Active infection requiring systemic therapy Patients must not have an active infection requiring systemic therapy at time of registration Patients must not have an active infection requiring systemic therapy Patients must not have an active infection requiring systemic therapy Active infection (any infection requiring systemic treatment) Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy. Active infection requiring systemic therapy Has an active infection requiring systemic therapy. Has a known active infection requiring systemic therapy Has an active infection requiring systemic therapy Active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Patient has an active infection requiring systemic therapy SAFETY RUN-IN: Active infection requiring systemic therapy Has an active infection requiring therapy. Has an active infection requiring systemic therapy Active infection requiring systemic therapy Active infection requiring systemic therapy Has an active infection requiring systemic therapy. Active infection requiring systemic therapy. Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy. Active infection requiring systemic therapy. Has an active infection requiring systemic therapy An active infection requiring systemic therapy Has an active infection requiring systemic therapy Active infection (any infection requiring systemic treatment) Active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring therapy. Active infection requiring systemic therapy Active infection requiring systemic therapy Has an active infection requiring systemic treatment Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring therapy. Patient has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Active infection requiring systemic therapy; NOTE: when the infection is controlled, patients are permitted for this study Has an active infection requiring systemic therapy. Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Active infection requiring systemic therapy at the time of study treatment initiation Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Active infection requiring systemic therapy Active infection requiring systemic therapy. Participants must not have an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection at the time of cycle 1 day 1 requiring systemic therapy Has an active infection requiring systemic therapy. Has an active infection requiring systemic therapy. Active infection requiring systemic therapy Active infection requiring systemic therapy Active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy. Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy. Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Active infection requiring systemic therapy Has an active infection requiring systemic therapy. Has an active infection requiring systemic therapy Active infection requiring systemic therapy active infection requiring systemic therapy; Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy. Patient has active infection requiring system therapy Active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Active infection requiring systemic therapy Active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Other active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring intravenous systemic therapy Has an active infection requiring systemic therapy Active infection requiring systemic therapy. Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has active infection requiring systemic therapy Has an active infection requiring systemic therapy Any active infection requiring systemic treatment Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Active infection requiring systemic therapy Has an active infection requiring systemic therapy Patients active infection requiring intravenous systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Active infection requiring systemic therapy. Patient has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Active infection, requiring systemic therapy Has an active infection requiring systemic therapy Active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring intravenous systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy. Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Active infection requiring systemic therapy Has an active infection requiring intravenous systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring intravenous systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Current active infection requiring systemic therapy Has an active infection requiring systemic therapy Have an active infection requiring systemic therapy. Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring intravenous systemic therapy or hospital admission Has an active infection requiring systemic therapy Has an active infection requiring intravenous systemic therapy or hospital admission Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy. Active infection requiring systemic therapy Has an active infection requiring systemic therapy Active infection requiring therapy Active infection requiring systemic therapy. Has an active infection requiring systemic therapy Active infection requiring systemic therapy Has an active infection requiring systemic treatment Any other active malignancy requiring systemic therapy Active infection requiring systemic therapy Acute active infection requiring systemic therapy within 2 weeks prior to enrollment Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy or hospital admission Has an active serious bacterial infection requiring systemic therapy Subject has an active infection requiring systemic therapy, including active tuberculosis Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring intravenous systemic therapy Has an active infection requiring systemic therapy Active infection requiring therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Active infection requiring therapy Patient has an active infection requiring systemic therapy Active carcinoma requiring systemic chemotherapy or radiation therapy Active infection requiring systemic therapy. Active infection requiring systemic antibiotic therapy. Patients requiring systemic antibiotics for infection must have completed therapy before Screening is initiated An active infection requiring systemic IV therapy. Has an active infection requiring systemic therapy Active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy. Has an active infection requiring systemic therapy Active infection requiring systemic therapy; Active infection requiring systemic therapy. Active infection requiring systemic therapy Active infection requiring systemic therapy. Has an active infection requiring systemic therapy Active infection requiring systemic therapy. Has an active infection requiring systemic therapy REGISTRATION TO TREATMENT (STEP 1): Patient must not have an active infection requiring systemic therapy REGISTRATION TO TREATMENT (STEP 2): Patient must not have an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy. Active infection requiring systemic therapy Patient has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active viral infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Active infection requiring systemic therapy Has an active infection requiring systemic therapy Active or chronic infection requiring systemic therapy Has an active infection requiring systemic therapy Active infection requiring systemic therapy Participants with an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Active infection requiring systemic therapy Has an active infection requiring systemic therapy Active infection requiring systemic therapy Has an active infection requiring systemic treatment Has an active infection requiring systemic therapy. Active infection requiring intravenous systemic therapy. Active infection requiring systemic therapy Has an active infection requiring systemic therapy. Has an active infection requiring systemic therapy Patients must not have an active infection requiring systemic therapy Active infection requiring systemic therapy. Has an active infection requiring systemic therapy. Active infection requiring systemic therapy. Has an active infection requiring therapy. Has an active infection requiring systemic therapy. Active infection requiring systemic therapy Presence of active infection requiring systemic therapy Subject has active infection requiring systemic therapy Active infection requiring systemic therapy at enrollment Has an active infection requiring systemic treatment Active systemic infection requiring treatment. Infection controlled by oral therapy will not be exclusionary. Has an active infection requiring systemic therapy or uncontrolled infection. Active systemic infection requiring treatment. Infection controlled by oral therapy will not be exclusionary. Active infection requiring therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy No active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Active infection requiring IV systemic therapy Active infection requiring systemic therapy within 14 days Active infection requiring systemic therapy Active infection requiring systemic therapy. Active infection requiring systemic therapy Has an active infection requiring systemic therapy Active infection requiring systemic antibiotic therapy. Patients requiring systemic antibiotics for infection must have completed therapy before Screening Has an active infection requiring systemic therapy Active infection requiring systemic therapy Has an active infection requiring systemic therapy Ongoing or active infection requiring systemic treatment Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Active infection requiring systemic therapy Participant has an active infection requiring therapy. Has an active infection requiring systemic therapy Active infection requiring systemic therapy. Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy (? grade 2) for more than 3 days within 1 week of enrollment. Active infection requiring systemic therapy Active infection requiring therapy Has an active infection requiring systemic therapy Active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Active infection requiring systemic therapy Active infection requiring systemic therapy Active infection requiring systemic therapy Active infection requiring systemic therapy Active infection requiring systemic therapy Has any active infection requiring systemic therapy Active infection requiring systemic therapy. Presence of an active systemic infection requiring treatment. Has an active infection requiring systemic therapy Active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy. Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Active infection requiring systemic therapy; Active infection (any infection requiring systemic treatment) Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring therapy Evidence of active infection requiring systemic therapy Have an active infection requiring systemic therapy Has an active infection requiring systemic therapy Active infection requiring systemic therapy. Has an active infection requiring systemic therapy. Has an active infection requiring systemic therapy. Has an active infection requiring systemic therapy evidence of active infection requiring systemic therapy. Active infection requiring therapy Patient has an active systemic infection requiring treatment. Active, serious infection requiring systemic therapy Patients with active infection requiring systemic treatment Has an active infection requiring systemic therapy Evidence of active infection requiring systemic therapy Has an active infection requiring intravenous systemic therapy Has active infection requiring systemic therapy Active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy. Active infection requiring systemic therapy Current active infection requiring systemic treatment. Active infection requiring systemic therapy Has an active infection requiring systemic therapy Active infection requiring systemic therapy Has an active infection requiring systemic treatment Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy. Has an active infection requiring systemic therapy Has an active infection requiring intravenous systemic therapy. Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy Has an active infection requiring systemic therapy