Patients must have a complete history and physical examination within 28 days prior to registration Patients must have a complete history and physical examination within 28 days prior to registration Patients must have a complete physical examination and medical history within 28 days prior to step 2 randomization Patients must have complete history and physical examination within 28 days prior to registration Patients must have a complete physical examination and medical history within 28 days prior to registration Patients must have complete history and physical examination within 28 days prior to registration History/physical examination (to include at a minimum digital rectal examination of the prostate and examination of the skeletal system and abdomen) within 90 days prior to registration Patients must have a complete history and physical examination within 28 days prior to registration History/physical examination within 28 days prior to step 2 registration History/physical examination within 90 days prior to Step 1 registration Patients must have complete history and physical examination within 28 days prior to registration History/physical examination, including neurologic examination within 60 days prior to step 2 registration History/physical examination within 21 days prior to study entry Patients must have complete history and physical examination within 28 days prior to registration History/physical examination with digital rectal examination of the prostate and baseline toxicity assessment within 90 days prior to randomization. Must have a pertinent history/physical examination within 90 days prior to registration Appropriate stage for study entry based on the following diagnostic workup:\r\n* History/physical examination within 28 days prior to registration\r\n* Radiographic imaging of the chest, abdomen and pelvis within 28 days prior to registration documenting disease consistent with FIGO stage III or IV disease\r\n* Further protocol-specific assessments Participants must have a complete history and physical examination within 45 days of study entry\r\n* Participants must have a digital rectal examination (confirming clinical stage T1c to T2c) of prostate within 180 days of study entry History/physical examination within 7 days prior to registration General history and physical examination within 8 weeks prior to registration Participants must have a complete history and physical examination within 60 days of study entry General history and physical examination by a radiation oncologist and medical oncologist within 4 weeks prior to enrollment. History/physical examination within 30 days prior to registration History/physical examination within 30 days prior to registration History/physical examination by the treating physician within 24 hours prior to registration History/physical examination with digital rectal examination of the prostate within 90 days prior to study enrollment History and physical with neurological examination, height, and weight within 14 days prior to registration Patients must have a complete history and physical examination within 30 days prior to registration No evidence of distant metastasis based on a history/physical examination (to include at least digital rectal examination of the prostate and assessment of the abdomen and skeletal system) Within 30 days of registration: patients must have vital signs, history/physical examination, laboratory studies (complete blood count panel [CBCP] with differential, chemistries including liver function tests, creatinine clearance [CrCl] assessment; pregnancy test if needed within 14 days of registration) Patient must have a history/physical examination with digital rectal examination of the prostate within 90 days prior to screening History/physical examination (to include at a minimum digital rectal examination of the prostate and examination of the skeletal system and abdomen) within 90 days prior to registration History/physical examination with digital rectal examination of the prostate within 90 days prior to registration History and physical with neurological examination, steroid documentation, height, and weight within 14 days of registration Completion of a comprehensive evaluation, including clinical history and physical examination, to eliminate other causes of their symptoms History/physical examination within 42 days prior to registration to document cervical tumor size and stage History/physical examination to include, at a minimum, digital rectal examination of the prostate and examination of the skeletal system and abdomen, and formal comorbidity assessment via the Charlson Comorbidity Index within 60 days prior to registration Appropriate stage for study entry based on the following diagnostic workup:\r\n* History/physical examination within 28 days prior to registration\r\n* Imaging of the chest, abdomen and pelvis within 30 days prior to registration Patients must have a complete history and physical examination within 30 days prior to registration History/physical examination within 28 days prior to registration Appropriate stage for study entry based on the following diagnostic workup:\r\n* History/physical examination within 28 days prior to registration\r\n* Imaging of target lesion(s) within 28 days prior to registration\r\n* Completion of pre-study protocol specific assessments as required History and physical examination including weight, performance status, and body surface area within 8 weeks prior to study registration Patients must have complete history and physical examination within 28 days prior to registration Complete history and physical examination noting in detail the exact size and location of any lesions that are detected on examination will be performed within 30 days prior to initiation of chemotherapy History/physical examination, including documentation of weight, within 2 weeks prior to registration History and physical examination within 6 weeks of registration Patients must have a complete history and physical examination within 28 days prior to registration Patients must have a complete physical examination and medical history within 28 days prior to registration Patients must have a complete history and physical examination within 28 days prior to registration Patients must have a complete physical examination and medical history within 28 days prior to registration Complete history and physical examination including weight and Zubrod status within 31 days of study entry (or within 31 days prior to day 1 of chemotherapy post-surgery for those patients having started chemotherapy prior to first step registration) Patients must have a complete physical examination and medical history within 28 days prior to registration Patients must have complete history and physical examination within 28 days prior to registration History/physical examination within 30 days prior to registration History/Physical examination by a Radiation Oncologist and Medical oncologist prior to entering the study. Patients must have history and physical examination within 28 days prior to registration Appropriate stage for study entry based on the following diagnostic workup:\r\n* History/physical examination within 42 +/- 5 days of planned surgical procedure (18-21 days from day 1);\r\n* Further protocol-specific assessments History/physical examination within 7 days prior to registration History/physical examination within 45 days prior to study registration Patients must have a complete physical examination and medical history within 28 days prior to Step 2 Randomization Appropriate stage for protocol entry, based upon the following minimum diagnostic workup within 60 days prior to registration:\r\n* History/physical examination including weight, performance data, body surface area History/physical examination (to include, at a minimum, digital rectal examination of the prostate and examination of the skeletal system and abdomen, and formal comorbidity assessment via the ACE-27 instrument) within 60 days prior to registration; Note: the ACE-27 is posted on the 0815 protocol information page on the NRG Oncology/Radiation Therapy Oncology Group (RTOG) web site History/physical examination Appropriate stage for study entry based on the following diagnostic workup:\r\n* History/physical examination within 28 days prior to registration Presence of any clinically significant findings at entry for medical history, laboratory values, or physical examination Patients must have a complete physical examination and medical history within 28 days prior to registration History/physical examination, including neurologic examination, within 14 days prior to registration History/physical examination within 28 days prior to registration Patients must have a complete physical examination and medical history within 28 days prior to registration Physical examination, and scans needed for tumor assessment must be performed within 90 days prior to registration History/physical examination within 60 days prior to registration to document cervical tumor size and stage History/physical examination with digital rectal examination of the prostate within 8 weeks prior to registration History/physical examination within 30 days prior to registration Measurable disease by radiographic or physical examination Patients must have a history and physical examination obtained within 28 days prior to registration Measurable tumor by physical or radiographic examination Unstable brain or leptomeningeal disease based on history and physical examination. History and physical examination, including neurologic examination, within 2 weeks prior to registration History and physical with neurological examination, steroid documentation, height, and weight within 14 days of registration History, physical and performance status of 2 or less within 180 days prior to registration Patients must have a complete physical examination and medical history within 28 days prior to registration Appropriate stage for study entry based on the following diagnostic workup:\r\n* History/physical examination within 60 days prior to registration\r\n* Magnetic resonance imaging (MRI) of the brain with contrast within 30 days prior to registration Patients must have complete physical examination and medical history obtained within 28 days prior to registration History/physical examination within 14 days prior to registration History/physical examination within 2 weeks prior to registration History and physical examination within 28 days prior to Step 2 registration Have complete history and physical examination documenting no clinical evidence of disease within 8 weeks of registration History/physical examination within 30 days prior to registration Pathologically proven diagnosis of cancer any stage, based upon the following minimum diagnostic workup:\r\n* History & physical examination, including documentation of Karnofsky performance status of 70-100% for at least 60 days prior to study entry Any confirmed or suspected immunosuppressive or immunodeficient condition, based on medical history and physical examination.