No evidence of dyspnea at rest, no exercise intolerance due to pulmonary insufficiency, and a pulse oximetry > 92% while breathing room air Pulse oximetry > 94% on room air if there is clinical indication for determination (e.g. dyspnea at rest) Pulse oximetry > 94% on room air if there is clinical indication for determination (e.g. dyspnea at rest) No evidence of dyspnea at rest, no exercise intolerance, and a pulse oximetry > 94% if there is clinical indication or determination; pulmonary function tests (PFTs) are not required No evidence of dyspnea at rest, no exercise intolerance, and a resting pulse oximetry reading > 94% on room air if there is clinical indication for determination No evidence of dyspnea at rest, no exercise intolerance, and a pulse oximetry > 94% at sea level if there is clinical indication for determination For children who are unable to cooperate for PFTs, the criteria are: no evidence of dyspnea at rest, no exercise intolerance, and a pulse oximetry reading of > 92% on room air Patients with a history of pulmonary dysfunction must have no evidence of dyspnea at rest, no exercise intolerance due to pulmonary insufficiency, and a pulse oximetry > 92% while breathing room air unless current dysfunction is due to the lymphoma in which case the patient is eligible Pulse oximetry > 94% on room air if there is clinical indication for determination (e.g. dyspnea at rest) Patients must have normal pulmonary function testing for age based on pulse oximetry Pulse oximetry > 93% on room air and no evidence of dyspnea at rest INCLUSION CRITERIA FOR STRATUM C: Pulse oximetry > 93% on room air and no evidence of dyspnea at rest Pulse oximetry >= 94% if there is clinical indication for determination No evidence of dyspnea at rest, no exercise intolerance, and a pulse oximetry > 94% No evidence of dyspnea at rest, no exercise intolerance, and a pulse oximetry > 94% Adequate pulmonary function as defined as: no evidence of dyspnea at rest, no exercise intolerance, and a pulse oximetry > 94% if there is clinical indication for determination No evidence of dyspnea at rest and pulse oximetry > 94% For children who are unable to perform pulmonary function tests but have no evidence of dyspnea at rest nor exercise intolerance nor abnormal chest X-ray (CXR), a pulse oximetry > 94% on room air is acceptable Patients must have no evidence of dyspnea at rest and a pulse oximetry > 92% while breathing room air RANDOMIZED PHASE II (ARMS K AND L): Patients must have no evidence of dyspnea at rest and a pulse oximetry > 92% while breathing room air Pulse oximetry > 94% if there is clinical indication for determination For children who are uncooperative for pulmonary function tests and have no evidence of dyspnea at rest or exercise intolerance, pulse oximetry > 94% on room air is considered acceptable, with a normal chest X-ray No evidence of dyspnea at rest, no history of exercise intolerance, and a pulse oximetry > 94% Adequate pulmonary function defined as:\r\n* No evidence of dyspnea at rest, no exercise intolerance, no chronic oxygen requirement, and room air pulse oximetry > 94% if there is a clinical indication for pulse oximetry; normal pulmonary function tests in patients who are capable of cooperating with testing (including diffusion capacity of the lung of carbon monoxide [DLCO]) are required if there is a clinical indication for determination; for patients who do not have respiratory symptoms, full pulmonary function tests (PFTs) are NOT required No evidence of dyspnea at rest, no exercise intolerance due to pulmonary insufficiency, and a pulse oximetry > 92% while breathing room air No evidence of dyspnea at rest and a pulse oximetry > 94% if there is clinical indication for determination Patients must not have any evidence of dyspnea at rest, exercise intolerance, and must have a pulse oximetry > 94% at sea level A pulse oximetry ? 94% at sea level (? 90% at altitude ? 5000 feet) if there is clinical indication for determination. No evidence of dyspnea at rest, no exercise intolerance, and a pulse oximetry > 94% in room air, if there is clinical indication for determination For children who are unable to perform pulmonary function testing, no evidence of dyspnea at rest, no exercise intolerance, and a pulse oximetry > 94% on room air For children who are unable to perform pulmonary function testing, no evidence of dyspnea at rest, no exercise intolerance, and a pulse oximetry > 92% in room air