Known osteoblastic bony metastasis Subjects with brain metastasis Known brain metastasis Known parenchymal brain metastasis Known parenchymal brain metastasis Patients have known active brain metastasis Known brain metastasis Known bone metastasis Have a history of brain metastasis Known untreated brain metastasis or brain metastasis treated within 3 months prior to enrollment in this trial Patients with brain metastasis Subjects with brain metastasis Patients with known brain metastasis Known brain metastasis Patients with brain metastasis Patients have known active brain metastasis Known osteoblastic bony metastasis. Known brain metastasis History of or known brain metastasis. Known brain metastasis Known brain metastasis Known brain metastasis Known brain metastasis Known CNS disease, except for treated brain metastasis Participants may have brain metastasis Known brain metastasis Known brain metastasis. Known brain metastasis Brain metastasis Known parenchymal brain metastasis Patients with known brain metastasis Known brain metastasis Known brain metastasis Known brain metastasis or visceral organ metastasis Patients will be excluded if they have brain metastasis Brain metastasis Subjects with a history of brain metastasis. Known brain metastasis Known brain metastasis