Other severe acute or chronic medical or psychiatric condition or laboratory abnormality Has a serious illness or medical condition(s) Any known clinically significant concomitant medical condition, laboratory abnormality, or psychiatric illness that, in the investigator’s opinion, would prevent the subject from participating in the study, pose an unacceptable risk to the patient in this study, or interfere with the interpretation of safety results Any other significant medical illness, abnormality, or condition Serious illness or medical condition. Subject has any significant medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from participating in the study. Any serious medical condition, laboratory abnormality, uncontrolled intercurrent illness, or psychiatric illness/social condition that would prevent study participation Any serious medical condition, laboratory abnormality, uncontrolled intercurrent illness, or psychiatric illness/social condition that would prevent study participation Any significant medical condition, laboratory abnormality, or psychiatric illness that would prevent the patient from participating in the study Patients with any concurrent uncontrolled clinically significant medical condition, including infection, laboratory abnormality, or psychiatric illness which could place the patient at unacceptable risk of study treatment. Patients who have prior or ongoing clinically significant illness, medical condition, surgical history, physical finding, or laboratory abnormality as determined by the investigator. Subject who, in the opinion of the Investigator, has any significant medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from participating in the study. A serious illness or medical condition Serious illness or medical condition that could affect the safety or tolerability of study treatments Subject has concurrent, uncontrolled medical condition, laboratory abnormality, or psychiatric illness, which could place him/her at unacceptable risk Has a serious illness or medical condition(s) that would affect safety or tolerability of the study treatments Other serious illness or medical condition(s) (see protocol) Unstable or severe uncontrolled medical condition (eg, unstable cardiac function, unstable pulmonary condition), or any important medical illness or abnormal laboratory finding that would, in the Investigator's judgment, increase the subject's risk while participating in this study Any other significant medical condition, including psychiatric illness or laboratory abnormality, that would preclude the patient participating in the trial or would confound the interpretation of the results of the trial Any serious medical condition or abnormality in clinical laboratory tests Any significant medical condition, laboratory abnormality, or psychiatric illness, that would prevent subjects from participating in the study, including the inability to swallow capsules The participant has a serious illness or medical condition including: Subject has any significant medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from participating in the study. Any other significant medical illness, abnormality, or condition. Subject has any significant medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from participating in the study. Any significant medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from participating in the study Any significant medical condition, laboratory abnormality, or psychiatric illness Any significant medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from participating in the study. Any significant medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from participating in the study. Any significant medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from participating in the study. Any significant medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from participating in the study. Serious concurrent illness, altered medical status or any uncontrolled medical condition Other serious concurrent illness or medical condition. Unstable or severe uncontrolled medical condition (eg, unstable cardiac function, unstable pulmonary condition), or any important medical illness or abnormal laboratory finding that would, in the investigator's judgment, increase the subject's risk while participating in this study The patient has any significant medical condition, laboratory abnormality, or psychiatric illness that would prevent the patient from participating in the study. Any important medical illness or abnormal laboratory finding that would increase the risk of participating in this study Certain serious illness or medical condition(s) For Part D, have a serious illness or medical condition(s), including but not limited to the following: Any concurrent, uncontrolled medical condition, laboratory abnormality, or psychiatric illness which could place him/her at unacceptable risk Any serious medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from participating in the study. Known serious illness or medical condition Other serious concurrent illness or medical condition. Any significant medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from participating in the study. Prior or ongoing clinically significant illness, medical condition, surgical history, physical finding, electrocardiogram (ECG) finding, or laboratory abnormality Any serious illness or medical condition that could affect participation on trial Any significant medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from participating in the study. Any important medical illness or abnormal laboratory finding that would increase the risk of participating in this study Serious cardiac illness or medical condition including but not confined to: Clinically significant illness, medical condition, surgical history, physical finding, or laboratory abnormality that could affect the safety of the patient; alter the absorption of the study drugs; or impair the assessment of study results. Other serious concurrent illness or medical condition. Any serious medical condition, laboratory abnormality, or psychiatric illness that, in the view of the treating physician, would place the participant at an unacceptable risk if he or she were to participate in the study or would prevent that person from giving informed consent. Any serious medical condition, lab abnormality or psychiatric illness Any important medical illness or abnormal laboratory finding that would, in the investigator's judgment, significantly increase the subject's risk of participating in this study Any serious medical condition, laboratory abnormality, or psychiatric illness that, in the view of the treating physician, would place the participant at an unacceptable risk if he or she were to participate in the study or would prevent that person from giving informed consent Any significant medical condition, laboratory abnormality, or psychiatric illness that, as determined by the treating Investigator, would prevent the subject from participating in the study or providing written informed consent Any significant medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from participating in the study Subject has any significant medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from participating in the study based on investigator´s judgment. Has a serious illness or medical condition(s)