INCLUSION CRITERIA FOR SECOND-LINE THERAPY: Patients may have a transfusion of red blood cells to meet the hemoglobin requirement INCLUSION CRITERIA FOR THIRD-LINE THERAPY: Patients may have a transfusion of red blood cells to meet the hemoglobin requirement Absolute neutrophil count (ANC) 1500/mm^3 within 3 weeks prior to study registration; blood transfusion to meet the inclusion criteria will not be allowed Blood transfusion to meet the inclusion criteria will be allowed Absolute neutrophil count ? 1,500. Blood transfusion to meet the inclusion criteria not be allowed. Absolute neutrophil count (ANC) >= 1500/mm^3 is necessary; blood transfusion to meet the inclusion criteria will not be allowed Platelet count > 100000/mm^3; blood transfusion to meet the inclusion criteria will not be allowed Hemoglobin (Hb) > 9 g/dL; blood transfusion to meet the inclusion criteria will not be allowed Absolute neutrophil count (ANC) >= 1500/mm^3; blood transfusion to meet the inclusion criteria will not be allowed Blood transfusion to meet the inclusion criteria will be allowed Absolute neutrophil count (ANC) >= 1,500/mm^3; blood transfusion to meet the inclusion criteria will not be allowed Blood transfusion to meet the inclusion criteria will not be allowed Note: supportive care (e.g. transfusion of red blood cells) is allowed to meet eligibility criteria Platelet count >= 100,000/mm^3; blood transfusion to meet the inclusion criteria will not be allowed Hemoglobin (Hb) >= 9 g/dL; blood transfusion to meet the inclusion criteria will not be allowed Absolute neutrophil count (ANC) >= 1500/mm^3; blood transfusion to meet the inclusion criteria will not be allowed Platelet count ? 100,000 /mm3, hemoglobin (Hb) ? 9 g/dL, absolute neutrophil count (ANC) ? 1500/mm3. Blood transfusion to meet the inclusion criteria will not be allowed. Platelet count >= 100,000/mm^3; blood transfusion to meet the inclusion criteria will not be allowed Hemoglobin (Hb) >= 9 g/dL; blood transfusion to meet the inclusion criteria will not be allowed Absolute neutrophil count (ANC) >= 1500/mm^3; blood transfusion to meet the inclusion criteria will not be allowed Platelet count >= 100000/mm^3; blood transfusion to meet the inclusion criteria will not be allowed Hemoglobin (Hb) >= 9 g/dL; blood transfusion to meet the inclusion criteria will not be allowed Absolute neutrophil count (ANC) >= 1500/mm^3; blood transfusion to meet the inclusion criteria will not be allowed Blood transfusion to meet the inclusion criteria will be allowed Platelet count >= 100,000/mm^3; blood transfusion to meet the inclusion criterion will not be allowed Hemoglobin (Hb) >= 9 g/dL; blood transfusion to meet the inclusion criterion will not be allowed Absolute neutrophil count (ANC) >= 1500/mm^3; blood transfusion to meet the inclusion criterion will not be allowed Blood transfusion to meet the following laboratory requirements will not be allowed Platelet count >= 100,000/mm^3; blood transfusion to meet the inclusion criteria will not be allowed Hemoglobin (Hb) >= 9 g/dL; blood transfusion to meet the inclusion criteria will not be allowed Absolute neutrophil count (ANC) 1500/mm^3; blood transfusion to meet the inclusion criteria will not be allowed Blood transfusion to meet the inclusion criteria will not be allowed