Patients who have undergone major surgery =< 4 weeks prior to starting study drug or who have not recovered from side effects of such therapy prior to registration Patients who have undergone major surgery =< 4 weeks prior to starting study treatment or who have not recovered from side effects of such procedure Patients who have undergone major surgery within the 2 weeks prior to starting study treatment or who have not fully recovered from previous surgery Patients who have undergone surgery =< 3 weeks or who have not recovered from side effects of this procedure prior to receiving study drug Patients who have undergone major surgery =< 2 weeks prior to starting study drug or who have not recovered from the side-effects of surgery Patients who have undergone major surgery =< 4 weeks prior to starting study drug or who have not recovered from side effects of such therapy Patient who has undergone major surgery =< 4 weeks prior to starting study treatment or who has not recovered from side effects of such procedure Patients who have undergone major surgery =< 3 weeks prior to starting study drug or who have not recovered from side effects of such procedure Have undergone major surgery =< 4 weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery =< 2 weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients had a major surgery within 3 weeks prior to study entry or who have not recovered from side effects of such procedure Patients who have undergone major surgery < 4 weeks of initiation of study medication or who have not recovered from side effects of such procedure Patients who have undergone major surgery <4 weeks prior to starting study drug. Patients who have undergone major surgery =< 2 weeks prior to starting study drug or who have not recovered from side effects of such therapy Major surgery 21 days or less prior to starting study drug or has not recovered from adverse effects from such procedure. Patients who have undergone major surgery =< 3 weeks prior to starting study drug or who have not recovered from side effects of such procedure Prior major surgery =< 3 weeks before study drug or not recovered from side effects of such procedure Participants who have undergone major systemic surgery =< 2 weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery =< 4 weeks prior to starting study treatment or who have not recovered from side effects of such procedure Patients who have undergone major surgery within 4 weeks prior to starting the study treatment Patients who have undergone major surgery =< 4 weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery =< 2 weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery =< 4 weeks prior to starting study treatment, who have not recovered from side effects of such procedure Major surgery =< 2 weeks prior to starting a study drug or who have not recovered from side effects of such therapy Patients with major surgery within 3 weeks prior to study entry or who have not recovered from side effects of such procedure Patients had a major surgery within 3 weeks prior to study entry or who have not recovered from side effects of such procedure Patients who have undergone major surgery =< 4 weeks prior to registration or have not recovered from side effects of such procedure are not eligible for participation Participants who have undergone major surgery =< 4 weeks prior to starting study drug or who have not recovered from side effects of the surgery Patient who has undergone major surgery =< 4 weeks prior to starting study treatment or who has not recovered from side effects of such procedure Patients who have undergone major surgery =< 2 weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery =< 2 weeks prior to registration to study or who have not recovered from the side-effects of surgery Patients who have undergone major surgery =< 4 weeks prior to registration or who have not recovered from side effects of such procedure are not eligible for participation Participants who have undergone major surgery =< 4 weeks prior to starting study drug or who have not recovered from side effects of the surgery Patients who have undergone major surgery =< 4 weeks prior to starting study treatment, who have not recovered from side effects of such procedure Participants who have undergone any major surgery =< 2 weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery =< 2 weeks prior to starting study drug or who have not recovered from side effects of such therapy Participants who have undergone any major surgery =< 2 weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery or radiotherapy ? 3 weeks prior to starting study drug or who have not recovered from side effects of such procedure; Patients who have undergone major surgery =< 4 weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery =< 4 weeks prior to starting study drug or who have not recovered from side effects of such therapy Have undergone major surgery =< 2 weeks prior to starting BKM120 or BYL719 or have not recovered from side effects of such therapy Patients who have undergone major surgery =< 4 weeks prior to starting treatment or who have not recovered from side effects of such therapy Major surgery =< 3 weeks prior to starting study drug or who have not recovered from side effects of such procedure Patients who have undergone major surgery =< 2 weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery =< 4 weeks prior to starting study drug or who have not recovered from side effects of such therapy Major surgery =< 2 weeks prior to starting a study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery =< 3 weeks prior to starting study drug or who have not recovered from side effects of such procedure Major surgery =< 2 weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery =< 4 weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery =< 2 weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery =< 4 weeks prior to starting study drug or who have not recovered from side effects of such therapy Patients who have undergone major surgery ? 4 weeks prior to starting study drug or who have not recovered from side effects of such therapy A history of gastrointestinal malabsorption or having undergone surgery requiring gastrointestinal anastomoses within four weeks of starting therapy or who have not recovered from major surgery within three weeks of starting therapy Patients who have undergone any major surgery within 2 weeks prior to starting study drug or who have not adequately recovered from previous surgery Patients who have undergone major surgery =< 3 weeks prior to starting study drug or who have not recovered from side effects of such procedure