Renal insufficiency as indicated by a creatinine level >3 times ULN Adequate renal function, as indicated by creatinine =< 1.5 x ULN Adequate renal function, as indicated by creatinine =< 1.5 x the upper limit of normal (ULN) Patients are required to have adequate renal function as indicated by a serum creatinine =< 2.5 mg/dL; this value must be obtained within four weeks before protocol entry Renal insufficiency as indicated by a creatinine level > 2 x the ULN. Inadequate renal function as indicated by serum creatinine >= 1.5 times the upper limit of normal Adequate renal function, as indicated by creatinine =< 1.5 x upper limit of normal (ULN) Adequate renal and liver function as indicated by: