Serum creatinine below the upper limit of the institutional normal range (ULN) or creatinine clearance ? 60 mL/min/1.73 m2 for patients with serum creatinine levels above institutional ULN. Creatinine < 1.5 x institutional upper limit of normal or creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal Creatinine =< institutional upper limit or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal Creatinine clearance >= 50 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal Creatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above 1.5 x upper limit of normal Creatinine =< 1.5 x IULN or >= 60 ml/min/1.73 m^2 for subjects with creatinine levels above institutional normal Creatinine =< institutional upper limit of normal OR creatinine clearance >= 60 ml/min/1.73m^2 for patients with creatinine levels above institutional normal INCLUSION CRITERIA FOR SECOND-LINE THERAPY: Serum creatinine =< 1.5 X upper normal limit of institution's normal range OR creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal INCLUSION CRITERIA FOR THIRD-LINE THERAPY: Serum creatinine =< 1.5 X upper normal limit of institution's normal range OR creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal Creatinine < 1.5 mg/dL OR creatinine clearance ? 60 mL/min/1.73 m^2 for patients with creatinine levels > institutional normal within 14 days of registration Creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal Creatinine =< 1.5 x the upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 x the upper limit of normal Creatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal Creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Serum creatinine < 2 mg/dL OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (unless elevated creatinine or creatinine clearance felt by investigator to be acute and reversible) Creatinine =< 1.5 x institutional ULN OR creatinine clearance >= 60 mL/min by Cockcroft-Gault equation for participants with creatinine levels above institutional normal. Serum creatinine =< 1.5 x institutional ULN, OR creatinine clearance >= 60 mL/min/1.73 m^2 for participants with serum creatinine levels above 1.5 x institutional ULN Creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal Creatinine ? 1.5 x institutional ULN OR creatinine clearance ? 60 mL/min by Crockoft-Gault for participants with creatinine levels above institutional normal Creatinine within upper normal institutional limit OR creatinine clearance >= 50 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal Creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional ULN Creatinine =< 1.5 x within normal institutional ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional ULN Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Serum creatinine =< 1.5 x institutional ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with serum creatinine levels > 1.5 x higher than institutional normal Creatinine clearance >= 50 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal Within 2 weeks prior to initiation of study treatment: Creatinine =< upper limit of institutional normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< 1.5 x ULN or a creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal, determined within 14 days of registration Creatinine =< institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal COHORT I: Creatinine < 2 x upper limit of normal (ULN) or creatinine clearance >= 45 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal Creatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above 1.5 x institutional normal Creatinine < 2 x institution upper limit of normal OR creatinine clearance > 45 mL/min/1.73 m^2, for patients with creatinine levels above institutional normal Creatinine =< 1.5 X institutional upper limit of normal OR measured creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Serum creatinine < 2 x institutional upper limit of normal OR creatinine clearance >= 50 mL/min/for patients with creatinine levels above institutional normal Creatinine =< 1.5 x institutional ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 mg/dL Creatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine ? 1.5 x upper limit of normal (ULN) OR creatinine clearance ? 50 mL/min/1.73 m^2 (using Cockroft Gault Formula) for patients with creatinine levels above institutional normal Creatinine clearance >= 60 Ml/min/1.73 m^2 for patients with creatinine levels above institutional normal. Creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal. Creatinine ? 1.5 x IULN OR creatinine clearance ? 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< 1.5 x IULN or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< 1.5 x upper limit of normal (ULN) OR creatinine clearance > 50 mL/min/1.73 m2 for patients with creatinine levels =< 1.5 x upper limit above institutional normal Creatinine < institutional upper limit of normal (ULN) OR creatinine clearance >= 50 mL/min for patients with creatinine levels greater than ULN Serum creatinine =< 1.5 x institutional upper limit of normal (IULN) and creatinine clearance >= 75 mL/min Serum creatinine =< 1.5 x institutional ULN, OR creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with serum creatinine levels > 1.5 x higher than institutional normal Creatinine =< institutional upper limit of normal OR creatinine clearance >= 60 ml/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine clearance >= 40 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< upper limit of normal (ULN) OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above normal within 14 days of treatment initiation Creatinine clearance >= 45 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal. Obtained with 21 days of registration: creatinine =< 2 x institutional upper limit of normal OR creatinine clearance > 60 mL/min for patients with creatinine levels greater than institutional upper limit of normal Creatinine < 1.5 X institution upper limit of normal OR creatinine clearance >= 45 mL/min/1.73 m^2, for patients with creatinine levels above institutional normal Creatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels >= 1.5 x upper limit of normal (after the HDT/ASCT) Creatinine < 1.5 X institution upper limit of normal OR creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< 2.0 OR creatinine clearance > 30 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (creatinine clearance should be calculated per institutional standard) Serum creatinine below institutional upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with serum creatinine levels above institutional ULN Creatinine =< 1.5 ULN OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal OR creatinine clearance >= 60 mL/min for patients with creatinine levels above 1.5 X institutional upper limit of normal Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal, assessed within 14 days prior to registration Serum creatinine =< 1.5 x upper normal limit of institution's normal range or creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal Creatinine =< IULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine clearance > 60 mL/min for patients with creatinine levels above institutional normal Creatinine < 1.5 x institution upper limit of normal OR creatinine clearance >= 45 mL/min/1.73 m^2, for patients with creatinine levels above institutional normal Creatinine < 1.5 mg/dL OR creatinine clearance >= 50 mL/min for patients with creatinine levels above institutional normal Creatinine =< institutional upper limit of normal OR creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< IULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< IULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine clearance: > 60 ml/min for patients with creatinine levels above institutional normal Creatinine clearance >= 60 Ml/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< IULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal; creatinine clearance should be calculated using the actual weight from day 1 of the cycle Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine clearance >= 40 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine clearance < 40 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< 1.5 x ULN OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (Cockcroft formula) Creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine below institutional ULN or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal Creatinine =< the institutional upper limit of normal (ULN) OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Serum creatinine ? 1.5 × ULN OR creatinine clearance ? 50mL/min/1.73 m2 for subjects with creatinine levels above institutional normal Measured OR estimated creatinine clearance >= 40 mL/min/1.73 m^2 for patients with creatinine levels above normal Creatinine =< institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine above institutional upper limit of normal (IULN) obtained no more than 28 days prior to the start of neoadjuvant endocrine therapy Creatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min for patients with creatinine levels above institutional normal Creatinine < 1.5 x institutional upper limit of normal (ULN), OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels greater than 1.5 x ULN Serum creatinine =< 1.5 x upper limit of normal or creatinine clearance >= 60 ml/min for patients with creatinine levels above institutional normal Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< 1.5 x institutional upper limit of normal or creatinine clearance >= 50 mL/min/1.73 m^2 Creatinine =< institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (within 2 weeks prior to radiotherapy) Serum creatinine =< 1.5 × upper normal limit of institution's normal range OR creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal Creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal Within 4 weeks of preregistration: Creatinine =< institutional upper limit of normal (ULN) OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal ELIGIBILITY CRITERIA FOR REGISTRATION: creatinine =< institutional ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (within one week of registration if patient postop, otherwise within two weeks of registration) creatinine clearance greater than or equal to 60 mL/min/1.73 m2 for patients with creatinine levels above institutional normal Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< 1.5 x institutional ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 mg/dL Creatinine =< 1.5 x institutional ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 mg/dL Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< 1.5 x IULN OR creatinine clearance >= 40 mL/min by Cockcroft-Gault for patients with creatinine levels above institutional normal Creatinine =< IULN OR creatinine clearance >= 60 mL/min/1.73 m2 for patients with creatinine levels above institutional normal Serum creatinine =< 1.5 X upper normal limit of institution's normal range OR creatinine clearance >= 40 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal; creatinine clearance should be determined by the Cockcroft-Gault formula or by 24-hour urine collection for determination of creatinine clearance Creatinine level within normal institutional limit, or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine level above institutional normal Creatinine < 1.5 x institutional upper limit of normal (ULN) OR creatinine clearance (CrCl) >= 50 mL/min/1.73 m^2 for subjects with creatinine levels greater than 1.5 x ULN Creatinine clearance >= 60 ml/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine levels =< upper limit of institutional normal; or creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal Creatinine =< the institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal Creatinine =< 1.5 x ULN OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal TUMOR BIOPSY SEQUENCING: Creatinine < 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min for patients with creatinine levels >= 1.5 x institutional upper limit of normal TREATMENT: Creatinine < 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min for patients with creatinine levels >= 1.5 x institutional upper limit of normal Creatinine =< 1.5 x ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 45 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal Creatinine < 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< institutional upper limit of normal OR creatinine clearance >= 60 ml/min/1.73 m^2 for patients with creatinine levels above institutional normal Serum creatinine =< 1.5 × upper normal limit of institution's normal range OR creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< 1.5 mg/dL or creatinine clearance (Cockcroft-Gault) >= 60 mL/min for patients with creatinine levels above institutional upper limit of normal (ULN) PHASE II: Creatinine =< 1.5 mg/dL or creatinine clearance (Cockcroft-Gault) >= 60 mL/min for patients with creatinine levels above institutional upper limit of normal (ULN) Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above 1.5 X institutional upper limit of normal Creatinine < 1.5 x institutional upper limit of normal OR creatinine clearance > 60 ml/min OR > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< 1.5 x IULN OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Serum creatinine =< 1.5 x IULN OR calculated creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Serum creatinine =< 1.5 x institutional ULN OR creatinine clearance >= 45 mL/min/ 1.73 m^2 for participants with creatinine levels above institutional ULN Creatinine =< 1.5 × institutional upper limit of normal OR creatinine clearance >= 40 mL/min/1.73 m^2 for patients with creatinine levels above 1.5 x institutional limit of normal Creatinine ? 1.5 × ULN or, for patients with creatinine levels above institutional upper limit of normal, creatinine clearance must be > 60 mL/min/1.73 m^2. Creatinine clearance >60 mL/min/1.73 m2 for subjects with creatinine levels above institutional normal Creatinine clearance >= 60 Ml/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 X institutional upper limit of normal (ULN) Creatinine =< IULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine ? 1.5 × ULN or, for patients with creatinine levels above institutional upper limit of normal, creatinine clearance must be > 60 mL/min/1.73 m^2. Creatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 40 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine less than institutional ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< IULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< 1.5 x University of Iowa Hospitals and Clinics (UIHC) upper limit of normal or creatinine clearance of at least 60 ml/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine clearance > 60 mL/min for patients with creatinine levels above institutional normal Serum creatinine =< 1.5 x institutional upper limits of normal or for patients with creatinine levels above 1.5 x institutional normal: creatinine clearance >= 50 mL/min/1.73 m^2 by 24 hour urine collection or estimated creatinine clearance of >= 50 mL/min; for creatinine clearance estimation, the Cockcroft and Gault equation should be used Creatinine =< 1.5 mg/dL, or creatinine clearance >= 30 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal Creatinine clearance > 45 mL/min/1.73 m^2, for patients with creatinine levels above institutional normal Creatinine =< IULN OR creatinine clearance >= 40 mL/min for patients with creatinine levels above institutional normal Serum creatinine < 2.0 mg/dL or creatinine clearance (Cockcroft) >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Serum creatinine =< 1.5 x IULN OR creatinine clearance > 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine less than or equal to the institutional upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal Creatinine below institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Serum creatinine =< institutional ULN or creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal Creatinine less than or equal to 1.5 times the ULN OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine clearance >= 30 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal Within 14 days of registration: Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< institutional ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal PHASE I: Creatinine between 0-1.3 mg/dL or creatinine clearance > 60 mL/min/1.73 m^2 for subjects with creatinine levels about institutional normal PHASE II: Creatinine between 0-1.3 mg/dL or creatinine clearance > 60 mL/min/1.73 m^2 for subjects with creatinine levels about institutional normal Creatinine =< institutional upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal Creatinine < 1.5 X institutional upper limit of normal OR creatinine clearance >= 30 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine up to 1.5 X ULN or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels about institutional normal Creatinine < 1.5 X institutional upper limit of normal OR calculated creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< institutional ULN or creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal or >= 50 mL/min 24-hour creatinine clearance Creatinine < 1.5 X institutional upper limit of normal OR creatinine clearance >= 60 mL/min for patients with creatinine levels above 1.5 X institutional upper limit of normal Creatinine within 1.5 x upper limit of normal, OR creatinine clearance > 60 mL/min for patients with creatinine levels above institutional normal PART B: Creatinine =< 1.5 X ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine < 1.5 x institution upper limit of normal OR creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine < or equal to 1.5 x ULN or creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine ? 1.5 × ULN or creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal. Serum creatinine =< the institutional upper limit of normal or creatinine clearance >= 40 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal Serum creatinine ? 1.5 x ULN or creatinine clearance > 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal Creatinine < 1.5 x institutional upper limit of normal or creatinine clearance >= 50 mL/min/1.73 m^2 Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< 1.5 x institutional ULN or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional ULN Creatinine =< 1.5 x upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 x upper limit of normal creatinine clearance > 60 mL/min for patients with creatinine levels above institutional normal Serum creatinine levels =< 1.5 x upper limit of normal (ULN) OR creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal Creatinine less than the institutional upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal Serum creatinine =< 1.5 × upper normal limit of institution's normal range OR creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal Within 14 days after subjects signed the treatment consent: Serum creatinine =< 1.5 mg/dl OR creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal Creatinine ? 2.0 mg/dl Or Creatinine clearance ? 60 mL/min/1.73 m2 for patients with creatinine levels above institutional normal Creatinine less than institutional upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above the institutional normal Creatinine < 1.5 x upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels >= 1.5 x upper limit of normal Creatinine =< 1.5 mg/dL or creatinine clearance >= 50 mL/min for subjects with creatinine levels about institutional normal EXPANSION COHORT ONLY: Creatinine =< 1.5 mg/dL or creatinine clearance >= 50 mL/min for subjects with creatinine levels about institutional normal Creatinine =< institutional ULN or creatinine clearance >= 30 mL/min/1.73 m^2 for subjects with creatinine levels above institutional ULN Creatinine =< the institutional upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal Creatinine clearance >= 60 mL/min for patients with creatinine levels above 1.5 x institutional upper limit of normal Creatinine < 1.5 x upper limit of normal OR measured creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 x upper limit of normal Serum creatinine =< 1.5 x upper normal limit of institution's normal range OR creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal Creatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance > 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal creatinine clearance* >45 mL/min/1.73 m2 for patients with creatinine levels above institutional normal Creatinine =< 1.2 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine above institutional normal Creatinine =< 1.5 x institutional ULN or creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal, obtained through calculated or measured creatinine clearance Creatinine within normal institutional limit for the reference lab OR creatinine clearance >= 60 mL/min/1.73 m^2 as calculated by Cockcroft-Gault formula for participants with creatinine levels above institutional normal Creatinine within 1.5 x upper limit of normal OR creatinine clearance > 60 mL/min for patients with creatinine levels above institutional normal Creatinine =< institutional upper limit of normal OR creatinine clearance >= 60 ml/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Serum creatinine =< 1.5 X upper normal limit of institution's normal range OR creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal Creatinine not to be above IULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine < institutional upper limit of normal (ULN) OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels greater than ULN Creatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Serum creatinine =< 1.5 x upper limit of normal or creatinine clearance >= 60ml/min for patients with creatinine levels above institutional normal Creatinine < 1.5 X institution upper limit of normal OR creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine less than the institutional upper limit of normal OR creatinine clearance >= 50 mL/min/1.73 m^2 Renal: serum creatinine WNL or calculated creatinine clearance ? 50 mL/min/1.73m2 for patients with creatinine levels above institutional normal Creatinine < 1.5 x institutional upper limit or normal OR creatinine clearance >= 60 mL/min for patients with creatinine levels above 1.5 x institutional upper limit of normal Creatinine =< institution upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Serum creatinine < 1.5 x ULN or creatinine clearance > 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< institutional upper limit of normal OR creatinine clearance >= 60 ml/min/1.73 m^2 for patients with creatinine levels above institutional normal Serum creatinine =< institutional upper limit of normal or creatinine clearance (either estimated or calculated) >= 60 mL/min/1.73 m for patients with creatinine levels above institutional normal Creatinine below 1.5 X upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for subjects with creatinine levels about institutional normal Creatinine =< 2 X institutional ULN OR creatinine clearance >= 30 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Serum creatinine =< 1.5 x ULN OR creatinine clearance >= 60 ml/min for patients with creatinine levels above institutional normal Creatinine =< institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine < 1.5 X institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine < 1.5 X institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within 1.5 x institutional upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine level above institutional normal Creatinine =< 1.5 X institutional upper limit of normal or creatinine clearance less than 60 ml/min Creatinine < 1.5 x upper limit of normal (ULN) or creatinine clearance >= 50 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal Creatinine =< IULN OR creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine clearance ? 15 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal Creatinine =< 2.0 or creatinine clearance > 30 mL/min/1.73 m^2 for subjects with creatinine levels above institutional normal Creatinine =< institutional upper limit of normal OR creatinine clearance >= 30 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal Creatinine clearance >= 70 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal Creatinine =< institutional upper limit of normal OR creatinine clearance >= 60 ml/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine clearance >= 60 mL/min for subject with creatinine levels > 1.5 x institutional upper limit of normal (ULN) Creatinine clearance >= 50 ml/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine =< 1.5 times institutional upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2 Creatinine £ 1.5 ´ ULN or creatinine clearance > 60 mL/min/1.73 m2 for patients with creatinine levels above institutional normal Creatinine below upper limit of normal OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine within 1.5 x upper limit of normal (ULN) OR creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal Creatinine ? 1.5 mg/dL or creatinine clearance > 60 mL/min/1.73 m2 for subjects with creatinine levels above institutional normal. Creatinine =< 1.5 X institutional upper limit of normal or creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal