Clinically confirmed as postmenopausal. Participants must be fully postmenopausal Postmenopausal status, defined as no menstrual cycle for 12 months or surgical removal of ovaries A woman is considered to be of childbearing potential if she is not postmenopausal, has not reached a postmenopausal state (? 12 continuous months of amenorrhea with no identified cause other than menopause), and has not undergone surgical sterilization (removal of ovaries and/or uterus). Only females are eligible. Menopausal status: i. Postmenopausal defined by: Female participants must be either postmenopausal defined as: Patients can be premenopausal or postmenopausal Female participants must be either postmenopausal defined as: Postmenopausal women\r\n* Postmenopausal if satisfies one or more of the following criteria: age greater than 52 years of age; having had a bilateral oophorectomy; amenorrhoeic for at least 12 months Postmenopausal woman Postmenopausal defined as: For Part 1, postmenopausal women only Patient is postmenopausal woman defined as either: Be postmenopausal (defined as amenorrheic for at least 12 months) have postmenopausal status If female, patient is postmenopausal Postmenopausal women. Postmenopausal status is defined by the National Comprehensive Cancer Network as either: Postmenopausal status as defined by the protocol Postmenopausal women. Postmenopausal status is defined either by: Postmenopausal women Patient is postmenopausal Have postmenopausal status Postmenopausal status Postmenopausal women Subject is considered postmenopausal Men and pre- and postmenopausal women are eligible Patient is postmenopausal. Postmenopausal status is defined either by: Postmenopausal women Postmenopausal In premenopausal women, serum estradiol level in postmenopausal range =< 7 days prior to registration Patient is postmenopausal. Premenopausal or postmenopausal women Have postmenopausal status. Postmenopausal status Postmenopausal status. Postmenopausal for at least 1 year OR Must be female and postmenopausal. Postmenopausal women Postmenopausal women Have been postmenopausal for ?1 year Postmenopausal women, defined by lack of a menstrual period for an entire year All women will be postmenopausal, defined as having follicle-stimulating hormone (FSH) and estradiol within the institutional postmenopausal range at the time of study entry and no menstrual cycle in the last 12 months Women who are postmenopausal by surgery, radiotherapy, or presence of natural amenorrhea >= 12 months Postmenopausal women are defined as those with their last menstrual period more than 12 months prior to study entry; for the purpose of defining menopausal status for women who have had surgical cessation of their periods, women who no longer have menses due to hysterectomy and oophorectomy will be considered postmenopausal; women who no longer have menses due to hysterectomy without oophorectomy will be considered premenopausal until age 52 and postmenopausal thereafter All other postmenopausal women are eligible for inclusion in the biennial screening regimen Postmenopausal women (defined per provider discretion and notated in the medical record) The study will be conducted in postmenopausal women Postmenopausal women Postmenopausal women. Postmenopausal status is defined either by: Postmenopausal (no menstrual cycle in the past 12 months) Participant must be a non-Hispanic white or non-Hispanic black (self-reported race) woman 45 to 80 years of age and postmenopausal; postmenopausal will be defined as no menstrual cycle in the past 12 months; women with a hysterectomy but with intact ovaries will be included if aged >= 55 years Postmenopausal women defined as women with: Women must be postmenopausal (defined as no menstrual cycle for 12 months or surgical history of bilateral salpingoopherectomy); postmenopausal women of all races and ethnic groups are eligible to participate for this trial; men are not eligible\r\n* Note: women who have had a hysterectomy without a bilateral salpingoopherectomy may still be pre-menopausal; confirmation of postmenopausal status is required for these patients and will be measured by testing levels of estradiol, progesterone and follicle stimulating hormone (FSH) (lab ranges per institutional standards); in addition, confirmation of postmenopausal status may be performed in any patient with unclear menopausal status per treating physician discretion