Voluntarily consents to participate and provides written informed consent prior to any protocol-specific procedures Provide written informed consent prior to any study-specific screening procedures Able to provide written informed consent prior to the performance of any study-specific procedures. Provide written informed consent obtained prior to the initiation of study procedures Patients must provide written informed consent prior to any study procedures Provide written informed consent prior to study-specific screening procedures, with the understanding that the patient has the right to withdraw from the study at any time, without prejudice The ability to provide written informed consent prior to study specific screening procedures, with the understanding that the patient has the right to withdraw from the study at any time Provide written informed consent prior to any study-specific screening procedures. The subject must sign a written informed consent form prior to the initiation of any study procedures. Adult subjects unable to provide written informed consent on their own behalf will not be eligible for the study Provide written, informed consent to participate in the study and follow the study procedures Willing and able to provide written informed consent prior to performance of any study-specific procedures Be able to provide written, personally signed, and dated informed consent to participate in the study before completing any study-related procedures. As applicable, a parent/both parents or legally authorized representative (LAR) must provide signature of informed consent and there must be documentation of assent by the subject before completing any study-related procedures. Be willing and able to provide written informed consent prior to initiation of any study procedures Patients must provide written informed consent prior to any screening procedures Provide written, informed consent to participate in the study and follow the study procedures Ability to give written, informed consent prior to any study-specific screening procedures, with the understanding that the consent may be withdrawn by the patient at any time without prejudice. Willing and able to provide written, signed informed consent after the nature of the study has been explained, and prior to any research-related procedures Willing and able to provide written informed consent prior to initiation of any study-related procedures Provide informed consent and agree to all assessments and study procedures Patients or their legal representatives must have the ability to read, understand and provide written informed consent for the initiation of any study related procedures. Written informed consent prior to any study-specific screening procedures with the understanding that the patient may withdraw consent at any time without prejudice Written informed consent prior to initiation of any study-related procedures; Must be willing to provide informed consent prior to any study specific procedures The subject must be able to provide written, personally signed, and dated informed consent to participate in the study before completing any study-related procedures. As applicable, a parent/both parents or legally authorized representative (LAR) must provide signature of informed consent and there must be documentation of assent by the subject before completing any study-related procedures. Subjects must provide a signed informed consent before any screening procedures Patients must provide written informed consent prior to any screening procedures Provide written, informed consent to participate in the study and follow the study procedures Patients must provide written informed consent prior to any screening procedures Following receipt of verbal and written information about the study, patients must provide signed informed consent before any study-related activity is carried out. Provide written, informed consent to participate in the study and follow the study procedures Ability to voluntarily provide informed consent to participate prior to any study-related assessments/procedures being conducted Patients must provide written informed consent prior to performance of study-specific procedures or assessments, and must be willing to adhere with treatment and follow-up Willing and able to provide written, signed informed consent after the nature of the study has been explained, and prior to any research-related procedures Patients must provide written informed consent prior to performance of study-specific procedures or assessments and must be willing to comply with treatment and follow-up Provide written, informed consent to participate in the study and follow the study procedures Written informed consent granted prior to initiation of any study-specific screening procedures, given with the understanding that the patient has the right to withdraw from the study at any time, without prejudice Have given written informed consent prior to any study procedures Provide signed informed consent after receipt of oral and written information about the study and before any study-related activity is performed Patients must provide written informed consent prior to performance of study-specific procedures or assessments, and must be willing to adhere with treatment and follow-up Understands the potential risks and benefits of study participation and is willing to provide written informed consent. Subjects must provide written informed consent prior to performance of study-specific procedures or assessments, and must be willing to comply with treatment and follow-up Subjects must provide written informed consent prior to performance of study-specific procedures or assessments, and must be willing to comply with treatment and follow up Able to provide written informed consent prior to any study specific screening procedures with the understanding that the patient has the right to withdraw from the study at any time, for any reason without prejudice Provide written informed consent prior to any study procedures. Willing and able to provide written informed consent prior to performance of any study-specific procedures Willing to adhere to protocol specific requirements 12. Following receipt of verbal and written information about the study, the subject must provide signed informed consent before any study related activity is carried out. 13. Clinically significant toxic effects of prior therapy (expect hydroxyuria) resolved to Grade ? 1 before the start of study. Following receipt of verbal and written information about the study, patients must provide signed informed consent before any study-related activity is carried out. Provide written informed consent prior to any screening procedures Provide written informed consent prior to any screening procedures Provide written informed consent prior to any study-specific procedures Written informed consent prior to any study specific screening procedures with the understanding that the patient may withdraw consent at any time without prejudice PATIENT EXCLUSION: Unable to provide informed consent or complete study procedures as determined by clinical or study staff CAREGIVER EXCLUSION: Unable to provide informed consent or complete study procedures as determined by clinical or study staff Patients must provide written informed consent prior to any screening procedures Written informed consent prior to any study-related procedures Written informed consent prior to any study-related procedures Patients must provide written informed consent prior to any screening procedures Provide informed consent and agree to all assessments and study procedures. Provide informed consent and agree to all assessments and study procedures Provide informed consent and agree to all assessments and study procedures Patients or their legal representatives must have the ability to read, understand and provide written informed consent for the initiation of any study related procedures Patients or their legal representatives must have the ability to read, understand and provide written informed consent for the initiation of any study related procedures INCLUSION CRITERIA (NEXT 60 PATIENTS WITH LOCALLY ADVANCED PROSTATE CANCER): Patients or their legal representatives must have the ability to read, understand and provide written informed consent for the initiation of any study related procedures Patients or their legal representatives must have the ability to read, understand and provide written informed consent for the initiation of any study related procedures The subject must sign a written informed consent form prior to the initiation of any study procedures. Adult subjects unable to provide written informed consent on their own behalf will not be eligible for the study. Provide written informed consent prior to any study-specific screening procedures Willing and able to provide written, signed informed consent after the nature of the study has been explained, and prior to any research-related procedures Understand and provide written informed consent prior to initiation of any study-specific procedures.