Hematological and biochemical indices within acceptable ranges at Screening. Adequate hematological and biological function, confirmed by the following laboratory values within 96 hours prior to enrollment: Bone Marrow Function Acceptable hematological function: Patients with confirmed advanced hematological malignancies Adequate hematological and organ function as confirmed by laboratory values Subjects with known >= grade 3 hematological toxicity with the last chemotherapy regimen Presence of an active hematological malignancy. Hematological function: Acceptable liver function, serum creatinine and hematological status Hematological values: Adequate hematological function, defined as: Immunocompromised patients with any hematological malignancies. Adequate hematological function Within 10 days of treatment initiation: Hematological\r\n* It is anticipated that refractory AML patients will have low hematological counts including platelet count, hemoglobin, and absolute neutrophil count. Thus, hematologic parameters will not be used for enrollment and initiation of treatment Subject has a history of coagulopathies or hematological disorders Presence of an active hematological malignancy: Hematological function: Participants with prior documented antecedent hematological disorder (AHD) Patients with acute hematological malignancies Patients diagnosed with hematological malignancies. Acceptable hematological status Acceptable hematological status Adequate hematological and biological function, confirmed by defined laboratory\n values Adequate hematological and organ function, confirmed by lab values Adequate hematological and organ function as confirmed by laboratory values Hematological malignancies Hematological function, as follows, without transfusion support: Hematological: Abnormal hematological function which is not due to bone marrow failure related to the CLL Adequate hematological parameters, i.e: Acceptable hematological status (without hematologic support Adequate hematological and biological function Adequate hematological function defined as: Antecedent hematological disorder (AHD) Hematological malignancy associated with a poor prognosis with medical therapy alone. Diagnoses to be included: Hematological Adequate hematological and biological function, confirmed by defined laboratory values Confirmed solid or hematological TP53 null type cancer. Adequate hematological function, defined as: Adequate hematological function, defined as: Must have adequate hematological function Acceptable hematological status, liver and renal function as defined in the protocol Acceptable hematological status: Hematological and biochemical indices within acceptable ranges shown at screening. Adequate hematological and biological function; LVEF ?50% Acceptable hematological status (without hematologic support Adequate hematological function (as defined in the study protocol) Adequate hematological and biological function Hematological function, as follows: Adequate hematological function With a hematological malignancy Diagnosed with any solid or hematological cancer Stage 3 or 4 breast cancer or any other concurrent malignancy including hematological malignancies (i.e. leukemia or lymphoma) Hematological: Total absolute phagocyte count ?1000/?L Patient is diagnosed with hematological malignancies including PTCL and CTCL and are eligible for treatment with a dose of 30 mg/m^2 Adequate hematological and biological function, confirmed by defined laboratory values