Known or suspected brain metastasis or active leptomeningeal disease Brain metastasis and/or leptomeningeal disease (known or suspected) Known or suspected brain metastasis or active leptomeningeal disease Known or suspected brain metastasis or active leptomeningeal disease. Patients with known or suspected brain metastasis Subjects with known or suspected brain metastasis, or brain as the only site of disease are excluded with the following exceptions Patients with known or suspected brain metastasis or active leptomeningeal disease Known or suspected brain metastasis or active leptomeningeal disease Known or suspected brain metastasis or active leptomeningeal disease For Cohort C:Has known or suspected brain metastasis or leptomeningeal carcinomatosis Known or suspected brain metastasis or active leptomeningeal disease; Subject has known or suspected brain metastasis or active leptomeningeal disease. Known or suspected brain metastasis or active leptomeningeal disease; Known or suspected brain metastasis Subject has known or suspected brain metastasis or active leptomeningeal disease. Known or suspected brain metastasis or active leptomeningeal disease Suspected or known CNS metastasis Known or suspected brain metastasis or active leptomeningeal disease Known or suspected brain metastasis or active leptomeningeal disease Known or suspected brain metastasis or leptomeningeal disease. Known or suspected brain metastasis; Known or suspected brain metastasis or active leptomeningeal disease Known or suspected brain metastasis or leptomeningeal disease Active known or suspected brain metastasis or active leptomeningeal disease needing treatment Active known or suspected brain metastasis or active leptomeningeal disease undergoing or requiring treatment.