Major surgery, other than diagnostic surgery, within 4 weeks prior to Cycle 1 Day 1, without complete recovery. Major surgery, other than diagnostic surgery, within 2 weeks prior to Cycle 1 Day 1, without complete recovery. Major surgery, other than diagnostic surgery, within 2 weeks prior to Cycle 1 Day 1, without complete recovery. Participant had major surgery within 28 days prior to Study Day 1. Reasonably recovered from preceding major surgery as judged by the investigator or no major surgery within 4 weeks prior to the start of Day 1 treatment Patients who underwent major surgery within 4 weeks before the planned day for the first treatment Major surgery within 2 months prior to enrollment or minor surgery within 7 days of the first day of treatment Major surgery, other than diagnostic surgery, within 2 weeks prior to Cycle 1 Day 1, without complete recovery. Subject has had major surgery within 28 days prior to study day 1 Major surgery within 28 days of study day 1 with the exception of biopsy and long line insertion Reasonably recovered from preceding major surgery as judged by the investigator or no major surgery within 4 weeks prior to the start of Day 1 treatment Patient has undergone major surgery, other than diagnostic surgery (ie, surgery done to obtain a biopsy for diagnosis without removal of an organ), within 4 weeks prior to Day 1 of treatment in this study. Major surgery must have been completed ? 4 weeks prior to starting treatment day 1; patient must be sufficiently recovered and stable from surgery prior to treatment day 1 Patients must have recovered from the effects of surgery per treating physician’s judgment; there must be a minimum of 21 days from the day of surgery to the day of protocol treatment; for core or needle biopsy, a minimum of 14 days must have elapsed prior to the day of protocol treatment Major surgery within 6 weeks prior to study day 1 (subjects must have completely recovered from any previous surgery prior to study day 1) Major surgery within 4 weeks prior to enrollment (day 1) Patients must have recovered from the effects of surgery; there must be a minimum of 21 days from the day of surgery to the day of protocol treatment Major surgery within 28 days prior to day 1 of study treatment from which the patient has not completely recovered Major surgery within 2 weeks before day 1. Major surgery other than diagnostic surgery within 28 days of Study Day 1 Any major surgery within 4 weeks or a diagnostic procedure (eg incision, needle biopsy) within 1 day of study drug administration Major surgery within 4 weeks prior to day 1 of the study or who have not recovered from prior surgery Major surgery, other than diagnostic surgery, within 4 weeks prior to day 1, without complete recovery from the surgical procedure Reasonably recovered from preceding major surgery as judged by the Investigator or no major surgery within 4 weeks prior to the start of Day 1 treatment Major surgery within 6 weeks prior to study day 1 (subjects must have completely recovered from any previous surgery prior to study day 1); biopsy, diagnostic tonsillectomy, airway tumor debulking or excisional lymph node biopsy do not constitute major surgery Major surgery other than diagnostic surgery within 28 days of Study Day 1 Subject has had major surgery within 28 days prior to study day 1 Major surgery requiring a prolonged hospitalization or recovery within 21 days before day 1 of study drug Major surgery within four weeks before day 1 Patients must have recovered from the effects of surgery; there must be a minimum of 21 days from the day of surgery to the day of protocol treatment; for core or needle biopsy, a minimum of 7 days must have elapsed prior to the day of protocol treatment Major surgery within 4 weeks prior to day 1 Major surgery, other than diagnostic surgery, within 4 weeks prior to Day 1, without complete recovery Have major surgery, other than diagnostic surgery, within 4-weeks prior to Day 1 Systemic radiation therapy or major surgery < 28 days prior to study Day 1 as well as focal radiotherapy < 14 days prior to study Day 1. Major surgery (as defined by the investigator) within the 28 days prior to day 1 of protocol therapy Major surgery within 4 weeks prior to day 1 of the study or who have not recovered from prior surgery Major surgery within 2 weeks before day 1 Major surgery within four weeks before day 1 Major surgery within 6 weeks prior to study day 1 (subjects must have completely recovered from any previous surgery prior to study day 1) Major surgery within 4 weeks prior to study day 1 (patients must have recovered completely from any previous surgery prior to study day 1). Subject had a major surgery within 4 weeks prior to day 1. Major surgery within 4 weeks prior to Day 1 study Subject has undergone major surgery, other than diagnostic surgery (i.e. surgery done to obtain a biopsy for diagnosis or an aborted Whipple), within 28 days prior to day 1 of treatment in this study Have received prior chemotherapy, other investigational therapy, or major surgery within 4 weeks of Day 1; Subject has undergone major surgery, other than diagnostic surgery (i.e.--surgery done to obtain a biopsy for diagnosis or an aborted Whipple), within 28 days prior to day 1 of treatment in this study Any major surgery within 4 weeks or a diagnostic procedure (e.g. incision, needle biopsy) within 1 day of study drug administration Major surgery within 4 weeks prior to Day 1 of study or who have not recovered from prior surgery Major surgery within 28 days of study day 1 Major surgery within 4 weeks prior to enrollment (day 1 visit) Subjects who had major surgery within 4 weeks of the first day of study drug. Major surgery within 6 weeks prior to study day 1 (subjects must have completely recovered from any previous surgery prior to study day 1) Major surgery within four weeks before day -7 Major surgery within 21 days prior to the first day of treatment Major surgery within 2 weeks before day 1 Major surgery within 4 weeks or minor surgery within 7 days of the first day of study drug dosing Major surgery < 4 weeks or minor surgery (e.g. talc pleurodesis, excisional biopsy, etc) < 2 weeks prior to the first day of study defined treatment Major surgery within 4 weeks prior to enrollment (day 1 visit) Major surgery within 4 weeks before first day of study drug dosing Major surgery or radiation therapy within 4 weeks of enrollment (day 1 visit) Major surgery within 4 weeks of Study Day 1 Major surgery within 3 weeks prior to day 1 of study treatment from which the patient has not completely recovered Patient has undergone a major surgery, other than diagnostic surgery (i.e. surgery done to obtain a biopsy for diagnosis without removal of an organ) within four weeks prior to day 1 of treatment on this study Major surgery within 28 days of Day 1 Major surgery within 4 weeks prior to day 1 of the study or who have not recovered from prior surgery Major surgery within three months prior to Day 1 of study or who have not recovered adequately from prior surgery. Has had major surgery (requiring at least a 3 day hospital stay) in the past 28 days Major surgery within 4 weeks prior to Day 1 visit. Major surgery within 28 days of study day 1 Subject has undergone major surgery for any reason, other than diagnostic surgery (ie, surgery done to obtain a biopsy for diagnosis without removal of an organ), within 4 weeks prior to Cycle 1 Day 1 of treatment in this study. Major surgery within 4 weeks prior to day 1 of the study or who have not recovered from prior surgery Major surgery, other than diagnostic surgery, within 4 weeks prior to Cycle 1 Day 1, without complete recovery Patients that have had major surgery =< 3 weeks or minor surgery (e.g. talc pleurodesis, excisional biopsy, etc) =< 1 week prior to the first day of study defined treatment At the time of day 1 of the study, patients must be at least 3 weeks since surgery. Patient has undergone major surgery, other than diagnostic surgery (i.e.--surgery done to obtain a biopsy for diagnosis without removal of an organ), within 4 weeks prior to day 1 of treatment in this study Patient has undergone major surgery, other than diagnostic surgery (i.e. surgery done to obtain a biopsy for diagnosis without removal of an organ), within 4 weeks prior to day 1 of treatment in this study Major surgery within 4 weeks prior to day 1 Major surgery within 14 days before day 1. Major surgery, chemotherapy, investigational agent, or radiation within 30 days of Day Major surgery within 28 days of study day 1 Major surgery within 3 weeks before day 1 Major surgery within 2 weeks before day 1 Major surgery within 21 days before Study Day 1; Be reasonably recovered from preceding major surgery as judged by the investigator or no major surgery within 4 weeks prior to the start of day 1 treatment Anti-tumor therapy of any kind or major surgery within 4 weeks prior to Day 1. Any major surgery within 4 weeks prior to day 1 Major surgery, chemotherapy, investigational agent, or radiation within 30 days of Day 1 Major surgery within 30 days of study day 1 Major surgery, radiotherapy, chemotherapy or investigational agents within four weeks of treatment day 1 Have reasonably recovered from preceding major surgery as judged by the investigator or have had no major surgery within 4 weeks prior to Day 1 treatment. Have had major surgery within 30 days prior to the start of Day 1; Use of dexmedetomidine within 28 days prior to day of surgery Major surgery within 30 days of day 1 of trial