Patients with CNS involvement, including leptomeningeal carcinomatosis, which is either asymptomatic or previously-treated and controlled, are allowed History of leptomeningeal carcinomatosis Patients must be diagnosed with leptomeningeal carcinomatosis. History of leptomeningeal carcinomatosis History of leptomeningeal carcinomatosis. Leptomeningeal carcinomatosis or other central nervous system (CNS) metastases History of leptomeningeal carcinomatosis History of leptomeningeal carcinomatosis History of leptomeningeal carcinomatosis Uncontrolled metastases to the central nervous system (CNS) or cytological/radiographic evidence of leptomeningeal carcinomatosis. Participants with brain metastases (other than leptomeningeal carcinomatosis) are eligible provided they do not require ongoing steroids and have shown clinical and radiographic stability for at least 28 days after definitive therapy. Primary glioblastoma is allowed. History of leptomeningeal carcinomatosis History of leptomeningeal carcinomatosis. History of leptomeningeal carcinomatosis History of leptomeningeal carcinomatosis History of leptomeningeal carcinomatosis History of leptomeningeal carcinomatosis History of leptomeningeal carcinomatosis or brain metastasis. History of leptomeningeal carcinomatosis History of leptomeningeal carcinomatosis Leptomeningeal carcinomatosis, diagnosed on cytology or appropriate imaging History of leptomeningeal carcinomatosis History of leptomeningeal carcinomatosis History of leptomeningeal carcinomatosis History of leptomeningeal carcinomatosis History of leptomeningeal carcinomatosis History of leptomeningeal carcinomatosis Symptomatic and uncontrolled metastasis in the central nervous system or leptomeningeal or lymphangitic carcinomatosis Leptomeningeal carcinomatosis History of leptomeningeal carcinomatosis Central nervous system (CNS) metastases including a history of leptomeningeal carcinomatosis History of leptomeningeal carcinomatosis or uncontrolled seizures History of leptomeningeal carcinomatosis or brain metastasis History of leptomeningeal carcinomatosis Cohort A only: Patients with leptomeningeal carcinomatosis are excluded. Other\n central nervous system (CNS) metastases are only permitted if treated, asymptomatic,\n and stable (not requiring steroid for at least 4 weeks prior to the start of study\n treatment). Cohort B only: Patients with CNS metastases or leptomeningeal\n carcinomatosis are excluded. Leptomeningeal carcinomatosis as only site of CNS disease Subjects with leptomeningeal carcinomatosis are not permitted Subject has peritoneal carcinomatosis. Lymphangitic carcinomatosis. History of carcinomatosis meningitis Diagnosis of leptomeningeal carcinomatosis Brain metastases or history of leptomeningeal carcinomatosis History of leptomeningeal carcinomatosis History of leptomeningeal carcinomatosis Unstable CNS metastases or leptomeningeal carcinomatosis not considered radiographically stable Leptomeningeal carcinomatosis as the only site of CNS involvement History of leptomeningeal carcinomatosis History of leptomeningeal carcinomatosis History of leptomeningeal carcinomatosis History of leptomeningeal carcinomatosis