Patients with active implanted devices, such as pacemakers, defibrillators, and drug infusion pumps
Implanted pacemaker, defibrillator, deep brain stimulator, or other implanted electronic devices in the brain or other documented clinically significant arrhythmias
Implantable electronic medical devices in the brain
Patients with active implanted medical device, a skull defect (such as, missing bone with no replacement), a shunt or bullet fragments; examples of active electronic devices include deep brain stimulators, spinal cord stimulators, vagus nerve stimulators, pacemakers, defibrillators, and programmable shunts
Contraindication to MR imaging, such as implanted metal devices or foreign bodies or severe claustrophobia
Have implanted cardiac pacemakers or defibrillators
Have implanted electronic devices or implants with metal parts in the immediate vicinity of a lesion
Implanted pacemaker, defibrillator or deep brain stimulator, other implanted electronic devices in the brain or documented clinically significant arrhythmias
Implantable electronic device in the brain
Implanted pacemaker, programmable shunts, defibrillator, deep brain stimulator, other implanted electronic devices in the brain, or documented clinically significant arrhythmias
Implanted pacemaker, defibrillator or deep brain stimulator, or documented clinically significant arrhythmias
Has implanted medical device(s) that pose a high risk for colonization and/or cannot be easily removed (e.g., prosthetic joints, artificial heart valves, pacemakers, orthopedic screw(s), metal plate(s), bone graft(s), or other exogenous implant(s)).
Has implanted pacemaker, programmable shunts, defibrillator, deep brain stimulator, other implanted electronic devices in the brain
Implanted with heart pacemaker or other implanted electronic device
Contraindications to MR imaging (e.g. implanted metallic prostheses, defibrillators, stimulators, pacemakers, or neurotransmitters) per institutional policy on management of patients with internal and external medical devices.
Implanted pacemaker, programmable shunts, defibrillator, deep brain stimulator, vagus nerve stimulator, and other implanted electronic devices in the brain or the spinal cord.
Patients with a contraindication to MRI such as implanted metal devices or foreign bodies or severe claustrophobia
Implanted hardware which limits treatment planning or delivery (determined by the investigator)
Patients with electronic pacemakers or defibrillators.
The patient has implanted medical device(s) that pose a high risk for colonization and/or cannot be easily removed (e.g., prosthetic joints, artificial heart valves, pacemakers, orthopedic screw(s), metal plate(s), bone graft(s), or other exogenous implant[s]); NOTE: More common devices and prosthetics which include arterial and venous stents, dental and breast implants and venous access devices (e.g. Port-a-Cath or Mediport) are permitted; the study chair must be contacted prior to consenting any subject who has any other device and/or implant
Patients with active implanted medical or electronic device or bullet fragments including pacemakers, defibrillators, deep brain stimulators, spinal cord stimulators, vagus nerve stimulators, and programmable shunts
Patients with active implanted electronic devices in the brain or spinal cord such as programmable VP shunts, deep brain stimulators, vagus nerve stimulators, are not allowed
Any contraindication to MRI (i.e. patients with pacemakers or other metal implanted medical devices)
Prior history of hip, pelvic, or lumbosacral prosthesis or other implanted device
Pacemakers or other implanted cardiac rhythm management/monitoring devices and non-MR conditional heart valves
Patients with standard contraindications for MR imaging such as non-MRI compatible implanted metallic devices including cardiac pacemakers, size limitations, etc.
Fewer than two acceptable sites exist for intramuscular (IM) injection and electroporation (EP) between the deltoid and lateral quadriceps muscles. Note: a site for injection/EP is not acceptable if there are tattoos or scars within 2 cm of the proposed injection/EP site or if there is implanted metal within the same limb. Any device implanted in the chest (e.g. cardiac pacemaker or defibrillator) excludes the use of the deltoid muscle on the same side of the body.
Has implanted medical device(s) that pose a high risk for colonization and/or cannot be easily removed (e.g., prosthetic joints, artificial heart valves, pacemakers, orthopedic screw(s), metal plate(s), bone graft(s), or other exogenous implant(s)). NOTE: More common devices and prosthetics which include arterial and venous stents, dental and breast implants, and venous access devices (e.g., Port-a-Cath or Mediport) are permitted. Sponsor must be contacted prior to consenting any subject who has any other device and/or implant
The subject has an implanted pacemaker, programmable shunts, defibrillator, deep brain stimulator, other implanted electronic devices in the brain, or documented clinically significant arrhythmias
Has implanted medical devices that pose high risks for colonization and cannot be easily removed
Subjects who have implanted medical devices that pose high risks for colonization and cannot be easily removed (e.g. artificial heart valves, pacemakers, prosthetic joints, orthopedic screw(s), metal plate(s)) if infection occurs. Other common devices such as venous access devices (e.g. Port-a-Cath or Mediport) may be permitted as well as arterial and venous stents and dental and breast implants that were placed more than 3 months prior to first dose of study drug.
Implanted medical devices that pose high risks for colonization and cannot be easily removed (e.g., artificial heart valves, pacemakers, prosthetic joints, orthopedic screw(s), metal plate(s)) if infection occurs. Other common devices such as venous access devices (e.g., Port-a-Cath or Mediport) may be permitted as well as arterial and venous stents and dental and breast implants that were placed more than 3 months prior to first dose of study drug.
Has implanted medical device(s) that pose a high risk for colonization and/or cannot be easily removed (e.g., prosthetic joints, artificial heart valves, pacemakers, orthopedic screw(s), metal plate(s), bone graft(s), or other exogenous implant(s)). NOTE: More common devices and prosthetics which include arterial and venous stents, dental and breast implants, and venous access devices (e.g., Port-a-Cath or Mediport) are permitted. Sponsor must be contacted prior to consenting any subject who has any other device and/or implant.
Implanted device or apparatus which obstruct visibility of the implanted sources on fluoroscopy
Patients with electronic pacemakers or defibrillators are excluded from this study, as the effect of electroporation on these devices is unknown; patients with lower extremity lesions may be discussed with the medical monitor
Has implanted medical device(s) that pose a high risk for colonization and/or cannot be easily removed (e.g., prosthetic joints, artificial heart valves, pacemakers, orthopedic screw(s), metal plate(s), bone graft(s), or other exogenous implant(s)). NOTE: More common devices and prosthetics which include arterial and venous stents, dental and breast implants, and venous access devices (e.g., Port-a-Cath or Mediport) are permitted. Sponsor must be contacted prior to consenting any subject who has any other device and/or implant.
Subjects who have implanted medical devices that pose high risks for colonization and cannot be easily removed (e.g., artificial heart valves, pacemakers, prosthetic joints, orthopedic screw(s), metal plate(s)) if infection occurs; other common devices such as venous access devices (e.g., Port-a-Cath or Mediport) may be permitted as well as arterial and venous stents and dental and breast implants
Has implanted medical device(s) that pose a high risk for colonization and/or cannot be easily removed (e.g., prosthetic joints, artificial heart valves, pacemakers, orthopedic screw(s), metal plate(s), bone graft(s), or other exogenous implant(s)). NOTE: More common devices and prosthetics which include arterial and venous stents, dental and breast implants, and venous access devices (e.g., Port-a-Cath or Mediport) are permitted. Sponsor must be contacted prior to consenting any subject who has any other device and/or implant.
Implanted medical device such as a pacemaker, defibrillator, deep brain stimulator, or vagus nerve stimulator, or documented significant arrhythmia at the discretion of the investigator
Patients with Gliadel bis-chloroethylnitrosourea (BCNU) implanted wafers will be excluded
Patient has implanted medical device(s) that pose a high risk for colonization and/or cannot be easily removed (e.g., prosthetic joints, artificial heart valves, pacemakers, orthopedic screw(s), metal plate(s), bone graft(s), or other exogenous implant(s)); NOTE: more common devices and prosthetics which include arterial and venous stents, dental and breast implants and venous access devices (e.g., Port-a-Cath or Mediport) are permitted; sponsor must be contacted prior to consenting any subject who has any other device and/or implant
Implanted pacemaker, defibrillator or deep brain stimulator, or documented clinically significant arrhythmias
Active implanted medical device (e.g. deep brain stimulators, spinal cord stimulators, vagus nerve stimulators, pacemakers, defibrillators, and programmable shunts)
Patients with electronic pacemakers or defibrillators are excluded.
Subject has been implanted with a previous neuromodulation system (PNfS, SCS-PNfS or SCS) or participated in a trial for a neuromodulation system
Patients with contraindication for MR imaging such as implanted metallic devices that are not MRI-safe, size limitations, etc.
Implanted electronic medical device in the brain:
Active implanted medical device (e.g. deep brain stimulators, spinal cord stimulators, vagus nerve stimulators, pacemakers, defibrillators, and programmable shunts), a skull defect (such as missing bone with no replacement), a shunt, or bullet fragments
Tattoos or scars within 2 cm of the intended site of injection or if there is implanted metal within the same limb. Any device implanted in the chest (e.g., cardiac pacemaker or defibrillator) excludes the use of the deltoid muscle on the same side of the body;
Prior liver or heart transplantation or implanted cardiac mechanical assist device.
Implanted pacemaker, programmable shunts, defibrillator, deep brain stimulator, vagus nerve stimulator, and other implanted electronic devices in the brain or the spinal cord
MRI ineligibility due to the presence of a cardiac pacemaker, defibrillator or other implanted metallic or electronic device which is considered MR unsafe, severe claustrophobia or inability to lie flat for the duration of the study, etc.
Patients with electronic pacemakers or defibrillators are excluded from this study
Use of venous access devices made of materials other than silicone for the infusion of ganetespib; patients with these devices are eligible as long as the device is not used for the infusion
Have any active implanted electronic device (e.g., pacemaker),
Have an implanted electronically charged medical device
Patients with standard contraindications for MR imaging such as non-MRI compatible implanted metallic devices including cardiac pacemakers, size limitations, etc.
implanted devices that cannot be easily removed
Implanted pacemaker, defibrillator or deep brain stimulator, other implanted electronic devices in the brain.
Cardiac pacemaker or other implanted electronic devices
As per self-report participants with pacemakers, intracranial electrodes, implanted defibrillators or any other prosthesis
Patients with only totally implanted CVCs or ports are ineligible
Existing implantable medical electronic devices, life-supporting medical devices, and medical monitoring devices \r\n* Note: metal implants for orthopedic repair, e.g. pins, clips, plates, cages, joint replacements are allowed as are central venous access devices
No implanted medical devices or implanted metal in the head
Pacemaker or other electronic implanted device
Patients with cardiac pacemakers or other implanted electronic devices
Have an implanted device for heart failure (e.g., pacemaker, defibrillator, left ventricular assist device, etc.)
Has an implanted electronically charged medical device
Pacemaker or other implanted device
Active implanted medical device (e.g., cardiac pacemakers, defibrillators) or patients connected to electronic life support devices or metallic devices that would interfere with BIS measurements.
Have a pacemaker or implanted device.
No contraindications to the performance of a magnetic resonance study:\r\n* The presence of an implanted metallic object such as a cardiac pacemaker or implantable\r\ndefibrillator\r\n* An implanted neural stimulator\r\n* Any ferromagnetic implants not deemed MRI-safe\r\n* Intra-ocular metallic foreign bodies\r\n* Severe claustrophobia\r\n* Pregnancy\r\n* Inability to perform an exercise test
No implanted metallic objects
The presence of an implanted pacemaker or implanted defibrillator device
Implanted medical device not described above that is not MRI-compatible
Presence of an implanted device that is incompatible with CT scanning
Active implanted devices, such as pacemakers, defibrillators, and drug infusion pumps
The presence of an implanted pacemaker or implanted defibrillator device
Implanted medical device not described above that is not MRI-compatible
Patients with pacemakers or other implanted magnetic devices that may malfunction or move in the strong magnetic field
Intracranial metal, pacemakers, defibrillators, functioning neurostimulator devices, or other implanted electronic devices
Subjects with any type of bioimplant activated by mechanical, electronic, or magnetic means (e.g., cochlear implants, pacemakers, neurostimulators, biostimulators, electronic infusion pumps, etc.)
The presence of an implanted pacemaker or implanted defibrillator device
Implanted medical device not described above that is not MRI-compatible
have implanted prosthetic heart valve,
Subjects who have vascular access ports or other implanted devices rated as anything other than “safe” or “conditional 6”
MRI-incompatible metallic implants, embedded metallic objects, implanted biomedical devices e.g., cardiac pacemakers
Participants with an implanted device, prosthesis, or any other foreign body with ferromagnetic properties that would make them ineligible to undergo MRI examination
Subjects with a counter-indication to MRI, such as the presence of metallic prostheses or implanted metal device (e.g., infusion pump, defibrillator)
Patients who have any type of bioimplant activated by mechanical, electronic, or magnetic means (e.g., cochlear implants, pacemakers, neurostimulators, biostimulators, electronic infusion pumps, etc), because such devices may be displaced or malfunction
Subjects who have any type of bioimplant activated by mechanical, electronic, or magnetic means (e.g., cochlear implants, pacemakers, neurostimulators, biostimulators, electronic infusion pumps, etc.), because such devices may be displaced or malfunction
Subjects who have vascular access ports or other implanted devices rated as anything other than “Safe” or “Conditional 6”
Patients with active implanted devices, such as pacemakers, defibrillators, and drug infusion pumps since the effect of the Calypso System operation on these devices is unknown.
Current use of any implanted electronic stimulation device