Known or suspected allergy or hypersensitivity to the study drug Known prior or suspected hypersensitivity to investigational products Patients with known hypersensitivity to perflutren Known hypersensitivity to study drug and/or drug class Has a known hypersensitivity to any of the study therapy products Known hypersensitivity to any study drug used in this trial Known hypersensitivity to any study drug Known or suspected hypersensitivity to ruxolitinib. Known hypersensitivity to any study drug Known hypersensitivity to any component of the investigational products; known hypersensitivity to salicylates; known hypersensitivity to aspartame-containing products for patients with phenylketonuria; known allergies to any of the medications or components of medications used in the trial Known hypersensitivity to any study drug Known hypersensitivity to acyclovir or similar anti-viral drug Has a known hypersensitivity to any of the study therapy products Known hypersensitivity to trial drug Known hypersensitivity to acyclovir or similar anti-viral drug Known prior or suspected hypersensitivity to investigational products. Hypersensitivity to acyclovir or similar anti-viral drug Known hypersensitivity to any study drug Patients with known or suspected hypersensitivity to perflutren History of hypersensitivity to Definity (perflutren lipid microsphere) or Lumason Known hypersensitivity to sulfur hexafluoride or to any component of perflutren lipid (Definity) Known hypersensitivity to any component of perflutren lipid (Definity) Hypersensitivity to perflutren Known hypersensitivity to perflutren (if the patient has been exposed to perflutren in the past and had an allergic reaction) Women with known cardiac shunt, pulmonary hypertension or hypersensitivity to perflutren agent Patients with known or suspected hypersensitivity to perflutren Patients with any known hypersensitivity to perflutren agent Patients with known hypersensitivity to perflutren Patients with known hypersensitivity to perflutren Known or suspected: hypersensitivity to perflutren, blood, blood products or albumin Known or suspected: hypersensitivity to a prior perflutren protein-type A microspheres (OPTISON) administration