Patients with any significant history of non-compliance to medical regimens or unwilling or unable to comply with the instructions given to them by the study staff Patient that is not able to understand or to comply with the study instructions and requirements, or has a history of non-compliance to the medical regimen Patients with any significant history of non-compliance to medical regimens or unwilling or unable to comply with the instructions given to him/her by the study staff Any significant history of non-compliance to medical regimens or unwilling or unable to comply with the instructions given to him/her by the study staff Non compliance to medications or medical instructions Patients with any significant history of non-compliance to medical regimens or unwilling or unable to comply with the instructions given to him/her by the study staff Participants with any significant history of non-compliance to medical regimens or unwilling or unable to comply with the instructions given to him/her by the study staff Patients with any significant history of non-compliance to medical regimens or unwilling or unable to comply with the instructions given to them by the study staff Participants with any significant history of non-compliance to medical regimens or unwilling or unable to comply with the instructions given to him/her by the study staff Patients with any significant history of non-compliance to medical regimens or unwilling or unable to comply with the instructions given to him/her by the study staff Patients with any significant history of non-compliance to medical regimens or unwilling or unable to comply with the instructions given to him/her by the study staff. Patients with any significant history of non-compliance to medical regimens or unwilling or unable to comply with the instructions given to him/her by the study staff Patients with any significant history of non-compliance to medical regimens or unwilling or unable to comply with the instructions given to him/her by the study staff Patients with any significant history of non-compliance to medical regimens or unwilling or unable to comply with the instructions given to him/her by the study staff Patients with any significant history of non-compliance to medical regimens or unwilling or unable to comply with the instructions given to him/her by the study staff. Patient that is not able to understand or to comply with the study instructions and requirements or has a history of non-compliance to the medical regimen