not including the index cancer, of ipsilateral invasive breast cancer or ipsilateral DCIS treated with radiation therapy; (patients with synchronous or previous ipsilateral LCIS are eligible) Any history, not including the index cancer, of ipsilateral or contralateral invasive breast cancer or ipsilateral or contralateral DCIS treated with radiation therapy (RT)\r\n* Note: Patients with synchronous or previous ipsilateral LCIS are eligible Recurrent ipsilateral breast cancer Open surgery in ipsilateral breast within 1 year. Radiation therapy to ipsilateral breast [Period 1] Previous history of ipsilateral invasive breast cancer or ipsilateral DCIS. (Patients with synchronous or previous ipsilateral LCIS are eligible.) Prior radiotherapy to the ipsilateral chest wall or ipsilateral breast or thorax; individuals with prior radiotherapy in the contralateral breast or chest wall are eligible No prior radiation to the ipsilateral breast History of ipsilateral breast cancer treated with radiation therapy Redo ipsilateral thoracotomy No prior radiation to the ipsilateral breast, a history of contralateral breast radiation is permitted History of ipsilateral cosmetic or reconstructive breast surgery Prior history of breast cancer or in-field radiation in the ipsilateral breast Prior radiotherapy to the ipsilateral chest wall or breast for any malignancy Prior or concurrent ipsilateral radiation therapy for invasive or noninvasive BC. Patients for whom radiotherapy for breast cancer is contraindicated because of medical reasons (e.g., connective tissue disorder or prior ipsilateral breast radiation) History of ipsilateral invasive breast cancer or ipsilateral ductal carcinoma in situ (DCIS); Note: patients with history of ipsilateral lobular carcinoma in situ (LCIS) are eligible Previous breast radiation on ipsilateral side or thoracic radiation on the ipsilateral side No prior history of lung resection on ipsilateral side Patients with a history of prior breast cancer in the ipsilateral breast treated with lumpectomy alone (no RT) are eligible as long as the other entry criteria for this study are met Prior ipsilateral breast or thoracic radiation for any condition Previous history of ipsilateral invasive breast cancer or DCIS. Any previously treated breast carcinoma or synchronous breast carcinoma in ipsilateral breast. Prior radiation therapy to the ipsilateral breast or thorax. No history of irradiation of the ipsilateral breast No evidence of other areas worrisome for cancer on physical examination and mammography of the ipsilateral breast A history of irradiation to the ipsilateral breast Clinically detected or palpable disease prior to biopsy in either breast or ipsilateral axilla Any previous history of ipsilateral invasive breast cancer or ipsilateral DCIS; (patients with synchronous or previous ipsilateral LCIS are eligible) Patients must not have received any prior treatment of any kind to treat the current breast cancer – including chemotherapy or endocrine therapy; in addition, any history of prior irradiation to the ipsilateral breast is excluded Previous radiation therapy to the ipsilateral breast Patients with a history of ipsilateral DCIS are eligible Previous radiation therapy to the ipsilateral breast Ipsilateral mammogram done greater than 6 months prior to study Patients must be a candidate for ipsilateral radiation therapy History of ipsilateral breast cancer Prior history of ipsilateral breast cancer Prior radiation therapy to the ipsilateral breast or thorax History of ipsilateral invasive breast cancer regardless of treatment or ipsilateral ductal carcinoma in situ (DCIS) treated with radiotherapy or contralateral invasive breast cancer at any time. Prior history of radiation therapy to the ipsilateral breast and/or regional nodes is not allowed (prior RT to other sites is permitted). Patients with ipsilateral treatment for DCIS or breast cancer within 12 months prior to entering this study Previous breast radiation on either side or thoracic radiation on the ipsilateral side Histological or cytological diagnosis of ES-SCLC (Note: Extensive-stage disease is defined as disease beyond the ipsilateral hemithorax, mediastinum and ipsilateral supraclavicular area and including malignant pleural or pericardial effusion or hematogenous metastases) Prior radiotherapy to the ipsilateral chest wall for any malignancy. Recurrent ipsilateral breast cancer Open surgery in the ipsilateral breast within 1 year of AVB-620 administration History of radiation therapy to ipsilateral breast Prior resection of jugular nodes ipsilateral to tumor Any prior history, not including the index cancer, of ipsilateral invasive breast cancer or ipsilateral ductal breast carcinoma in situ (DCIS) treated with radiation therapy; (Patients with synchronous or previous ipsilateral lobular breast carcinoma in situ [LCIS] are eligible) Patients that have had prior ipsilateral chestwall/thoracic radiation Previous radiation therapy to the ipsilateral breast Previous radiation to the ipsilateral breast History of prior ipsilateral lung interventions including:\r\n* Chest tube placement\r\n* Surgery\r\n* Pleurodesis\r\n* Radiation treatment Normal ipsilateral fibula without planned fibular osteotomy at time of surgery Prior radiation therapy to the ipsilateral breast/nodes or thorax Prior radiation therapy to the ipsilateral chest wall or thorax Patients with prior radiation to the breast/chest wall of the ipsilateral breast Prior receipt of ipsilateral breast or chest wall radiation Prior radiation therapy to the breast or ipsilateral regional nodes not allowed (a history of radiation therapy to other sites is permissible) Subject has a history of recurrent breast cancer in the ipsilateral breast Patients with a prior history of ipsilateral breast cancer Participants with prior history of ipsilateral breast carcinoma treated with BCS and radiation therapy Participants with prior history of ipsilateral breast carcinoma Prior history of breast cancer in the ipsilateral breast Patients must not have previous ipsilateral invasive breast cancer or DCIS Have a recurrence of ipsilateral breast cancer Prior history of ipsilateral breast cancer Prior ipsilateral breast cancer surgeries, mastectomies, breast reconstructions or implants. Prior ipsilateral reduction mammoplasties (breast reductions) performed less than 2 years prior to enrollment to this study. Prior breast malignancy of the ipsilateral breast. Patients with prior ipsilateral thoracic or breast radiation Patients with recurrent ipsilateral DCIS