Serum bilirubin ? 1.5 x upper normal limit (UNL) except patients with Gilbert's syndrome Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) ? 2.5 x UNL but ? 5.0 x UNL in case of liver metastases; alkaline phosphatase (ALP) ? UNL but i) ? 2.5 x UNL in case of liver metastases and ii) ? 5 UNL in case of bone metastases; albumin ? 2.5 g/dl. Total bilirubin less than 1.5 x upper normal limit (UNL) Aspartate aminotransferase (AST) (SGOT) less than or equal to 3 x UNL Creatinine less than 1.5 x UNL Bilirubin =< 2 x UNL Bilirubin =< 5X UNL; Serum bilirubin =< 1.5 x upper normal limit (UNL), except patients with Gilbert's syndrome Serum alanine aminotransferase (ALT) =< 2 x UNL or =< 5.0 x UNL in case of liver metastases Serum aspartate aminotransferase (AST) =< 2 x UNL or =< 5.0 x UNL in case of liver metastases Bilirubin =< 1.5 x UNL Bilirubin =< 3 x UNL, values =< 2 weeks Aspartate aminotransferase (AST/serum glutamic oxaloacetic transaminase [SGOT]) =< 3 x upper normal limit (UNL), alanine aminotransferase (ALT/serum glutamate pyruvate transaminase [SGPT]) =< 3 x UNL (=< 5 x UNL if liver metastases present) Bilirubin =< 1.5 x UNL Aspartate aminotransferase (AST/serum glutamic oxaloacetic transaminase [SGOT]) =< 3 x upper normal limit (UNL), alanine aminotransferase (ALT/serum glutamate pyruvate transaminase [SGPT]) =< 3 x UNL (=< 5 x UNL if liver metastases present) Bilirubin =< 1.5 x UNL Bilirubin =< 1.5 x UNL obtained =< 2 weeks prior to enrollment Aspartate aminotransferase (AST/serum glutamic oxaloacetic transaminase [SGOT]) =< 3 x upper normal limit (UNL), alanine aminotransferase (ALT/serum glutamate pyruvate transaminase [SGPT]) =< 3 x UNL (=< 5 x UNL if liver metastases present) Bilirubin =< 1.5 x UNL Bilirubin < 2 x UNL Alkaline phosphatase > UNL or > 2.5 x UNL in case of liver metastases, or > 5 x UNL in case of bone metastases. ALT/AST > UNL or > 2.5 x UNL in case of liver metastases. creatinine: ?2 x UNL Bilirubin ? 1.5 x UNL ? 2 weeks Bilirubin =< 1.5 x UNL Total bilirubin =< 1.5 x upper normal limit (UNL) Creatinine =< 1 x UNL Bilirubin =< 1.5 x UNL Aspartate aminotransferase (AST)/(serum glutamic oxaloacetic transaminase [SGOT]) =< 3 x upper normal limit (UNL), alanine aminotransferase (ALT)/(serum glutamate pyruvate transaminase [SGPT]) =< 3 x UNL (=< 5x UNL if liver metastases present) Bilirubin =< 1.5 x UNL Aspartate aminotransferase (AST/serum glutamic oxaloacetic transaminase [SGOT]) =< 3 x upper normal limit (UNL), alanine aminotransferase (ALT/serum glutamate pyruvate transaminase [SGPT]) =< 3 x UNL (=< 5 x UNL if liver metastases present) Bilirubin =< 1.5 x UNL Transaminase > 3 x upper normal limit (UNL) Total bilirubin < 1.5 mg/dL or UNL Bilirubin =< 1.5 x UNL Total bilirubin =< 1.5 x institutional upper normal limit (UNL) or =< 3 x institutional UNL if known Gilbert’s syndrome Aspartate aminotransferase (AST) <2.5 x UNL