Histologically confirmed diagnosis of adenocarcinoma of the rectum Histologically or cytologically confirmed prostate cancer Participants must have histologically or cytologically confirmed adenocarcinoma of the colon or rectum Participants must have histologically or cytologically confirmed adenocarcinoma of the rectum Histologically or cytologically confirmed adenocarcinoma of the prostate Histologically or cytologically confirmed adenocarcinoma of the prostate Histologically- or cytologically-confirmed diagnosis of adenocarcinoma or squamous cell carcinoma of the esophagus or Siewert type I adenocarcinoma of the EGJ Histologically confirmed adenocarcinoma of the breast Histologically or cytologically confirmed adenocarcinoma of the prostate previously treated with surgery and/or radiotherapy. Have a histologically or cytologically confirmed adenocarcinoma or poorly differentiated carcinoma of the prostate Histologically or cytologically confirmed PSCC Histologically or cytologically confirmed adenocarcinoma of the prostate without pure small cell carcinoma; patients without histologically confirmed adenocarcinoma may be eligible if both the treating physician and the study principal investigator (PI) agree that the patient’s history is unambiguously indicative of advanced adenocarcinoma Patients must have histologically or cytologically confirmed metastatic or unresectable adenocarcinoma of the colon or rectum Histologically or cytologically confirmed adenocarcinoma of the prostate and the availability archival prostate tumor sample is required Participants with histologically or cytologically confirmed diagnosis of adenocarcinoma of the GEJ or stomach will be enrolled in this study Histologically or cytologically confirmed adenocarcinoma of the colon or the rectum that is metastatic or unresectable. Histologically and cytologically documented diagnosis as gastroesophageal adenocarcinoma. Patients must have histologically or cytologically confirmed adenocarcinoma of the prostate Histologically or cytologically confirmed adenocarcinoma of prostate. Histologically or cytologically confirmed prostate carcinoma. Has histologically or cytologically documented adenocarcinoma NSCLC. Histologically or cytologically confirmed adenocarcinoma of the prostate. Has histologically or cytologically confirmed diagnosis of adenocarcinoma of the prostate; Subjects must have histologically or cytologically confirmed adenocarcinoma of the prostate Histologically or cytologically confirmed adenocarcinoma of the breast with unresectable or metastatic disease Histologically or cytologically confirmed adenocarcinoma of the prostate Histologically or cytologically confirmed adenocarcinoma of the prostate New diagnosis of histologically confirmed adenocarcinoma of the rectum Histologically or cytologically confirmed adenocarcinoma of the prostate (the availability archival prostate tumor sample is preferred not required) Histologically or cytologically confirmed adenocarcinoma of the prostate Histologically or cytologically confirmed Histologically or cytologically confirmed adenocarcinoma of the breast Histologically or cytologically confirmed adenocarcinoma of the prostate (excluding predominant small cell histology) Histologically or cytologically confirmed adenocarcinoma of the prostate Patients must have histologically or cytologically confirmed adenocarcinoma of the prostate Histologically confirmed metastatic adenocarcinoma of the lung Histologically or cytologically confirmed prostate adenocarcinoma Has histologically- or cytologically-confirmed adenocarcinoma of the prostate without small cell histology Histologically confirmed adenocarcinoma of the rectum Histologically or cytologically proven adenocarcinoma of the colon or rectum The subject has histologically or cytologically proven adenocarcinoma of the breast that is HER2+ The patient has histologically, or cytologically, confirmed adenocarcinoma of the prostate. Have a histologically or cytologically confirmed adenocarcinoma or poorly differentiated carcinoma of the prostate Histologically or cytologically confirmed diagnosis of biliary tract adenocarcinoma/cholangiocarcinoma Histologically or cytologically confirmed adenocarcinoma of the prostate without pure small cell carcinoma; patients without histologically confirmed adenocarcinoma may be eligible if both the treating physician and the study principal investigator (PI) agree that the patient’s history is unambiguously indicative of advanced adenocarcinoma Histologically or cytologically confirmed adenocarcinoma of the prostate Histologically or cytologically confirmed carcinoma of the prostate Histologically or cytologically confirmed adenocarcinoma of the prostate Histologically or cytologically confirmed adenocarcinoma of the prostate Participants must have histologically or cytologically confirmed adenocarcinoma of the prostate Diagnosis of histologically or cytologically confirmed metastatic adenocarcinoma of the colon or rectum. Histologically or cytologically confirmed adenocarcinoma of the prostate Histologically or cytologically confirmed adenocarcinoma of the prostate at either MSKCC or at the participating site I 01. Histologically- or cytologically-confirmed prostate adenocarcinoma. Histologically or cytologically confirmed HER2-negative adenocarcinoma of the breast Histologically or cytologically confirmed adenocarcinoma of the colon or rectum that is metastatic. Histologically or cytologically confirmed prostate cancer Histologically or cytologically confirmed adenocarcinoma of the prostate. Histologically or cytologically confirmed adenocarcinoma consistent clinically with androgen independent prostate cancer Histologically or cytologically proven adenocarcinoma of the breast Diagnosis of histologically or cytologically confirmed prostate adenocarcinoma. Histologically or cytologically confirmed metastatic adenocarcinoma of the colon or rectum Histologically or cytologically proven adenocarcinoma of the prostate Histologically or cytologically confirmed adenocarcinoma of the breast. Patient must have histologically or cytologically confirmed colorectal adenocarcinoma or small bowel adenocarcinoma Histologically or cytologically confirmed diagnosis of prostate adenocarcinoma, surgically castrated or continuous medical castration (for >=8 weeks prior to Screening) Histologically or cytologically confirmed adenocarcinoma of the prostate; The participant has histologically or cytologically confirmed, nonsquamous (adenocarcinoma/large cell or other) NSCLC. Histologically or cytologically confirmed adenocarcinoma of the prostate; Have a histologically or cytologically-confirmed diagnosis of adenocarcinoma of the GEJ or stomach Histologically or cytologically confirmed unresectable or metastatic esophagogastric adenocarcinoma Histological or cytologically confirmed prostate adenocarcinoma Has histologically or cytologically documented adenocarcinoma NSCLC