Known inherited predisposition to bleeding or thrombosis Known inherited predisposition to bleeding or thrombosis Known inherited predisposition to bleeding or thrombosis Known inherited predisposition to bleeding or thrombosis Known inherited predisposition to bleeding or thrombosis Known inherited predisposition to bleeding or thrombosis Known inherited predisposition to bleeding or thrombosis History of thrombosis due to a known inherited hypercoagulable state Known inherited predisposition to bleeding or thrombosis Inherited predisposition to bleeding or thrombosis Known inherited predisposition to thrombosis Known predisposition to bleeding Any patient with a known or suspected inherited predisposition to cancer should be discussed with the study team prior to screening for eligibility\r\n* Patients with a known inherited or constitutional predisposition to transplant morbidities, including, but not limited to Fanconi anemia, Dyskeratosis Congenita, Shwachman-Diamond syndrome and Down syndrome will be excluded\r\n* Patients with known inherited or constitutional predisposition to non-hematologic cancers including, but not limited to Li-Fraumeni syndrome, BRCA1 and BRCA2 mutations will be excluded\r\n* Patients with an inherited predisposition to leukemia or otherwise hematologic malignancies that have not been associated with predisposition to transplant morbidities or non-hematologic cancers will not be excluded For patient with known history or predisposition to cardiac abnormalities: in the Investigator's opinion the history/predisposition should not jeopardize patient's safety during the study.