Inability to comply with protocol-required procedures Subject likely to not be available to complete all protocol-required study visits or procedures, and/or to comply with all required procedures. Subjects likely to not be available to complete all protocol-required study visits or procedures, and/or to comply with all required study procedures to the best of the subject and investigator's knowledge Central nervous system (CNS) diseases and major psychiatric diseases or inability to comply to the protocol procedures Inability to comply with protocol required procedures Subject likely to not be available to complete all protocol required study visits or procedures to the best of the subject and investigator's knowledge Inability to comply with protocol or study procedures Inability to comply with protocol required procedures Inability to comply with protocol or study procedures 223 Subjects likely to not be available to complete all protocol- required study visits or procedures including BM aspirates/biopsies, and/or to comply with all required study procedures to the best of the subject and investigator's knowledge. Subject likely to not be available to complete all protocol-required study visits or procedures, and/or to comply with all required study procedures to the best of the subject's and investigator's knowledge. Inability to comply with protocol required procedures. Inability to comply with protocol or study procedures Inability to comply with protocol required procedures Patient must be able to tolerate the procedures required in this study including periodic blood sampling, study related assessments, and management at the treating institution for the duration of the study. Inability to comply with protocol or study procedures (for example, an inability to swallow tablets) will be an exclusion criterion. Inability to comply with protocol or study procedures 201 Subject likely to not be available to complete all protocol-required study visits or procedures, and/or to comply with all required study procedures to the best of the subject and investigator's knowledge. Stated willingness to comply with all required (non-optional) study procedures and be available for the duration of the study Subject likely to not be available to complete all protocol-required study visits or procedures, and/or to comply with all required study procedures to the best of the subject and investigator's knowledge.