Alkaline phosphate =< 3 x normal Alkaline phosphatase within upper limits of institutional normal within 14 days prior to study entry Alkaline phosphatase =< 2.5 x institutional upper limit of normal Alkaline phosphatase < 2.5 x upper limit of normal if no documented liver disease or < 6 x upper limit of normal if documented liver or bone disease Alkaline phosphatase =< 5 x upper limit of normal Alkaline phosphatase =< 2.5 X institutional upper limit of normal, determined within 14 days of registration Alkaline phosphatase =< 5 x upper limit normal (ULN) PART I: Alkaline phosphatase (Alk PO4) =< 3 x the upper limits of normal (except for patients with documented metastatic disease to bone and/or liver) Bilirubin <= 1.5 mg/dL; ALT, AST, and alkaline phosphatase <= 3.0x the upper limit of normal Alkaline phosphatase =< 2 x upper limit of normal Alkaline phosphatase =< 2.5 x upper limit of reference range (or =< 5 x upper limit of reference range if considered to be related to liver or bone metastases by the principal investigator [PI]) Alkaline phosphatase < 3 x institutional upper limit of normal (ULN) Alkaline phosphatase >= 3 x institutional upper limit of normal (ULN) Alkaline phosphatase =< 3 x upper limit of normal Alkaline phosphatase =< 2.5 x institutional upper limit of normal Alkaline phosphatase =< 3 X the upper limit of normal (ULN) Alkaline phosphatase =< 3 x institutional upper limit of normal within 30 days of registration Alkaline phosphatase < 5 x upper limit of normal Bilirubin >2.0; alkaline phosphatase >5x upper limit of normal (ULN); ALT/AST >2x ULN. Alkaline phosphatase =< 2.5 institutional upper limit of normal of =< 5 x ULN if liver metastases are present Alkaline phosphatase =< 2.5 x normal prior to biopsy Alkaline phosphatase > 5 X upper limits of normal (ULN) Alkaline phosphatase levels =< 2.5 x upper limit of normal (ULN) Alkaline phosphatase =< 2.5 x upper limit (UL) Alkaline phosphatase < 5 x upper limit of normal (ULN) Alkaline phosphatase =< 2 x upper limit of normal, unless proven to be due to disease involvement ADDITIONAL CRITERIA FOR STUDY CONTINUATION: Alkaline phosphatase (alk phos) =< 5 X upper level of normal Alkaline phosphatase < 2.5 x upper limit of normal Alkaline phosphatase < 3 x upper limit of normal (ULN) Alkaline phosphatase < 2 x upper limit of normal Alkaline phosphatase < 2 upper limit of normal (ULN) Alkaline phosphatase less than 1.5 x upper limit of normal Alkaline (Alk) phosphatase (Phos) =< 5 x upper limit of normal Alkaline phosphatase must be =< 4 x the institutional upper limit of normal (ULN) Alkaline phosphatase =< 5 x the upper limit of normal; serum bilirubin > 2.0 is acceptable in the setting of known Gilbert’s syndrome Bilirubin, aspartate aminotransferase (AST), alkaline phosphatase (ALK) =< 2 x normal Aspartate aminotransferase (AST) and alkaline phosphatase < 5 x upper limit of normal AST and alkaline phosphatase < 5 x upper limit of normal Alkaline phosphatase level =< upper limit of normal (ULN) Alkaline phosphatase (ALK Phos) =< 2.5 X institutional upper limit of normal Alkaline phosphatase =< 4 x institutional upper limit of normal (IULN) Alkaline (Alk) phosphatase =< 5 x upper limit of normal Alkaline phosphatase > 3 x normal Within 14 days of registration: Alkaline phosphatase =< 5 x upper limit of normal Alkaline phosphatase =< 2.5 x institutional upper limit of normal Alkaline phosphatase =< 3 X institutional upper limit of normal Alkaline phosphatase =< 3 X institutional upper limit of normal No history of severe prior or ongoing chronic liver disease; alkaline phosphatase < 5 x upper limit of normal Alkaline phosphatase =< 2.5 x upper limit of normal Alkaline phosphatase =< 3 x institutional normal Alkaline phosphatase =< 5 X upper limit of normal (ULN) Alkaline phosphatase < 2 x upper limit of normal, or considered not clinically significant by the study doctor or designee Alkaline phosphatase < 5 x upper limit normal (ULN) Within 14 days of registration: Alkaline phosphatase =< 2.5 × institutional upper limit of normal Alkaline phosphatase =< 3 X the upper limit of normal (ULN) Alkaline phosphates must be =< 2.5 X the upper limit of normal Alkaline phosphatase (AP) =< 3 x institutional upper limit of normal Alkaline phosphatase =< 2.5 x upper limit of normal (ULN) Alkaline phosphatase =< 2.5 x institutional upper limit normal Alkaline phosphatase =< 2.5 x normal prior to biopsy Alkaline phosphatase ? 2.5 x upper limit of normal (ULN) Alkaline phosphatase =< 2.5 x normal limits Alkaline phosphatase =< upper limit of normal (ULN) and AST or ALT =< ULN eligible Alkaline phosphatase less than or equal to 2.5 x upper limit of normal, CTCAE v 4.0 grade 1 Alkaline phosphatase =< 2.5 x upper limit of normal (ULN) Alkaline phosphatase =< 2.5 X upper limit of normal Alkaline phosphatase =< 1.5 x upper limit of normal Alkaline phosphatase =< 2.5 x upper limit of normal (ULN) Alkaline phosphatase =< 2 x upper limit of normal Alkaline phosphatase > 2 x upper limits of normal (ULN) Alkaline phosphatase =< 2.5 X upper limit of normal Alkaline phosphatase < 2 X upper limit of normal Alkaline phosphatase =< 2.5 x upper limit of normal (ULN) Alkaline phosphatase < 3 x upper limit of normal Alkaline phosphatase < 2.5 X institutional upper limit of normal Alkaline phosphatase =< 5x upper limit of normal Alkaline phosphatase =< 1.5 x upper limit of normal (ULN). Obtained =< 30 days prior to registration: Alkaline phosphatase =< 3 x the institutional upper limit of normal Alkaline phosphatase =< 2.5 x the upper normal limit Alkaline phosphatase =< 2.5 X upper limit of normal; in patients with bone metastasis and no evidence of liver metastasis and bilirubin =< upper limit of normal an alkaline phosphatase =< 5 ULN will be allowed Alkaline phosphatase =< 2.5 x upper limit of normal Alkaline phosphatase < 5 x upper limit of normal Alkaline phosphatase =< 1.5 x institutional upper limit of normal (ULN) Alkaline phosphatase (ALK) =< 1.5 x upper limit of normal (ULN) Liver alkaline phosphatase =< 3 x upper limit of normal Alkaline phosphatase < 2.5 x the upper limit of normal Alkaline phosphatase =< 1.5 x upper limit of institutional normal Alkaline phosphatase =< 1.5 x institutional upper limit of normal Alkaline phosphatase must be less than 4 x upper limit of normal Alkaline phosphatase =< 2.5 x upper limits of normal if no liver metastases present; alkaline phosphatase =< 5 x upper limits of normal if liver metastases present Alkaline phosphatase within normal limits Alkaline phosphatase (Alk phos) =< 2.5 X institutional upper limit of normal