Patients with malignant pleural effusions that do not resolve after first-line systemic therapy. Patients with pleural effusions that have become too small for thoracentesis at the time of registration would be permitted on study, indicating a significant response to first-line systemic therapy.
Exudative, bloody, or cytological proven malignant effusions
Uncontrolled symptomatic ascites or pleural effusions within 6 months.
Patients with significant visceral fluid collections including ascites, pericardial effusions, pleural effusions or others may experience delayed clearance of methotrexate and inability tolerate the proposed study treatment; while these are not absolute exclusions the Study Chair or co-Chairs should be contacted to discuss possible enrollment; patients with significant ascites defined as European Association for the Study of the Liver >= grade 2, or with asymptomatic pleural effusions with an estimated size > 200 mL, or with symptomatic pleural effusion of any size will be excluded
Patients with clinically significant ascites or pleural effusions.
Greater than minimal, exudative, or cytologically positive pleural effusions
Chylous effusions associated with malignant disease
The presence of lung, liver, or known brain metastases, malignant pleural effusions, or malignant ascites
Patients with documented significant pleural or pericardial effusions unless they are thought to be secondary to their leukemia.
Symptomatic pleural effusions or ascites (requiring constant or intermittent drainage)
Clinically significant and/or rapidly accumulating ascites, pericardial and/or pleural effusions; mild ascites that does not preclude safe tumor biopsy as protocol specified is allowed at the discretion of the treating physician
Pleural effusions or ascites.
Patients with documented significant pleural or pericardial effusions unless they are thought to be secondary to their leukemia.
High volume peritoneal or pleural effusions requiring a tap more frequently than every 14 days; moderate to severe ascites
Uncontrolled effusion e.g., presence of third space fluid that, in the opinion of the investigator, cannot be successfully controlled by drainage\r\n* Note: Patients with small effusions remaining after pleurodesis are eligible; determination of eligibility based on pleural size will be determined by the principal investigator
Any clinical or radiological ascites or pleural effusions
Patients with large and recurrent pleural or peritoneal effusions requiring frequent drainage (e.g. weekly)
Subjects with malignant pleural effusions and malignant ascites
Patients with clinically significant pleural or pericardial effusions
Patients with documented significant pleural or pericardial effusions unless they are thought to be secondary to their leukemia
History of moderate or severe ascites, bleeding esophageal varices, hepatic encephalopathy or pleural effusions related to liver insufficiency within 6 months of screening
Presence of third space fluid that cannot be controlled by drainage\r\n* For patients who develop or have baseline clinically significant pleural effusions before or during initiation of pemetrexed therapy; consideration should be given to drain the effusion prior to chemotherapy administration
Presence of pleural effusions > 5 mm as measured by treating physician using standard radiologic measuring tools
Recent history (within 6 months) of uncontrolled symptomatic ascites or pleural effusions.
Pleural effusions that are minimal (i.e. not visible on chest x-ray) that are too small to safely tap are eligible
Patients with symptomatic effusions (pleural, pericardial, or peritoneal) and/or those who have required a procedure for symptomatic effusions within 4 weeks of start of dasatinib are ineligible
The presence of liver, or known brain metastases, malignant pleural effusions, or malignant ascites
Symptomatic ascites or pleural effusions
Exudative, bloody, or cytologically malignant effusions
Uncontrolled pleural, pericardial effusions, or ascites requiring recurrent drainage procedures
If pleural fluid is visible on CT scan thoracentesis to exclude malignancy should be obtained. Patients with effusions that are too small to tap are eligible.
Greater than minimal, exudative, or cytologically positive pleural effusions
History of ascites or pleural effusions, unless successfully treated.
Symptomatic effusions due to pleural, pericardial, or peritoneal metastasis of epithelial ovarian cancer
Patients with known moderate/severe pleural effusions that are unrelated to malignancy or established diagnosis of pulmonary arterial hypertension
The presence of known brain metastases, malignant pleural effusions, or malignant ascites; brain MRI is required at screening only if clinically indicated
Patients with clinically significant pleural or pericardial effusions
Patients with symptomatic effusions on account of pleural, pericardial or peritoneal metastases of melanoma
Known presence of central nervous system metastases, pleural effusions or ascites
Patients with a history of malignant pleural effusions are not eligible; pleural effusions considered by the investigator too small for a diagnostic thoracentesis are permissible
For metastatic solid tumors with documented malignant pleural and/or peritoneal effusions, patients must not be receiving specific therapy for the effusion or have an indwelling drain.
Patients with documented significant pleural or pericardial effusions unless they are thought to be secondary to their leukemia
Exudative, bloody, or cytologically malignant effusions
Patients with malignant pleural effusions or significant pericardial effusions
Patients with symptomatic effusions on account of pleural, pericardial or peritoneal metastases of melanoma
The participant has clinically significant third-space fluid collections, for example, ascites or pleural effusions that cannot be controlled by drainage or other procedures prior to study entry.
Ascites, pleural effusions, or osteoblastic bone metastases as the only site of disease.
Presence of large accumulation of ascites or pleural effusions, which would be a contraindication to the administration of methotrexate for GVHD prophylaxis
Recent history (within 6 months) of uncontrolled symptomatic ascites or pleural effusions.
All patients whom do not have malignant pleural effusions
Subject has bilateral pleural effusions, with both being at least moderate in size (greater than one-third of the hemithorax on CXR).
Chylous effusions associated with malignant disease
Epithelial ovarian cancer outside of the peritoneal cavity, with the exception of pleural effusions
Body cavity effusions not caused by primary effusion lymphoma nor chylous effusions directly related to lymphatic infiltration by KS