Known history of acute or chronic pancreatitis Known history of acute or chronic pancreatitis Recurrent or chronic pancreatitis Known active or chronic pancreatitis Patients with acute or chronic liver, renal disease or pancreatitis Acute symptomatic pancreatitis within 6 months of study entry or a diagnosis of chronic pancreatitis at the time of randomization. Known acute or chronic pancreatitis Patients with acute or chronic liver, renal disease or pancreatitis Known history of acute or chronic pancreatitis Patients with acute or chronic liver, renal, lung disease or pancreatitis Patients with acute or chronic liver, renal disease or pancreatitis Acute or chronic pancreatitis Subject has known acute or chronic pancreatitis. Known symptomatic acute or chronic pancreatitis. Known history of acute or chronic pancreatitis Active or chronic pancreatitis Patients with acute or chronic liver, renal disease or pancreatitis Has a history of acute or chronic pancreatitis Patients with acute or chronic liver, renal disease or pancreatitis Diagnosis of acute or chronic pancreatitis Acute or chronic pancreatitis Acute or chronic renal disease or pancreatitis Presence of acute or chronic liver, renal disease, or pancreatitis Subjects with acute or chronic pancreatitis. Active or clinically symptomatic chronic pancreatitis or disease affecting pancreas Acute or chronic pancreatitis. Patients with acute or chronic liver, renal disease or pancreatitis History of acute or chronic pancreatitis Known acute or chronic pancreatitis 17. Pregnant or lactating females Arm B only (CC-122 in combination with ibrutinib): Acute or chronic pancreatitis Acute or chronic pancreatitis Patients with acute or chronic liver, renal disease, or pancreatitis Known gallbladder or bile duct disease, acute or chronic pancreatitis Known gallbladder or bile duct disease, symptomatic cholelithiasis, acute or chronic pancreatitis Indication for operative intervention being chronic pancreatitis At least two episodes of acute pancreatitis in the past 12 months; acute pancreatitis is defined any 2 of the following: (1) typical upper abdominal pain; (2) elevation in serum amylase or lipase >= 3 times upper limit of normal; (3) features of acute pancreatitis on cross-sectional imaging Known symptomatic acute or chronic pancreatitis. Acute or chronic pancreatitis Chronic or acute pancreatitis as evidenced by clinical or pathologic diagnosis