Uncontrolled blood pressure despite medical treatment
Patients with uncontrolled high blood pressure (i.e., systolic/diastolic blood pressure > 99th percentile) are not eligible
Blood pressure that is not controlled despite > 2 oral agents (systolic blood pressure [SBP] > 160 and diastolic blood pressure [DBP] > 90 documented during the screening period with no subsequent blood pressure readings > 160/100)
Blood pressure >140/80
Adequately controlled blood pressure
Patients must demonstrate adequately controlled blood pressure at the time of study entry, as defined by a blood pressure =< 150/100 mmHg at study screening on at least one of two screenings conducted at least 24 hours apart; if blood pressure meets these guidelines on initial measurement, no subsequent measurement for screening is needed; blood pressure may be assessed by automated or manual methods by an appropriately trained clinician or nurse
Participants with uncontrolled high blood pressure, defined as a blood pressure during screening of >= 160/100 despite medical management
Have poorly controlled hypertension defined as blood pressure >160/90 on at least 2 repeated determinations on separate days within 2 weeks (14 days) prior to initiation of screening
Normotensive or well controlled blood pressure (<140/90).
Unstable hypertension (blood pressure > 160/100)
Blood pressure less than 140/90 mm Hg with or without anti-hypertensive therapy\r\n* Patients may be rescreened after initial ineligibility if due to elevated blood pressure, if adequately medically managed within approximately 30 days
Patients must be willing and able to check and record daily blood pressure readings when randomized to cediranib containing arm
Patients with a diagnosis of hypertension are required to have adequate blood pressure control prior to enrollment, defined as blood pressure =< 140/90 mmHg
Has uncontrolled hypertension defined as blood pressure > 150/90 on medication(s) by 2 blood pressure readings taken at least 1 hour apart.
Uncontrolled hypertension (defined as average systolic blood pressure >= 140 or average diastolic blood pressure >= 90, with blood pressure measured >= 3 times in the two weeks prior to enrollment) or diabetes
Arterial blood gas partial pressure carbon dioxide (pCO2) < 50 mmHg
Patients must be willing and able to check and record daily blood pressure readings; blood pressure cuffs will be provided to patients randomized to Arm III
Patients with high risk of cardiovascular event such as severe uncontrolled hypertension (> 170/110 systemic blood pressure on therapy), or pulmonary hypertension (greater than .5 systolic blood pressure)
Patients must have controlled blood pressure with a systolic blood pressure < 140 mmHg and diastolic < 90 mmHg (for patients with an elevated initial blood pressure (BP) reading [hypertensive range], a repeat measurement at least 2 minutes later should be performed, and the two readings should be averaged to obtain a BP reading); any hypertensive at-home blood pressure reading will be confirmed in clinic; patients on anti-hypertensive medications are eligible, if blood pressure is controlled; study drug dosing will be interrupted for any reading >= 160/100
Stable blood pressure and circulation, not requiring pressor support
Patients who are currently receiving a beta-blocker for another medical condition will be excluded from this study; patients with extremes of blood pressure (e.g., systolic blood pressure [SBP] > 150 or < 100) may be excluded from participation if the treating physician feels that this medical condition has not been adequately addressed by the patient’s primary care physician
Stable blood pressure and circulation not requiring pressor transport
Adequately controlled blood pressure
A common skin contaminant cultured from 2 or more blood cultures drawn on the same or consecutive calendar days from a subject with fever (greater than 38.0 degrees C), chills, or hypotension (systolic blood pressure less than 90 mmHg);
Symptoms of uncontrolled intracranial pressure
Uncontrolled arterial hypertension despite appropriate medical therapy (systolic blood pressure > 160 or diastolic blood pressure > 100)
Patients must be willing and able to check and record daily blood pressure readings if receiving cediranib
Inability to home monitor blood pressure
Blood pressure =< 140/90 within 10 days of registration (must be taken and recorded by a health care professional); Note: if the systolic blood pressure is > 140 and/or diastolic blood pressure is > 90 at the time of registration, the patient’s blood pressure must be controlled; systolic blood pressure must be < 140 and diastolic blood pressure must be < 90 on at least 2 separate measurements prior to the start of treatment, and the treating physician must believe that this is feasible in order to enroll the patient
Uncontrolled hypertension: systolic blood pressure >= 160, diastolic blood pressure >= 90
Have uncontrolled hypertension (systolic blood pressure greater than 150 or diastolic blood pressure greater than 100) or history of congestive heart failure (AHA Grade 2 or higher).
Adequately controlled blood pressure
Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to enrollment\r\n* Sustained systolic blood pressure > 160 or diastolic blood pressure > 100 despite medical therapy; sustained blood sugar > 300 despite medical therapy\r\n* Chronic hypertension or diabetes on appropriate medical therapy does not constitute an exclusion criterion
Willingness and ability to check and record daily blood pressure readings; blood pressure cuffs will be provided to patients
Controlled blood pressure (systolic blood pressure < 140 and diastolic blood pressure < 90) on no more than three anti-hypertensive agents; drug formulations containing two or more anti-hypertensive agents will be counted based on the number of active agents in each formulation
For patients with hypertension at baseline with a systolic pressure greater than 140 or a diastolic pressure greater than 90
Blood pressure < 160/90
Blood pressure that is not controlled despite > 2 oral agents (systolic blood pressure [SBP] > 160 and diastolic blood pressure [DBP] > 90 documented during the screening period with no subsequent blood pressure readings < 160/100)
No evidence of preexisting uncontrolled hypertension as documented by 2 baseline blood pressure readings taken at least 1 hour apart; the baseline systolic blood pressure readings must be =< 140, and the baseline diastolic blood pressure readings must be =< 90; patients whose hypertension is controlled by antihypertensive therapies are eligible
Patients must be willing and able to check and record daily blood pressure readings
Adult patients with hypertension not controlled by medical therapy (hypertension defined as systolic blood pressure > 150 mmHg or diastolic pressure > 90 mmHg despite optimal medical management); pediatric patients must have blood pressure (BP) within normal limits (WNL) for age; NOTE: blood pressure within the upper limit of normal is defined as: blood pressure =< the 95th percentile for age, height, and gender, and not be receiving medication for treatment of hypertension
Uncontrolled hypertension (blood pressure greater than 140/90 mmHg on at least 2 measurements on sequential visits, despite blood pressure medication)
A past history of, or current uncontrolled hypertension. Blood pressure must be adequately controlled prior to dosing with VS-5584.
The participant has high blood pressure or diabetes that is not well-controlled with medication
Uncontrolled hypertension (systolic blood pressure > 150 or diastolic blood pressure > 100)
Oxygen partial pressure (pO2) < 60% or carbon dioxide partial pressure (pCO2) >= 50 on room air arterial blood gas
Participants with uncontrolled sustained hypertension which will be defined as systolic blood pressure > 140, and diastolic blood pressure > 90, even with use of anti-hypertensive medications
Uncontrolled cardiopulmonary dysfunction (e.g., high blood pressure, serious cardiac\n             arrhythmia)
Blood pressure greater than 170/90 or two standard deviations from normal based on age and weight nomogram on three separate measurements
Participants must have a baseline blood pressure of 160/90 or less; participants requiring medicines to control blood pressure are eligible
Uncontrolled arterial hypertension despite appropriate medical therapy (defined as systolic blood pressure > 160 or diastolic blood pressure > 100)
Abnormal systolic blood pressure, diastolic blood pressure and/or heart rate
Patients with New York Heart Association (NYHA) grade 2 or higher congestive heart failure, myocardial infarction within the last 6 months, unstable angina pectoris, or arterial thrombotic event with the past 12 months, uncontrolled hypertension (systolic blood pressure > 150 and/or diastolic blood pressure > 100 on antihypertensive medications; patients not on medication for high blood pressure who are found to have systolic blood pressure [SBP] > 150 and/or diastolic blood pressure [DBP] > 100 should have 3 documented episodes of elevated blood pressure before being considered ‘uncontrolled’, if they have 3 documented episodes of elevated blood pressure, then can be started on antihypertensive medications; patients currently on antihypertensive medications with elevated blood pressures as defined above may have their medications adjusted; if patients have persistent [3 episodes] of high blood pressure despite medication adjustment they will be considered ineligible for study participation; each measured episode should be 24 hours apart), prior history of hypertensive crisis or hypertensive encephalopathy, uncontrolled or clinically significant arrhythmia, grade II or greater peripheral vascular disease or prior history of stroke or transient ischemic attack (TIA); patient must have a pretreatment oncocardiology echocardiogram with left ventricular ejection fraction (LVEF) above lower limit of normal
Controlled blood pressure, defined as blood pressure =< 140/90 on average (3 separate readings taken at screening visit in a relaxed clinical environment and averaged)
Inability to home monitor blood pressure
Patients not achieving adequate blood pressure in spite of antihypertensive therapy for control of blood pressure
Patients must have normal blood pressure or well-controlled hypertension.
Poorly controlled high blood pressure
Severe untreated sleep apnea (treatment is defined as therapy with continuous positive airway pressure [CPAP], bilevel positive airway pressure [BiPAP], adaptive servo ventilation [ASV], or other positive air pressure device)
Presence of conditions where significant elevations in blood pressure would be a serious hazard
Stage 2 hypertension or greater (systolic blood pressure > 160 and/or diastolic blood pressure > 100)
Resting blood pressure and/or heart rate within normal limits
Resting blood pressure and/or heart rate outside normal limits
Resting blood pressure > 160/100
Uncontrolled hypertension >= 2 times as noted in medical history (diastolic blood pressure > 100, systolic > 160) =< 90 days prior to registration
History of intolerance to negative pressure wound therapy
Use of any other blood pressure lowering medication for treatment of hypertension, within 30 days of randomization
Pressure readings >= 140/90 mm Hg, as defined by the 7th Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure, will be deemed ineligible to participate and excluded from the study; they will be referred to their family physician or community services; those ineligible based on their initial blood pressure reading are allowed to participate if they provide a letter from a physician who will continue to monitor the participant during the research study
Uncontrolled hypertension (defined as blood pressure in adults > 150/95)\r\n* Patients on anti-hypertensive medications are eligible if blood pressure is controlled
Patients with a history of severely impaired autonomic control of blood pressure
Use of any other blood pressure lowering medication for treatment of hypertension within 30 days of enrollment except calcium channel blockers and diuretics
Uncontrolled severe hypertension at enrollment. Severe hypertension is defined as a systolic or diastolic blood pressure (BP) > 5 mm Hg above the 95th percentile as defined by the National High Blood Pressure Education Program Working Group (NHBPEP) established guidelines for the definition of normal and elevated blood pressure in children
High blood pressure
High blood pressure
Participants with a blood pressure >= 140/90 at the time of baseline testing
Blood pressure > 140/90 at baseline by home monitoring
Patients with hypertension not adequately controlled by medication (i.e. systolic blood pressure >= 150 and/or diastolic blood pressure >= 90 on at least two separate readings)
Uncontrolled high blood pressure (BP) >= 160/100; persons can be re-screened after controlled
high blood pressure (defined as systolic blood pressure over 165 or diastolic blood pressure over 100),
Poorly controlled hypertension, with blood pressure at study entry > 160/100; the addition of anti-hypertensives to control blood pressure is allowed for eligibility determination
Poorly controlled hypertension, with blood pressure at study entry > 160/100
Systolic blood pressure < 90 prior to propranolol
Current use of medications to control blood pressure or improve cardiac output
Systolic blood pressure greater than 145 and diastolic blood pressure greater than 90
Blood pressure <= Grade 1 (hypertensive participants are permitted if their blood pressure is controlled to <= Grade 1 by hypotensive medications and glycosylated HbA1C <= 6.5%).