New York Heart Association > Grade 2 congestive heart failure within 6 months prior to study entry, unless asymptomatic and well controlled with medication New York Heart Association (NYHA) status of less than or equal to (2, Clinically significant heart failure (New York Heart Association [NYHA] > 2), recent myocardial infarction, or symptomatic atrial fibrillation Pre-existing cardiovascular disease (including congestive heart failure, New York Heart Association [NYHA] grade III/IV), or arrhythmia known to increase the risk of thromboembolic events (e.g. atrial fibrillation), or subjects with a corrected QT interval (QTc) > 450 msec Active grade III-V cardiac failure as defined by the New York Heart Association criteria New York Heart Association stage 3 or 4 cardiac disease. Active grade III-V cardiac failure as defined by the New York Heart Association criteria. Active grade III-V cardiac failure as defined by the New York Heart Association criteria. New York Heart Association stage 3 or 4 cardiac disease. Congestive cardiac failure of > grade 2 severity according to the New York Heart Association (NYHA) defined as symptomatic at less than ordinary levels of activity Congestive heart failure requiring treatment (New York Heart Association [NYHA] grade >= 2) Congestive heart failure requiring treatment (New York Heart Association [NYHA] grade >= 2) Cardiovascular disease resulting in New York Heart Association function status of ? 3. Uncontrolled arterial hypertension or congestive heart failure (New York Heart Association Classification 3 or 4) (Appendix B). Patients with >= New York Heart Association (NYHA) grade 3 heart disease as assessed by history and/or physical examination Active grade III-V cardiac failure as defined by the New York Heart Association criteria Heart failure >= New York Heart Association (NYHA) grade 3 Grade III/IV congestive heart failure, as defined by New York Heart Association (NYHA) criteria, or myocardial infarction within 6 months Congestive heart failure (New York Heart Association [NYHA classification]) Congestive heart failure (New York Heart Association {NYH Congestive heart failure (New York Heart Association ? Grade 2) New York Heart Association >/= Grade 3 congestive heart failure within 6 months prior to study entry History of congestive heart failure of any New York Heart Association (NYHA) criteria Patients must not have unstable angina or New York Heart Association (NYHA) classification of congestive heart failure of grade >= 2 Moderate or severe heart disease based on New York Heart Association (NYHA) criteria Uncontrolled intercurrent illness including, but not limited to, the following:\r\n* Active infection\r\n* Congestive heart-failure (New York Heart Association [NYHA] grade III or IV) Heart failure ?3 (New York Heart Association(NYHA)) History of cardiac heart failure of any New York Heart Association criteria or serious cardiac arrhythmia requiring treatment New York Heart Association functional classification for congestive heart failure (NYHA CHF) < 3 Subjects with classification of 3 or higher heart failure as classified by the New York Heart Association (NYHA) Patients with pre-existing cardiovascular disease (including congestive heart failure, New York Heart Association [NYHA] grade III-IV), or arrhythmia known to increase the risk or thromboembolic events (e.g., atrial fibrillation) New York Heart Association Stage 3 or 4 cardiac disease Congestive heart failure or New York Heart Association (NYHA) status >= 2 Congestive heart failure or New York Heart Association (NYHA) status >= 2 Congestive heart failure or New York Heart Association (NYHA) status >= 2 Congestive heart failure or New York Heart Association (NYHA) status >= 2