Serum potassium > 3.5 mmol/L Parts C2 and D2
Serum potassium >= 3.5 mmol/L performed within 30 days prior to the date of registration (if < 3.5, can be repleted and reassess for eligibility as long as stable off potassium supplementation for > 48 hours [hrs])
Obtained within 14 days prior to registration: Potassium > 3.5 mmol/L (within institutional normal range)
Serum potassium ? 3.5 mmol/L. Supplementation and re-screening is allowed.
Documented within 14 days of registration: Sodium: >= 130 and =< 145 mmol/L
Documented within 14 days of registration: Potassium: 3.4- 4.8 mmol/L
The following metabolic values will exclude patients from study enrollment: \r\n* Serum calcium (ionized or adjusted for albumin) < 7 mg/dl (1.75 mmol/L) or > 12.5 mg/dl (> 3.1 mmol/L) despite intervention to normalize levels\r\n* Magnesium < 0.9 mg/dl (< 0.4 mmol/L) or > 3 mg/dl (> 1.23 mmol/L) despite intervention to normalize levels; Note: patients with an initial magnesium < 0.5 mmol/L (1.2 mg/dl) may receive corrective magnesium supplementation but should continue to receive either prophylactic weekly infusion of magnesium and/or oral magnesium supplementation (eg, magnesium oxide) at the investigator’s discretion\r\n* Potassium < 3.5 mmol/L or > 6 mmol/L despite intervention to normalize levels\r\n* Sodium < 130 mmol/L or > 155 mmol/L despite intervention to normalize levels
Serum potassium >= 3.5 mmol/L
Serum potassium >= 3.5 mmol/L
Serum potassium ? 3.5 mmol/L
Serum potassium >= 3.5 mmol/L.
Potassium > 3 and < 5.5 mmol/L.
Potassium >= 3.5 mmol/L (within institutional normal range) within 14 days of cycle 1 day 1
Within 14 days of registration: Potassium >= 3.5 mmol/L (within institutional normal range)
Serum potassium >= 3.5 mmol/L
Serum potassium < 3.5 mmol/L
Serum potassium >= 3.5 mmol/L
Serum potassium >= 3.5 mmol/L
Within 3 months of registration: Serum potassium >= 3.5 mmol/L
Potassium < 3.5 mmol/L or > 6 mmol/L despite intervention to normalize levels
Chloride 98-107 mmol/L
Within 28 days of study registration: Potassium >= 3.5 mmol/L
Potassium < 3.0 mmol/L or > 6 mmol/L despite intervention to normalize levels
Sodium < 130 mmol/L or > 155 mmol/L despite intervention to normalize levels
Potassium < 3.0 mmol/L or > 6 mmol/L despite intervention to normalize levels
Sodium < 130 mmol/L or > 155 mmol/L despite intervention to normalize levels
Grade 3-4 electrolyte abnormalities (Common Terminology Criteria for Adverse Events [CTCAE], version [v]. 4):\r\n* Serum calcium (ionized or adjusted for albumin) < 7 mg/dl (1.75 mmol/L) or > 12.5 mg/dl\r\n(> 3.1 mmol/L) despite intervention to normalize levels\r\n* Magnesium < 0.9 mg/dl (< 0.4 mmol/L) or > 3 mg/dl (> 1.23 mmol/L) despite intervention to normalize levels\r\n* Potassium < 3.5 mmol/L or > 6 mmol/L despite intervention to normalize levels\r\n* Sodium < 130 mmol/L or > 155 mmol/L despite intervention to normalize levels
Serum potassium < 4.0 mmol/L or above 5.0 mmol/L
Patients with hyponatremia (sodium < 130 mmol/L)
Performed within 14 days of patient registration: Serum potassium > 3.8 mmol/L (can be achieved with replacement)
Severe, active co-morbidity, defined as follows:\r\n* Unstable angina and/or congestive heart failure requiring hospitalization within 6 months prior to registration\r\n* Transmural myocardial infarction within 6 months prior to registration\r\n* Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration\r\n* Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration\r\n* Idiopathic pulmonary fibrosis or other severe interstitial lung disease that requires oxygen therapy or is thought to require oxygen therapy within 1 year prior to registration\r\n* Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects; note, however, that laboratory tests for coagulation parameters are not required for entry into this protocol\r\n* Acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition; note: human immunodeficiency virus (HIV) testing is not required for entry into this protocol; protocol-specific requirements may also exclude immuno-compromised patients\r\n* Grade 3-4 electrolyte abnormalities (CTCAE, v. 4):\r\n** Serum calcium (ionized or adjusted for albumin) < 7 mg/dl (1.75 mmol/L) or > 12.5 mg/dl (> 3.1 mmol/L) despite intervention to normalize levels\r\n** Glucose < 40 mg/dl (< 2.2 mmol/L) or > 250 mg/dl (> 14 mmol/L)\r\n** Magnesium < 0.9 mg/dl (< 0.4 mmol/L) or > 3 mg/dl (> 1.23 mmol/L) despite intervention to normalize levels\r\n** Potassium < 3.0 mmol/L or > 6 mmol/L despite intervention to normalize levels\r\n** Sodium < 130 mmol/L or > 155 mmol/L despite intervention to normalize levels
Potassium 3.4 – 5.0 mmol/L
Serum potassium >= 3.5 mmol/L
Have a baseline serum potassium >= 3.5 mmol/L
Serum potassium >= 3.5 mmol/L
Potassium levels < 3.5 mmol/L or > 5.1 mmol/L
Obtained within 14 days prior to registration: Potassium >= 3.5 mmol/L
Serum potassium (K)+ < 3.5 mmoL/L; patients with a K+ < 3.5 mmoL/L are required to have a documented subsequent K+ > 3.5 prior to enrollment to be eligible
Serum sodium level is ? 130 mmol/L
Serum sodium level ? 130 mmol/L
Serum sodium greater than 120 mmol/L
13.9 mmol/L]).
Potassium <3.5 mmol/L.
Serum potassium >= 3.8 mmol/L
Serum potassium greater than 3.5 mmol/L without oral supplementation
Serum sodium level is ? 130 mmol/L
Serum potassium >= 3.5 mmol/L
Serum potassium >= 3.8 mmol/L
Potassium 3.2-4.8 mmol/L (inclusive)
Serum potassium >= 3.5 mmol/L
Hyponatremia (sodium < 135 mmol/L)