No cardiac arrhythmias within 182 days of registration
History of any cardiac arrhythmias, e.g., ventricular, supraventricular, nodal arrhythmias, or conduction abnormality in the previous 12 months;
History of significant cardiac disease, cardiac risk factors, or uncontrolled arrhythmias
EXCLUSION CRITERIA FOR REGISTRATION: History of significant cardiac disease, cardiac risk factors, or uncontrolled arrhythmias
Ventricular arrhythmias requiring continuous therapy, or
Known cardiac arrhythmias requiring medication.
Adequate cardiac function with left ventricular ejection fraction >= 40%. No uncontrolled arrhythmias or symptomatic cardiac disease
Myocardial infarction in preceding 4 weeks; history of uncontrolled cardiac arrhythmias or family history of sudden cardiac death
Patients who have a history of significant cardiac disease, cardiac disease risk factors or uncontrolled arrhythmias are NOT eligible for either Stratum
No diagnosed arrhythmias
Symptomatic or uncontrolled arrhythmias
known uncontrolled arrhythmias (except sinus arrhythmia) in the past 24 weeks.
No uncontrolled arrhythmias or symptomatic cardiac disease
No uncontrolled arrhythmias or symptomatic cardiac disease
Uncontrolled arrhythmias
Research participant does not require pressor support and/or does not have symptomatic cardiac arrhythmias
Research participant requires pressor support and/or has symptomatic cardiac arrhythmias
Current, serious, clinically significant cardiac arrhythmias, defined as the existence of an absolute arrhythmia or ventricular arrhythmias classified as Lown III, IV or V (Appendix F).
Not requiring pressor support, not having symptomatic cardiac arrhythmias
(ELIGIBILITY CRITERIA AT TIME OF INFUSION OF GENETICALLY MODIFIED AUTOLOGOUS T CELLS): Not requiring pressor support, not having symptomatic cardiac arrhythmias
Not requiring pressor support, no symptomatic cardiac arrhythmias, no acute coronary syndrome, or uncontrolled hypertension
Cardiovascular: not requiring pressor support, no symptomatic cardiac arrhythmias, no acute coronary syndrome, or uncontrolled hypertension
Cardiovascular criteria: not requiring pressor support, no symptomatic cardiac arrhythmias, no acute coronary syndrome, or uncontrolled hypertension
Left ventricular ejection fraction >= 45%; no uncontrolled arrhythmias or uncontrolled symptomatic cardiac disease
Left ventricular ejection fraction >= 40%; no uncontrolled arrhythmias or uncontrolled symptomatic cardiac disease
current, serious, clinically significant cardiac arrhythmias as determined by the Investigator.
ENROLLMENT: Uncontrolled arrhythmias or uncontrolled symptoms of cardiac disease noted by screening history and physical. Patients with known cardiac dysfunction should have an ejection fraction (EF) > 40% documented by echocardiogram (ECHO).
Cardiac arrhythmias
History of significant cardiac disease, cardiac risk factors or uncontrolled arrhythmias
History of significant cardiac disease, cardiac risk factors or uncontrolled arrhythmias
Subjects with a known history of severe and/or uncontrolled ventricular arrhythmias.
Patients with a known history of severe and/or uncontrolled ventricular arrhythmias
No history of ventricular arrhythmias or severe cardiac dysfunction
No history of uncontrollable supraventricular arrhythmias
History of any cardiac arrhythmias, e.g., ventricular, supraventricular, nodal arrhythmias, or conduction abnormality within 12 months of screening
Serious cardiac illness or medical condition including but not confined to: Uncontrolled arrhythmias (e.g. ventricular tachycardia, high-grade atrioventricular (AV)-block, supraventricular arrhythmias which are not adequately rate-controlled);
Subjects with a known history of severe and/or uncontrolled ventricular arrhythmias.
Not requiring pressor support, not having symptomatic cardiac arrhythmias
History of any cardiac arrhythmias, e.g., ventricular, supraventricular, nodal arrhythmias, or conduction abnormality in the previous 12 months.
Subjects with a known history of severe and/or uncontrolled ventricular arrhythmias.
No currently unstable angina and/or uncontrolled cardiac arrhythmias
History of complex ventricular or supraventricular arrhythmias
Uncontrolled arrhythmias
Known history of severe and/or uncontrolled ventricular arrhythmias
Current, serious, clinically significant cardiac arrhythmias, defined as the existence of an absolute arrhythmia or ventricular arrhythmias classified as Lown III, IV or V.
No uncontrolled arrhythmias or symptomatic cardiac disease
History of or evidence of clinically significant uncontrolled cardiac arrhythmias
Recent malignant cardiac arrhythmias – all except sinus arrhythmia within 24 weeks prior to screening
Known significant uncontrolled cardiac arrhythmias
Known, uncontrolled cardiac arrhythmias (except sinus arrhythmia) within the past 24 weeks
Adequate cardiac function with left ventricular ejection fraction at least 45% on appropriate medical therapy; no uncontrolled arrhythmias or symptomatic cardiac disease
History of significant cardiac disease, cardiac risk factors or uncontrolled arrhythmias
Patients with currently uncontrolled cardiac arrhythmias (non-sinus rhythm) will be excluded; patients with history of arrhythmias under pharmacological/pacemaker control will be allowed, except if receiving antiarrhythmic medication listed in “contra-indicated medications” below
Uncontrolled arrhythmias
Uncontrolled arrhythmias causing symptoms or hemodynamic compromise in the last week
Known cardiac disorders including arrhythmias, hypertension requiring treatment or structural heart disease
History of cardiac arrhythmias
EXCLUSION CRITERIA (PRIOR TO IBRUTINIB ADMINISTRATION): Uncontrolled cardiac arrhythmias
Serious ventricular arrhythmias or high risk for arrhythmias, due to prolongation of the QT-interval (> 60 milliseconds [msec])
History of significant cardiac disease or uncontrolled arrhythmias