Urine M-Protein >= 200 mg/24 hours, OR Urine M-protein ?200 mg/24 hours ; or Urine M-protein level >= 200 milligram per 24 hours (mg/24 hours); or Urine M-protein ?200 mg/24 hours (any immunoglobulin heavy chain type measured by PEP). Urine M-protein > 200 mg/24 hours Serum M-protein level >=1.0 gram per deciliter (g/dL) or urine M-protein level >=200 mg/24 hours; or Urine M-protein ?200 mg/24 hours and must have documented MM isotype by immunofixation (central laboratory). Urine M-protein ? 200 mg/24 hours OR Urine M protein ? 200 mg/24 hours), or Urine M-protein =< 1 g/24 hours (MM patients only) urine M-protein ?200 mg/24 hours. Urine M-protein ?200 mg/24 hours, OR urine M-protein ? 200 mg/24 hours, Urinary protein >2+ possibly indicative of renal disease. If the 24 hours urine protein shows a result of < 100 mg protein, subject can be eligible; Urine M protein ? 200 mg/24 hours IgG MM: Serum monoclonal paraprotein (M-protein) level ? 1.0 g/dl or urine Mprotein level ? 200 mg/24 hours- IgA MM: Serum M-protein level ? 0.5 g/dl or urine M-protein level ? 200 mg/24 hours IgM MM (IgM M-protein plus lytic bone disease documented by skeletal survey plain films): Serum M-protein level ? 1.0 g/dl or urine M-protein level ? 200 mg/24 hours IgD MM: Serum M-protein level ? 0.05 g/dl or urine M-protein level ? 200 mg/24 hours Light chain MM: Serum M-protein level ? 1.0 g/dl or urine M-protein level ? 200 mg/24 hours 5. Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2 6. Females of childbearing potential (FCBP1) must: Urine M protein ?200 mg/24 hours; Urine protein =< 1+ on urine dipstick (if 2+ seen on first test, re-test at least 24 hours later), within 14 days of study registration Urine M-protein ? 200 mg/24 hours Relapsed and/or refractory multiple myeloma with measurable disease, as defined by one or both of the following (assessed within 14 days prior to initiation of therapy): a) serum myeloma protein (M-protein) >= 0.5 g/d; b) urine Bence-Jones protein >= 200 mg/24 hours Urine M-protein ? 200 mg/24 hours. Urine M-protein ? 200 mg/24 hours Urine M-protein ? 200 mg/24 hours OR Urine M-protein ? 200 mg/24 hours, or Urine Bence-Jones protein ? 200 mg/24 hours IgG multiple myeloma: Serum monoclonal paraprotein (M-protein) level ? 1.0 g/dl or urine M-protein level ? 200 mg/24 hours IgA multiple myeloma: Serum M-protein level ? 0.5 g/dl or urine M-protein level ? 200 mg/24 hours IgM multiple myeloma (IgM M-protein plus lytic bone disease documented by skeletal survey plain films): Serum M-protein level ? 1.0 g/dl or urine M-protein level ? 200mg/24hours IgD multiple myeloma: Serum M-protein level ? 0.05 g/dl or urine M-protein level ? 200 mg/24 hours Light chain multiple myeloma: Serum M-protein level ? 1.0 g/dl or urine M-protein level ? 200 mg/24 hours AND are at least 65 years of age or older or, if younger than 65 years of age, are not candidates for stem cell transplantation because: Urinary M-protein excretion at least 200 mg/24 hours; or Urinary M-protein excretion at least 200 mg/24 hours; or Urine protein =< 1+ on urine dipstick (if 2+ seen on first test, re-test at least 24 hours later) (within 14 days of study registration) Urine M-protein >=200 mg/24 hours.