Active collagen vascular disease, specifically dermatomyositis with a creatinine phosphokinase (CPK) level above normal or with an active skin rash, systemic lupus erythematosus, or scleroderma Active collagen vascular disease, specifically dermatomyositis with a creatine phosphokinase (CPK) level above normal or with an active skin rash, systemic lupus erythematosus, or scleroderma History of connective tissue disorders (eg, lupus, scleroderma, arteritis nodosa). Bilateral hip prostheses, inflammatory bowel disease or connective tissue disorder such as active scleroderma or lupus (radiotherapy contraindications) Active connective tissue disorders, such as lupus or scleroderma that in the opinion of the treating physician may put the patient at high risk for radiation toxicity; Active systemic lupus or scleroderma Collagen vascular disease, specifically dermatomyositis with a CPK level above normal or with an active skin rash, systemic lupus erythematosis, or scleroderma. Patients with active lupus or scleroderma Known contraindications to radiation such as inflammatory bowel disease, active systemic lupus or scleroderma, or radiation hypersensitivity syndrome (ataxia telangiectasia or Fanconi’s anemia) Active collagen vascular diseases, such as: systemic lupus erythematous, scleroderma, or dermatomyositis Patients with active collagen vascular disease (CVD), specifically systemic lupus erythematosus or scleroderma; patients with a history of CVD without evidence of active disease are eligible for enrollment at the discretion of the study PI Active lupus or active scleroderma A diagnosis of active scleroderma, lupus, or other rheumatologic disease which in the opinion of the treating radiation oncologist precludes safe radiation therapy. Has a diagnosis of active scleroderma or lupus or any other autoimmune disease that by the opinion of the treating radiation oncologist would put the patient at unacceptable risk of toxicity Subjects must not have history of scleroderma or lupus erythematosus with either cutaneous manifestation or requiring active treatment Patients who have a history scleroderma or other active connective tissue disease Has a diagnosis of scleroderma GROUP 4: Diffuse scleroderma with disease duration =< 2 years and skin score >= 30 Active connective tissue disorders, such as lupus or scleroderma, that in the opinion of the treating physician may put the patient at high risk for radiation toxicity Active systemic lupus, erythematosus, or any history of scleroderma, dermatomyositis with active rash Has a diagnosis of active scleroderma, lupus, or other rheumatologic disease which in the opinion of the treating radiation oncologist precludes safe radiation therapy Patients with collagen vascular disease, specifically dermatomyositis with a creatine phosphokinase (CPK) level above normal or active skin rash, systemic lupus erythematosus, or scleroderma History of active connective tissue disease (scleroderma) Patients with active lupus or scleroderma are ineligible Has a diagnosis of active scleroderma, lupus, or other autoimmune disease which by the opinion of the treating radiation oncologist precludes safe radiation therapy History of active connective tissue disease (scleroderma) or idiopathic pulmonary fibrosis Collagen vascular disease, specifically dermatomyositis with a creatine phosphokinase (CPK) level above normal or with an active skin rash, systemic lupus erythematosus, or scleroderma Significant infection or other co-existing medical condition that would preclude protocol therapy such as pregnancy, HIV/AIDS or collagen vascular diseases specifically systemic lupus erythematosus, scleroderma, or dermatomyositis. Active lupus or scleroderma Documented diagnosis of collagen vascular disease, specifically dermatomyositis with a creatinine phosphokinase (CPK) level above normal or with an active skin rash, systemic lupus erythematosus, or scleroderma Patients with collagen vascular diseases, specifically systemic lupus erythematosus, scleroderma, or dermatomyositis Any patient with active connective tissue disease such as lupus, dermatomyositis Diagnosis of scleroderma Diagnosis of active lupus Scleroderma or active connective tissue disease Active connective tissue disorders, such as lupus or scleroderma Active connective tissue disorders, such as lupus or scleroderma, which in the opinion of the treating physician may put the patient at high risk for immunologic toxicity Current treatment for active connective tissue disorders, such as lupus or scleroderma Diagnosis of systemic lupus erythematosus, scleroderma, or dermatomyositis Patient must not have active systemic lupus erythematosus, or any history of active scleroderma, or dermatomyositis with active rash Active systemic lupus erythematosus, or any history of active scleroderma, dermatomyositis with active rash Active connective tissue disorders, such as lupus or scleroderma, that in the opinion of the treating physician may put the patient at high risk for radiation toxicity Active connective tissue disorders, such as lupus or scleroderma Patients with active inflammatory bowel disease or collagen vascular disease –systemic lupus erythematosus (SLE), scleroderma Patients with collagen vascular disease, specifically dermatomyositis with a creatine phosphokinase (CPK) level above normal or active skin rash, systemic lupus erythematosus, or scleroderma Collagen vascular disease (lupus, scleroderma, rheumatoid arthritis) Scleroderma or active connective tissue disease Patients with history of collagen vascular disease, specifically dermatomyositis with a creatine phosphokinase (CPK) level above normal or active skin rash, systemic lupus erythematosus, or scleroderma Diagnosis of scleroderma. History of lupus or scleroderma History of scleroderma and systemic lupus erythematosus which increases the risk of toxicity from radiation treatment History of connective tissue disorders (eg, lupus, scleroderma, arteritis nodosa). Patients who have contraindications to radiotherapy, such as scleroderma, dermatomyositis, or severe cutaneous manifestations of systemic lupus erythematosus (SLE) Any patient with active connective tissue disease such as lupus, dermatomyositis No active collagen vascular diseases, such as: systemic lupus erythematous, scleroderma, or dermatomyositis Connective tissue disorders, e.g. scleroderma, that in the opinion of the treating physicians is a contraindication to radiation therapy Patients with scleroderma or discoid lupus Collagen vascular disease such as lupus, or scleroderma Patients with connective tissue disorders specifically systemic lupus erythematosus, scleroderma, or dermatomyositis History of Sjogren’s, lupus or scleroderma Women with scleroderma or discoid lupus Active systemic lupus or scleroderma Co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would interfere significantly with whole-breast irradiation (such as connective tissue disorders, lupus, or scleroderma) Active collagen vascular disease, specifically dermatomyositis with a creatine kinase (CPK) level above normal or with an active skin rash, systemic lupus erythematosus, or scleroderma