History of cerebrovascular disease No history of arterial thrombotic events such as myocardial infarction (MI), unstable angina pectoris or any ischemic or hemorrhagic cerebrovascular accident (CVA) within past 6 months 12. Subjects with any other concurrent, uncontrolled illness, including known psychiatric or substance abuse disorders which may interfere with the ability of the subject to cooperate and participate in the trial. Other examples of such conditions would include unstable angina, myocardial infarction (MI) or cerebrovascular accident (CVA) within 6 months of study entry. Subjects with other uncontrolled medical conditions, e.g. myocardial infarction, cerebrovascular accident, diabetes or hypertension. History of cerebrovascular accident (CVA) within 6 months prior to randomization or that is not stable History of cerebrovascular accident (CVA) within 6 months prior to randomization or that is not stable Severe uncontrolled cardiac disease within 6 months of study entry, including but not limited to uncontrolled hypertension; unstable angina; myocardial infarction (MI) or cerebrovascular accident (CVA). History of arterial thromboembolic event in past 6 months (including cerebrovascular accident [CVA], myocardial infarction [MI]) Myocardial infarction or cerebrovascular accident (CVA) within 6 months. History of a venous thromboembolic event, cerebrovascular accident (CVA), hepatic impairment, or heart failure History of cerebrovascular accident (CVA), myocardial infarction or unstable angina within the previous 6 months before starting therapy. Prior cerebrovascular accident (CVA) with persistent neurological deficit No cerebrovascular accident (CVA) within 6 months, no myocardial infarction (MI) within 6 months History of myocardial infarction or cerebrovascular accident within 6 months of enrollment date History of cerebrovascular disease No cerebrovascular accident (CVA) within 6 months, no recent myocardial infarction (MI) within 6 months Patients with clinically significant cardiovascular disease: History of CVA (cerebrovascular accident) within 6 months, myocardial infarction or unstable angina within 6 months, unstable angina pectoris Patients with clinically significant cardiovascular disease: history of cerebrovascular accident (CVA) within 6 months, myocardial infarction or unstable angina within 6 months, or unstable angina pectoris History of cerebral vascular accident (CVA), myocardial infarction or unstable angina within the previous six months before starting therapy Severe cerebrovascular disease (multiple CVA or CVA within 6 months) Known history of cerebrovascular accident, myocardial infarction, or intracranial hemorrhage within 2 months of enrollment. History of cerebrovascular accident, myocardial infarction or unstable angina within the previous 6 months before starting therapy Seizure or cerebrovascular accident (CVA) in the last year Clinically significant cardiomyopathy or cardiac complications, including recent myocardial infarction or cerebrovascular accident within one year, and/or unstable or uncontrolled angina Patients with a known history of myocardial infarction or cerebrovascular accident are not eligible Patients with any unstable medical issue (including cardiac issues as above, active treatment for pulmonary embolism, cerebrovascular accident [CVA], renal or hepatic insufficiency, active infection/sepsis requiring IV antibiotics) Patient must have no history of cerebrovascular accident (CVA) within 6 months of randomization History of cerebrovascular accident within the past 6 months Cerebral Vascular Accident (CVA) within 3 months prior to consent. Severe cerebrovascular disease (multiple CVA or CVA within 6 months) Patients with a history of myocardial infarction, unstable angina, or cerebrovascular accident < 6 months prior to registration Prior cerebrovascular accident (CVA) with persistent neurological deficit Myocardial infarction or cerebrovascular accident within 6 months prior to study registration History of cerebrovascular accident (CVA), myocardial infarction or unstable angina within the previous 6 months before starting therapy No CVA within 6 months, no MI within 6 months History of documented myocardial infarction or cerebrovascular accident Cerebrovascular accident within prior 6 months Patients with clinically significant cardiovascular disease: history of cerebrovascular accident (CVA) within 6 months, myocardial infarction or unstable angina within 6 months, or unstable angina pectoris History of cerebral vascular accident (CVA) within 6 months Substantial central nervous system (CNS) disease including\r\n* History of CNS bleeding\r\n* Mass lesions in the brain\r\n* Uncontrolled seizure disorder\r\n* Recent history of cerebrovascular accident (CVA) (e.g. within the past 6 months) History of a stroke or cerebrovascular accident (CVA) within 6 months Subject has history of severe/unstable angina, myocardial infarction or cerebrovascular accident within 6 months prior to the planned first dose of study drug. Subject has history of severe/unstable angina, myocardial infarction or cerebrovascular accident within 6 months prior to the planned first dose of study drug. Subject has history of severe/unstable angina, myocardial infarction or cerebrovascular accident within 6 months prior to the first dose of study drug. Severe cerebrovascular disease (multiple cerebrovascular accidents [CVAs] or CVA within 6 months) History of cerebrovascular accident (CVA) within 6 months prior to registration or that is not stable. Concomitant diseases/conditions: Unstable angina, myocardial infarction, valvular heart disease, encephalopathy, ischemic attacks, hemorrhagic or ischemic cerebrovascular accident (CVA) or ongoing pulmonary embolism within last year, arrhythmia, hepatopathy, uncontrolled infection, hemoptysis or oxygen requiring dyspnea, known HIV infection, bleeding risk, muscular problems, peripheral neuropathy, Symptomatic or progressive brain metastases or leptomeningeal disease. History of myocardial infarction or cerebrovascular accident within 6 months of enrollment date. Known history of cerebrovascular accident in the past 6 months. History of cerebral vascular accident (CVA) within 3 months prior to registration History of CVA within six months Subject has history of severe/unstable angina, myocardial infarction, or cerebrovascular accident within 6 months prior to the first dose of study drug. Severe cerebrovascular disease (multiple CVA or CVA within 6 months) Cerebrovascular accident (CVA) or stroke within the past 6 months Patients with history of acute myocardial infarction (MI) or cerebrovascular accident (CVA) within the last 12 months Patients with evidence/history of cardiac disease including congestive heart failure, symptomatic arrhythmia not controlled by medication, unstable angina or cardiac disease, history of acute myocardial infarction (MI) or cerebrovascular accident (CVA) within the past six months Patients with history of serious cardiac events defined as: \r\n* Patients with a history of New York Heart Association class 3 or 4 heart failure, or history of myocardial infarction, unstable angina or cerebrovascular accident (CVA) within 6 months of protocol registration \r\n* Patients who have history of PR prolongation (grade 2 or higher) or atrioventricular (AV) block Severe cerebrovascular disease (multiple CVA or CVA within 6 months) Myocardial infarction (MI); cerebrovascular accident (CVA); uncontrolled congestive heart failure (CHF); significant liver disease; or unstable angina within 6 months prior to enrollment Myocardial infarction (MI); cerebrovascular accident (CVA); uncontrolled congestive heart failure (CHF); or unstable angina within 6 months prior to enrollment Myocardial infarction (MI); cerebrovascular accident (CVA); uncontrolled congestive heart failure (CHF); significant liver disease; or unstable angina within 6 months prior to enrollment Myocardial infarction (MI); cerebrovascular accident (CVA); uncontrolled congestive heart failure (CHF); or unstable angina within 6 months prior to enrollment Had within 6 months prior to enrollment: myocardial infarction (MI), cerebrovascular accident (CVA), uncontrolled congestive heart failure (CHF), significant liver disease, unstable angina Severe uncontrolled cardiac disease within 6 months of study entry, including but not limited to uncontrolled hypertension; unstable angina; myocardial infarction (MI) or cerebrovascular accident (CVA). Myocardial infarction (MI); cerebrovascular accident (CVA); uncontrolled congestive heart failure (CHF); significant liver disease; or unstable angina within 6 months prior to enrollment