For all patients:\r\n* Radiation dose should range from 4500 cGy to 6000 cGy\r\n* No treatment for this disease following radiation therapy
Prior radiation therapy with 400 cGY or more of TBI.
Prior radiation therapy with 400cGy or more of TBI.
Patient must be able to pass radiation evaluation (i.e.: able to receive 200 cGy)
Any prior therapeutic radiation therapy > 500 cGy has been delivered
Have received radiation therapy with concurrent temozolomide; total radiation dosage can range from 5400 to 6000 cGy administered in daily fractions of 150 to 200 cGy over 6 weeks, or the equivalent in a hypofractionated protocol (for example, 4000cGy in 15 fractions or 2500cGy in 5 fractions); patients who are MGMT negative do not need to have received temozolomide
Prior radiation doses equivalent to, or greater than, 8000 cGy to the target lesions at 200 cGy fractions at any timepoint
No thoracic radiation > 3000 cGy allowed
Patients may enter this study with or without salvage therapy for recurrent tumor; patients must have fully recovered from the toxic effects of any prior therapy; \r\n* Myelosuppressive chemotherapy and/or biologics: must not have received within 3 weeks of entry onto this study; (6 weeks in the case of mitomycin C or nitrosourea-containing therapy)\r\n* Radiation therapy (XRT): 6 weeks must have elapsed since completing radiation therapy to any site (6 months in the case of craniospinal, whole lung); patients are excluded if they have received local radiation which includes any of the following:\r\n** 1200 cGy to more than 33% of both kidneys (patient must have at least one kidney that has not exceeded the dose/volume of radiation listed)\r\n** 1800 cGy to more than 30% of liver and/or 900 cGy to more than 50% of liver\r\n** Prior MIBG therapy: should be at least 42 days from previous 131I-MIBG therapy and have recovered completely from all clinically significant treatment associated toxicities; patients must not exceed a lifetime cumulative injected activity of 54 mCi/kg for patients with neuroblastoma and 36 mCi/kg for patients with other MIBG avid diseases; patients must have demonstrated a response to prior MIBG therapy (either clinical, pathological and/or radiographic improvement)
Significant prior external beam dose-limiting radiation to a critical organ based on review of the prior radiation treatment records by the Radiation Oncology PI; patients who have had prior external beam radiation > 2000 cGy (at 180 to 200 cGy per day) to the lung will be ineligible; patients with ANY prior radiation to the heart are ineligible; patients with > 500 cGy to the kidney will be excluded from the study; Note: patients who have had electron beam therapy are still eligible and will be evaluated on a case by case basis by the Radiation Oncology PI
Patients who had prior radiation to more than 20% bone marrow containing areas or to any areas exceeding 2000 cGy
Patients will be ineligible if any prior therapeutic radiation therapy > 500 cGy has been delivered
Significant prior external beam dose-limiting radiation to a critical organ based on review of the prior radiation treatment records by the radiation oncology PI; patients who have had prior external beam radiation > 2000 cGy (at 180 to 200 cGy per day) to any portion of the lung will be ineligible; patients with ANY prior radiation to the heart are ineligible; patients with > 500 cGy to any portion of the kidney will be excluded from the study
Patients with no previous radiation or up to a maximum 2000 cGy to non thoracic-spine and rib bone lesions or < 20% of bone marrow are eligible for TMI conditioning regimen
Kidney: 500 cGy
Liver: 1000 cGy
Lungs: 500 cGy
Previous irradiation that precludes the safe administration of an additional dose of 200 cGy of TBI
Patients may have had prior systemic therapy without constraint on the number of prior treatment regimens except:\r\n* Patients may not have had > 450 mg/m^2 doxorubicin \r\n* Patients may not have had > 3000 centigray (cGy) to fields encompassing the entire pelvis
Patients undergoing a total body irradiation (TBI)-based conditioning regimen (TBI 1200 cGy)
Patients will be ineligible if any prior therapeutic radiation therapy > 200 cGy has been delivered to the target volume
Prior radiation therapy with 400 cGy or more of TBI; if 200 cGy of prior TBI then only 400 cGy of TBI on this protocol is permitted
Patients will be ineligible if any prior therapeutic radiation therapy > 200 cGy has been delivered to the target volume
Patients will be ineligible if any prior therapeutic radiation therapy > 200 cGy has been delivered to the central nervous system
Previous radiation therapy to more than 20% of bone marrow containing areas, or to any area exceeding 2000 cGy, is an exclusion
Patients who have received > 500 cGy radiation to the kidneys will be excluded from the study
Patients are not eligible if they have received local radiation which includes any of the following: 1200 centigray (cGy) to more than 33% of both kidneys (patient must have at least 1 kidney that has not exceeded the dose/volume of radiation listed) or 1800 cGy to more than 30% of liver and/or 900 cGy to more than 50% of liver; emergency local irradiation is allowed prior to study entry, provided the patient still meets eligibility criteria
One or more radiation treatment(s) to the chest wall or breast up to a maximum prior dose of 12,000 cGy in the hyperthermia field (not administered less than 28 days prior to enrollment).
Received >= 2000 centigray (cGy) radiation to the heart/chest
>= Ten years post-radiation therapy following an accumulated dose of >= 2000 cGY to the heart/chest
Histologic documentation of malignancy currently undergoing a course of RT (with or without chemotherapy) including the oral cavity and/or oropharyngeal area to a dose of at least 4500 cGy using more than 5 fractions (i.e., stereotactic body radiation therapy [SBRT] is not allowed)
Receiving a dose of radiation therapy greater than or equal to 6000 centigray (cGy) to one third of the oral cavity
Current diagnosis of cancer that supports the use of continuous definitive or adjuvant external-beam RT to the pelvis to a minimum dose of 4500 cGy with the following parameters:\r\n* The pelvis must be encompassed by the planned RT fields; the superior border may not lie inferior to the most inferior aspect of the sacroiliac joints; portions of the rectum may have special blocking, depending upon disease site\r\n* The total prescription dose must lie between 4500-5350 cGy (inclusive); a boost to primary tumor or tumor bed may be planned\r\n* Planned treatment is to be given 4-5 times per week on a one–treatment-per-day basis; the daily prescribed dose must lie between 170-210 cGy (inclusive) per day
Patient must be cleared pre-transplant by Radiation Oncology to be able to receive 400 cGy
Patients whose clinical treatment plans include a continuous course of external beam radiotherapy by intensity-modulated radiation therapy (IMRT) and/or image-guided radiation therapy (IGRT), given as a cumulative dose of 5000 – 7000 centigray (cGy) in single daily fractions of 180 - 200 cGy, combined with a concurrent course of weekly or tri-weekly cisplatin or carboplatin chemotherapy