Able to adhere to the study visit schedule and other protocol requirements Must be able to adhere to the study visit schedule and other protocol requirements. Subjects must agree to adhere to all study requirements, visit schedule, outpatient treatment, required concomitant medications, and laboratory monitoring Subject is willing and able to adhere to the study visit schedule and other protocol requirements. Able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Agree to adhere to all study protocol requirements. Able to comply with the study visit schedule and other protocol requirements. The patient is able to adhere to the study visit schedule and other protocol requirements, including follow-up for survival assessment. Must be able to adhere to the study visit schedule and other protocol requirements. Is willing and able to adhere to the study visit schedule and other protocol requirements including blood sampling and bone marrow aspiration. Able to adhere to study schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements in the opinion of the investigator. Able to adhere to the study visit schedule and other protocol requirements. Able to adhere to the study visit schedule and other protocol requirements Understand and voluntarily sign informed consent prior to any study-related assessments or procedures are conducted and are able adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Ability to adhere to the protocol requirements and study visit schedule. Subject (and when applicable, with parental/legal representative) is willing and able to adhere to the study visit schedule and other protocol requirements. Patient must be willing to give written informed consent and must be able to adhere to dosing and visit schedules, and meet all study requirements. Ability to adhere to the study visit schedule and other protocol requirements Ability to provide informed written consent and be able to adhere to the study visit schedule and other protocol requirements Ability to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Patient must be able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Ability to provide informed written consent and be able to adhere to the study visit schedule and other protocol requirements Patient is willing to participate to the study, has the ability to adhere to the study visit schedule and other protocol procedures, and has the ability to understand and signs an informed consent form Negative serum or urine pregnancy tests during screening and then within 3 days prior to Day 1. 12. Sexually active men - effective contraceptive methods in subject and partner from the time of informed consent and until ? 4 weeks after discontinuing study drugs. 13. Able to adhere to the study visit schedule and other protocol requirements. Able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements. Participant must be able to adhere to study visit/procedure schedule and protocol requirements Participant unwilling to adhere to study visit/procedure schedule and protocol requirements Can understand and voluntarily sign an informed consent form prior to any study-related assessments or procedures, and are able to adhere to the study visit schedule and other protocol requirements Ability to adhere with the study visit schedule and other protocol procedures Ability to voluntarily sign consent for and adhere to the entire study visit schedule and all protocol requirements Be willing and able to comply with the protocol-required visit schedule and visit requirements and provide written informed consent Able to adhere to study visit schedule and other protocol requirements. Able to adhere to study visit schedule and other protocol requirements Ability to understand and voluntarily sign informed consent prior to undergoing any study-related assessments or procedures, as well as adhere to the study visit schedule and other protocol requirements Ability to adhere to the study visit schedule and other protocol requirements Be able and willing to adhere to the study visit schedule and other protocol requirements Subject is willing and able to adhere to the study visit schedule and other protocol requirements. Subject is able to adhere to the study visit schedule and other protocol requirements. The patient is able to adhere to the study visit schedule and other protocol requirements, including follow-up for survival assessment. Inclusion Criteria: The patient is able to adhere to the study visit schedule and other protocol requirements, including follow-up for survival assessment. Subject is willing and able to adhere to the study visit schedule and other protocol requirements Willing and able to adhere to the study visit schedule and other protocol requirements. MDS Cohort: Able to adhere to the study visit schedule and other protocol requirements. Willing and able to adhere to the study visit schedule and other protocol requirements. Able to adhere to the study visit schedule and other protocol requirements. Ability to adhere to the study visit schedule and all protocol requirements; Able to adhere to the study visit schedule and other protocol requirements Understand and voluntarily sign an informed consent prior to any study-related assessments or procedures are conducted and are able adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements The patient is able to adhere to the study visit schedule and other protocol requirements, including follow-up for survival assessment. Patient is able and willing to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Patient must be willing to give written informed consent and must be able to adhere to dosing and visit schedules, and meet all study requirements. Patient must be able to adhere to the study visit schedule and other protocol requirements Participant is willing to adhere to the study visit schedule and other protocol requirements. Must be able to adhere to the study visit schedule and other protocol requirements Subject must be able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Is willing and able to adhere to the study visit schedule and other protocol requirements. Ability to provide informed written consent and be able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Ability to voluntarily sign consent for and adhere to the entire study visit schedule and all protocol requirements Patient is willing and able to adhere to the study visit schedule and other protocol requirements Ability to adhere to the study visit schedule and other protocol requirements Subjects must agree to adhere to all study requirements, including birth control measures and pregnancy testing, visit schedule, outpatient treatment, required concomitant medications, and laboratory monitoring Must be able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Able to adhere to study schedule and other protocol requirements Patients must be willing and able to sign the informed consent form, and to follow the study visit schedule and other protocol requirements. Was willing and able to adhere to the study visit schedule and other protocol requirements. Able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements. Able to adhere to the study visit schedule and other protocol requirements Subjects must be willing to adhere to the study visit schedule and other protocol requirements Patient must be able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Must be able to adhere to the study visit schedule and other protocol requirements. Must be able to adhere to the study visit schedule and other protocol requirements. Subject is able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements. Ability to adhere to the study visit schedule and other protocol requirements Inability to co-operate with the study visit schedule and other requirements of the protocol Able to adhere to the study visit schedule and other protocol requirements. Able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Ability to understand and voluntarily sign informed consent prior to undergoing any study-related assessments or procedures, as well as adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements. Disease Specific Able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements The patient is able to adhere to the study visit schedule and other protocol requirements, including follow-up for survival assessment. Able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Able to adhere to study visit schedule and other protocol requirements Able to adhere to the study visit schedule and requirements of the protocol Able to adhere to the study visit schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Subjects must be willing to adhere to the study visit schedule and other protocol requirements Able to adhere to study schedule and other protocol requirements Able to adhere to the study visit schedule and other protocol requirements Willing to give written informed consent, adhere to the visit schedules and meet study requirements Be able to adhere to the study visit schedule and other protocol requirements. Subject is willing and able to adhere to the study visit schedule and other protocol requirements. Willing and able to provide informed consent and adhere to the study visit schedule and plan as specified in this protocol Willing and able to give informed consent and adhere to visit/protocol schedules Able to adhere to study visit schedule and other protocol requirements including follow-up for survival assessment Willing and able to adhere to the study visit schedule and other protocol requirements