Patients’ disease must not have micropapillary components Patient has a known hypersensitivity to any of the components of the study drug Known hypersensitivity to any of the components of nal-IRI, other liposomal products, fluoropyrimidines or leucovorin Known hypersensitivity to the components of MM-310, or docetaxel Known hypersensitivity to any of the components of RO6874281 For Part B exclusively, known hypersensitivity to any of the components of trastuzumab For Part C exclusively, known hypersensitivity to any of the components of cetuximab Known allergy, hypersensitivity, or contraindication to paclitaxel, docetaxel, or irinotecan or any components used in their preparation Patients with known hypersensitivity to any of the components of CBL0137; Known hypersensitivity to the components of niraparib components or their formulation excipients Known hypersensitivity to ferumoxytol or any of its components History of, or known, hypersensitivity to any components of melphalan or the components of the Melphalan/HDS system. Prior hypersensitivity to any of the components of the study drugs Any known hypersensitivity or contraindication to the components of the study drug AZD1775 No known hypersensitivity or contraindication to the components of study treatment (M6620 [VX-970], gemcitabine) Any known hypersensitivity or contraindication to the components of the study drug AZD1775 Known hypersensitivity to any of the components of the study drugs Known hypersensitivity to any of the components of M7824 or eribulin. Known hypersensitivity to any of the components of LMB-100 and/or SEL-110 Known hypersensitivity to any of the components of cabozantinib or nivolumab Participants with prior use of pirfenidone or known hypersensitivity to any of the components of study treatment will be excluded from the study History of hypersensitivity to Vicinium or its components Patients must not have a known hypersensitivity to the components of niraparib or the excipients Patient with documented hypersensitivity to any of the components of the therapy program Known hypersensitivity to the components of study drugs, its analogs, or drugs of similar chemical or biologic composition. A known allergy or history of hypersensitivity to silicon, phosphorous or any of the OncoSil™ components Patients with a known history of hypersensitivity to lomustine, dacarbazine, or any components of lomustine Patient has known hypersensitivity to the components of the study drugs or any analogs Patient has known hypersensitivity to the components of the study drugs or their analogs Known hypersensitivity to any of the components of LMB-100 Known hypersensitivity to any of the components of LMB-100 Known hypersensitivity to the components of study drugs, its analogs, or drugs of similar chemical or biologic composition Known hypersensitivity reactions to any of the components of Sym004 Patients with known allergy or hypersensitivity to selinexor, sorafenib or any of its components Patients with known hypersensitivity to the components of the study drugs or their analogs Patients with known allergy or hypersensitivity to nivolumab, ipilimumab, 5-azacytidine, or any of their components Patients with documented hypersensitivity to any components of the study program Patient with documented hypersensitivity to any of the components of the chemotherapy program Patients with known hypersensitivity to any of the components of PFK-158. Known hypersensitivity to any of the components of MM-398 or other liposomal products Tumor with ?25% IDC components Patients with known allergy or hypersensitivity to quizartinib, mannitol, AZA, cytarabine or any of their components. Patient has known hypersensitivity to the components of study drug or its analogs Patients with known hypersensitivity to the components of study drug or its analogs Patient with documented hypersensitivity to any of the components of the chemotherapy program Known hypersensitivity to enzalutamide or any of its components. Patients with a history of or known hypersensitivity to melphalan or the components of the Melphalan/HDS system. Have a history of hypersensitivity reaction to any of the components of Temozolomide Has known hypersensitivity to TAS-119 or its components. Has known hypersensitivity to Cremophor® EL, paclitaxel or its components. Any known hypersensitivity or contraindication to the components of the study drug AZD1775 Any known hypersensitivity or contraindication to the components of the study drug AZD1775 or olaparib. Known hypersensitivity to the components of study drugs or analogs of study drugs Patient with documented hypersensitivity to any of the components of the chemotherapy program Known hypersensitivity to any components of study drugs Have a known hypersensitivity to any of the components of AG-120, matched placebo, or azacitidine. Known hypersensitivity to any of the components of tazemetostat Known hypersensitivity to any of the products used in the trial-G-CSF (Neupogen), plerixafor, or any planned components of conditioning regimens Known documented or suspected hypersensitivity to the components of the study drug(s) or analogs Patients with known hypersensitivity to any of the components of oxaliplatin or mitomycin C Patients with known hypersensitivity to any of the components of oxaliplatin or mitomycin C Known hypersensitivity to any of the components of RO6958688 and/or obinutuzumab Hypersensitivity to ASTX660, excipients of the drug product, or other components of the study treatment regimen. Known hypersensitivity to any of the components of niraparib or prior hypersensitivity reactions to that class of drugs. Known hypersensitivity reaction to temozolomide or any of its components, or dacarbazine (DTIC) if enrolled on ARM 1 or irinotecan or any of its components if enrolled on ARM 2 Known hypersensitivity to any of the GTx-024 components or subjects previously received treatment with SARM Has known hypersensitivity to any of the components of IP. Subject has known hypersensitivity to immunoglobulins or any of the products or components to be administered during dosing. Known hypersensitivity to any of the components of MM-398, other liposomal products, fluoropyrimidines or leucovorin Known hypersensitivity to the components of the study therapy or its analogs. have a known allergy or hypersensitivity reaction to any of the treatment components Have a known allergy or hypersensitivity reaction to any of the treatment components. Patients who are known sensitive to any of the products or components to be administered during treatment with talimogene laherparepvec Patients with known allergy or hypersensitivity to lirilumab, 5-azacytidine, or any of their components; patients who have previously been treated with lirilumab in combination with 5-azacytidine will be excluded Known serious reactions or hypersensitivity to any components of the UV1 vaccine or similar peptide based vaccines Known hypersensitivity to the components of niraparib Known prior severe allergic/hypersensitivity to the chemotherapy or any of the components of the study treatment Subjects with known hypersensitivity to any of the components of AG-120. Subjects with known hypersensitivity to any of the components of AG-221. Known hypersensitivity to any components of the treatments Patients with a known hypersensitivity to any of the components of the drug products Patients with previous hypersensitivity reactions to the study drugs and components (ex: podophyllum and povidone). Hypersensitivity to one or more of the TL-118 active components History of hypersensitivity reactions to any components of the treatment regimen Any known hypersensitivity to ofatumumab or its components. Patient has known hypersensitivity to the components of study drug or its analogs Patients with a known hypersensitivity to any of the components of the drug products Has a known hypersensitivity to the components of the study treatment or its analogs. Known hypersensitivity to cyclophosphamide, its metabolites or any other components, or known urinary outflow obstruction. Patient has a known hypersensitivity to the components of study drugs, its analogues, or drugs of similar chemical or biologic composition Known hypersensitivity to any of the components of RO6927005 Patients with known hypersensitivity to any components of ME-344 or topotecan study drug product Any known hypersensitivity or contraindication to the components of study treatment Patient has hypersensitivity to any of the components of study drugs. Patients with known hypersensitivity to any of the components of AN-152 including doxorubicin and LH-RH agonists Subjects with known hypersensitivity to any components of ALKS 4230 Subjects with known hypersensitivity to any components of pembrolizumab (for patients in combination arm only) Known hypersensitivity to any of the treatment components of ramucirumab or LY2875358. Known hypersensitivity to the components of niraparib Patient has a known hypersensitivity to any of the components of the study drug. Known hypersensitivity to HDAC inhibitors or to any of the components of mocetinostat Known hypersensitivity to any of the components of AG-221 Known hypersensitivity to any components of the study drugs Patients with known hypersensitivity to any of the components of romidepsin or who have had hypersensitivity reactions to paclitaxel Patients with a known or suspected hypersensitivity to any of the components of OTS167. Known hypersensitivity to any components of SC16LD6.5 study drug product. Known significant hypersensitivity to any components of study treatment Patients with a known or suspected hypersensitivity to either gemcitabine or any of the components of PRI-724. Hypersensitivity of AT13387 or other components of the drug product Known hypersensitivity to the components of niraparib, PD-1 inhibitor, or their excipients Known hypersensitivity to the components of niraparib or excipients Known hypersensitivity to any of the components of PRI-724 Patients with a known hypersensitivity to any of the components of the drug products History of allergies or known hypersensitivity to any components of melphalan or the components of the Melphalan/HDS system Patients with known allergy or hypersensitivity to ponatinib, or 5-azacytidine, or any of their components Patient with known hypersensitivity to rocuronium, sugammadex or its components. Participants with known hypersensitivity to modafinil, armodafinil, or any of its components Patients with previous history of hypersensitivity to ribavirin or its components Have known hypersensitivity or allergy to eggs, egg or chicken protein, or other components of the study vaccine History of hypersensitivity to ribociclib or any of its components Patients with hypersensitivity to sonazoid or one of its components Hypersensitivity to CBT-101, excipients of the drug product, or other components of the study treatment regimen. Known hypersensitivity to the study drug or components of the preparation Known hypersensitivity to Feraheme (ferumoxytol) or any of its components Any known hypersensitivity or contraindication to the components of study treatment Patients with known hypersensitivity to any of the components of PEGPH20 or cetuximab* Patients may not have a known hypersensitivity to any of the components of ganetespib