Histologically proven adenocarcinoma of the prostate Prostate cancer proven by histopathology Histologically-proven prostate adenocarcinoma\r\n* Gleason score 6-10 based on a review of the prostate core biopsies at Moffitt Cancer Center Biopsy proven prostate cancer Histologically proven adenocarcinoma of the prostate diagnosed (with ?10 core biopsy) within 6 months of screening. The biopsy that was used for this diagnosis must be submitted for central pathology review. Histologically proven prostate adenocarcinoma:\r\n* Gleason score 2-7 \r\n* Biopsy within one year of date of registration Patients with histopathologically proven adenocarcinoma of the prostate Have biopsy proven carcinoma of the prostate Histologically proven adenocarcinoma of the prostate Histologically proven adenocarcinoma of the prostate Histologically or cytologically proven diagnosis of prostate cancer. Histologically proven adenocarcinoma of the prostate Histologically or cytologically proven prostate carcinoma Histologically proven adenocarcinoma of the prostate Histologically proven adenocarcinoma of the prostate Histologically or cytologically proven adenocarcinoma of the prostate; if pathology is unavailable, the principal investigator (PI) may also make a determination of prostate cancer based on unequivocal clinic data Patient must have non-metastatic, biopsy proven prostate cancer Patient had a prostate biopsy performed by Dr. Mark with the Artemis device and has adenocarcinoma of the prostate Biopsy proven adenocarcinoma of the prostate (using a IMAGE-guided 14+ core mapping biopsy), and targeted cores as needed obtained up to 6 months prior to scheduled treatment. COHORT I: Biopsy proven adenocarcinoma of the prostate Histopathology proven prostate cancer. Histopathologically proven prostate cancer (PCa) Histopathological proven prostate adenocarcinoma Pathologically proven prostate adenocarcinoma Biopsy-proven prostate adenocarcinoma Biopsy proven prostate adenocarcinoma Histopathologically proven prostate adenocarcinoma SUB-STUDY I: Newly diagnosed prostate cancer pathologically proven by prostate biopsy SUB-STUDY II: Prostate cancer pathologically proven by prostate biopsy SUB-STUDY III: Prostate cancer pathologically proven by prostate biopsy Biopsy proven prostate adenocarcinoma Histopathological proven prostate adenocarcinoma Biopsy proven prostate adenocarcinoma Biopsy-proven prostate cancer Not otherwise eligible for prostate biopsy Have biopsy proven carcinoma of the prostate Biopsy proven prostate adenocarcinoma Biopsy proven prostate adenocarcinoma Biopsy proven adenocarcinoma of the prostate At least 4 weeks after most recent prostate biopsy Males with known (biopsy?confirmed) primary adenocarcinoma of the prostate undergoing active surveillance scheduled for prostate biopsy (population group B) Biopsy proven, clinical stage 1-3 prostate carcinomas Patients who had > 1 prior prostate biopsy Biopsy proven prostate adenocarcinoma Histopathological proven prostate adenocarcinoma Prostate adenocarcinoma diagnosed by biopsy within 12 months prior to study registration Prior prostate biopsy