Patients must be able to swallow tablets whole Patients must be able to swallow tablets or capsules; a patient with any gastrointestinal disease that would impair ability to swallow, retain, or absorb drug is not eligible Patients must be able to swallow tablets Patients must be able to swallow tablets Patients must be able to swallow intact tablets Patients must be able to swallow intact tablets Patients must be able to swallow intact tablets Patients must be able to swallow intact tablets Patients must be able to swallow tablets Participants must be able to swallow ribociclib capsules or tablets Must be able to swallow ribociclib and everolimus capsules/tablets Must be able to swallow LEE011 and everolimus capsules/tablets Patients must be able to swallow tablets (or applesauce, if part of bioavailability \crushed\ six patient cohort) Able to swallow tablets. Patients must be able to swallow whole tablets or capsules; nasogastric or gastrostomy tube (G-tube) administration is not allowed Patients must be able to swallow whole tablets or capsules; nasogastric or gastrostomy tube (G-tube) administration is not allowed; any gastrointestinal disease which would impair ability to swallow, retain, or absorb drug is not allowed Participant must be able to swallow tablets or capsules. A participant with any gastrointestinal disease that would impair ability to swallow, retain, or absorb drug is not eligible. Patients must be able to swallow intact tablets Patients who are not able to swallow intact tablets are not eligible Has an inability to swallow tablets or capsules Able to swallow bicalutamide and ribociclib capsules/tablets. Be able to swallow tablets. Are able to swallow capsules and tablets. Patients must be able to swallow intact tablets; patients who cannot swallow intact tablets are not eligible Able to swallow the study drugs whole as tablets Patients must be able to swallow whole tablets CAPMATINIB EXCLUSION CRITERIA: Inability to swallow intact tablets or capsules CERITINIB EXCLUSION CRITERIA: Inability to swallow intact tablets or capsules REGORAFENIB EXCLUSION CRITERIA: Inability to swallow intact tablets or capsules ENTRECTINIB EXCLUSION CRITERIA: Inability to swallow intact tablets or capsules Patient has a condition that would prevent him or her from being able to swallow Toca FC tablets or absorb flucytosine. Inability to swallow tablets or capsules Part E: Are able to swallow capsules or tablets The subject must be able to swallow tablets, or receive tablets crushed and/or dispensed in water via nasogastric or orogastric tube. Patients must be able to swallow tablets and have no significant impairment in gastrointestinal absorption Patients who are not able to swallow capsules or tablets Must be able to swallow ribociclib and tamoxifen capsules/tablets Patients must be able to swallow tablets whole Patients must be able to swallow whole tablets or capsules; nasogastric or gastrostomy (G)-tube administration is not allowed; any gastrointestinal disease which would impair ability to swallow, retain, or absorb drug is not allowed Patients must be able to swallow capsules/tablets Patients must be able to swallow whole tablets; nasogastric or gastrostomy (G) tube administration is not allowed; tablets must not be crushed or chewed For subjects to be enrolled in Cohort 4: Able to swallow and retain orally administered tablets Are able to swallow capsules and tablets. Must be able to swallow ribociclib / placebo capsules/tablets Inability to swallow tablets or capsules Able to swallow tablets Patients must be willing and able to swallow oral tablets Are able to swallow tablets Patients must be able to swallow tablets Patients with an inability to swallow tablets or capsules Are able to swallow capsules or tablets Patients must be able to swallow tablets Able to swallow tablets Ability to swallow intact palbociclib capsules and bicalutamide tablets Patients must be able to swallow whole tablets (for MK-2206); nasogastric or gastrostomy (G) tube administration is not allowed; tablets must not be crushed or chewed Patients who are not able to swallow capsules or tablets Patients must be able to swallow whole tablets; nasogastric or gastrostomy (G) tube administration is not allowed; tablets must not be crushed or chewed Patients must be able to swallow tablets whole, without crushing Patients must be able to swallow whole tablets; tablets must not be crushed or chewed Patients must be able to swallow whole tablets and capsules Patient must be able to swallow whole tablets Patients must be able to swallow tablets Patients must be able to swallow tablets Must be able to swallow tablets and capsules GENERAL INCLUSION CRITERIA FOR SUBPROTOCOLS: Patients must be able to swallow intact capsules/tablets, unless otherwise specified in the subprotocol to which they are assigned Subjects must be able to swallow capsules/tablets Patients must be able to swallow whole tablets or capsules; nasogastric or g-tube administration is not allowed; any gastrointestinal disease which would impair ability to swallow, retain, or absorb drug is not allowed