History of adrenal insufficiency or hypoaldosteronism
No uncontrolled adrenal insufficiency
Immunosuppressive steroids within 3 months before first ZW25 dosing, except for chronic steroid doses of ?15 mg per day for adrenal insufficiency
Patients with known adrenal insufficiency, or patients receiving treatment with ketoconazole, abiraterone, or aminoglutethimide.
Systemic corticosteroid therapy at doses of greater than 5 mg daily for therapeutic and not adrenal replacement indications (maintenance steroid use for adrenal insufficiency is permitted)
Uncontrolled adrenal insufficiency or active chronic liver disease
Uncontrolled adrenal insufficiency
Uncontrolled adrenal insufficiency
Uncontrolled adrenal insufficiency
Uncontrolled adrenal insufficiency or active chronic liver disease
Immunosuppressive therapy including systemic corticosteroids except for maintenance dosing for adrenal insufficiency
Uncontrolled adrenal insufficiency.
Uncontrolled adrenal insufficiency or active chronic liver disease
Use of systemic corticosteroid therapy (except for replacement doses of glucocorticoid and/or mineralocorticoid for adrenal insufficiency); inhaled or intranasal corticosteroids for allergic or bronchospastic conditions are permitted
Patients with a known history of primary and secondary adrenal insufficiency are not eligible
History of adrenal insufficiency (including subjects using replacement therapy)
Patients with adrenal insufficiency or patients currently requiring chronic, systemic corticosteroid therapy at any dose for longer than 2 weeks. Local steroid therapies (eg, otic, ophthalmic, intraarticular, or inhaled medications) are acceptable
History of adrenal insufficiency
Uncontrolled adrenal insufficiency
ADRENAL GLAND:
Unilateral adrenal disease
Any steroid treatment except for that required for replacement therapy in adrenal insufficiency or inhaled steroids for the treatment of asthma
History of adrenal insufficiency
Nonfunctioning adrenal neoplasm
Arterial insufficiency
Known diagnoses of diabetes mellitus, adrenal insufficiency (Addison’s disease), or Cushing’s syndrome
Uncontrolled adrenal insufficiency
Immunosuppressive therapy including systemic corticosteroids except for maintenance dosing for adrenal insufficiency